Laurie, Steven (Date of defense: 2013-07-25)
This thesis comprises comparative genomics analyses primarily focussing on the evolution of mammalian proteins. We concentrate on three species of direct relevance as model organisms, for which high ...
Toll i Riera, Macarena (Date of defense: 2012-03-28)
Actualment, degut a la disponibilitat d’un gran nombre de genomes seqüenciats, el camp de la genòmica comparativa està experimentant grans avenços. Ara són possibles una àmplia gama d’estudis que fins ...
Ruiz Orera, Jorge (Date of defense: 2017-01-19)
Aquesta tesi investiga els mecanismes de formació i evolució de gens de novo utilitzant seqüenciació massiva de transcrits complerts i de fragments protegits per ribosomes. Hem identificat milers de ...
Bellora Pereyra, Nicolás (Date of defense: 2010-02-26)
Regulation of gene transcription is a complex process involving many different proteins, some of which bind in a sequence-specific manner to DNA motifs in the gene promoter. The need to maintain specific ...
Villanueva Cañas, José Luis (Date of defense: 2015-11-20)
Although the genome sequencing revolution is still in its infancy, we must acknowledge it as the major driver of biology since the beginning of the 21st century. The availability of a large collection ...
Blevins, William Robert (Date of defense: 2020-01-17)
All living organisms respond to environmental stimuli by modulating the activity of different genes. This response can occur across many locations throughout the cell such as at the level of transcription, ...
Shikhagaie, Medya (Date of defense: 2011-11-07)
In the present study, we have approached the molecular characterization of the HCMV specific UL1. To this end a HCMV (AD169-derived HB5 background) recombinant with an HA-epitope tagged UL1 and a mutant ...
Mularoni, Loris (Date of defense: 2009-07-28)
Tandem amino acid repeats, also known as homopolimeric tract or homopeptides, are very common features of eukaryotic genomes and are present in nearly one-fifth of human encoded proteins. These structures ...
Radó i Trilla, Núria (Date of defense: 2013-05-03)
In this thesis we aimed to study evolutionary implications of low-complexity regions, protein sequences of very simple amino acid composition. Its uncontrolled expansion causes several human diseases, ...
Ledda, Alice (Date of defense: 2011-05-06)
Els microsat el lits s on seq u encies d'ADN formades per repeticions en t andem de motius curts. Les curtes seq u encies repetides en t andem s on ubiq ues en els genomes dels eucariotes, tant en les ...