Corrionero Saiz, Ana (Date of defense: 2010-12-16)
Alternative splicing provides the cell the ability to generate, from a single gene, multiple protein isoforms, sometimes with different or even antagonistic functions. This process is tightly regulated ...
Hoffmann, Tobias (Date of defense: 2021-04-08)
The splicing regulatory protein RBM10 is frequently mutated in bladder carcinomas. Analysis of RNA sequencing data of 476 bladder tumours (UROMOL) identified 469 alternative splicing (AS) events ...
Vivori, Claudia (Date of defense: 2019-02-14)
Alternative splicing (AS) is a mechanism of post-transcriptional regulation that plays an important role during development and in the maintenance of stem cell pluripotency. The dynamics of AS ...
Iannone, Camilla (Date of defense: 2014-05-23)
Intron removal is a necessary step for expression of most genes in higher eukaryotes, and alternative splice selection is a highly regulated mechanism that endows a single gene with the possibility to ...
López Oreja, Irene (Date of defense: 2022-03-01)
Mutations in Splicing Factor 3b Subunit 1(SF3B1) are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are associated with worse disease prognosis. SF3B1 is involved in pre-mRNA ...
Colì, Caterina (Date of defense: 2019-11-25)
Alternative splicing (AS) is an important step in the pathway of gene expression and regulation. The splicing process is catalyzed by the Spliceosome, a complex molecular machinery that is dynamically ...
Faleiro, Michelle R. (Date of defense: 2017-03-27)
Spinal Muscular Atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the degeneration of the lower motor neurons. It is caused by homozygous loss or mutations in the Survival ...
Tejedor Vaquero, Juan Ramón (Date of defense: 2014-06-11)
Alternative splicing is an essential regulatory layer of gene expression that expands the coding potential of the genome in multicellular organisms. The spliceosome -the sophisticated machinery involved ...
Martín Rodríguez, Elena (Date of defense: 2018-01-24)
A splicing network analysis that captured functional similarities among spliceosomal components, revealed a prominent core module containing splicing factors SPF45, SR140 and CHERP. We report that ...
Hernández Ribera, Jordi (Date of defense: 2016-11-23)
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative ...
575 - General genetics. General cytogenetics (4)
577 - Material bases of life. Biochemistry. Molecular biology. Biophysics (3)
576 - Cellular and subcellular biology. Cytology (2)
616.4 - Pathology of the lymphatic system, haemopoietic (haematopoietic) organs, endocrines (2)
616.6 - Pathology of the urogenital system. Urinary and sexual (genital) complaints. Urology (1)