Universitat Pompeu Fabra: Enviaments recents
Ara mostrant els elements 161-180 de 3276
Proximal junctional failure stratification in adult spine surgery using 3D patient-specific finite element models
Adult Spine Deformity (ASD) leads to abnormal spine curvature causing imbalance, pain, and fall risk. Spinal surgery is common but carries the risk of Mechanical Complications (MC), notably Proximal Junctional Failure ...
On the flexibility of the perception and cognition of broken harmonic expectations
La música està present en totes les cultures. Tot i tenir les mateixes habilitats auditives, la manera en la què experimentem la música depèn del context cultural, la música que escoltem en el dia a dia o si hem rebut ...
Diversity and evolution of South Pacific Eumolpinae (Coleoptera: Chrysomelidae) and the role of New Caledonia in their diversification
The South Pacific is an intriguing region for studying evolutionary biology, presenting an exceptional diversity and complex geological and environmental characteristics. New Caledonia, in particular, hosts a rich and ...
Lifestyle interventions and cognitive change: determinants and underlying mechanisms
Les intervencions que milloren l’estil de vida (dieta, exercici físic i entrenament cognitiu) poden frenar el declivi cognitiu en persones a risc de demència. En el context d’intervencions en l’estil de vida, aquesta ...
Computational engineering of biomolecules
Aquesta tesi presenta diversos avenços que inclouen: (i) noves funcionalitats afegides a la “suite” d'eines de disseny de proteïnes FoldX per permetre als usuaris treballar amb qualsevol tipus de molècula; (ii) estudis ...
Deciphering the nuclear function of folate enzyme MTHFD2 in cancer: a novel role for nuclear MTHFD2 in mitosis
Subcellular compartmentalisation of metabolic enzymes may elicit specific cellular functions by establishing a unique metabolic environment. Indeed, the nuclear translocation of certain metabolic enzymes impacts epigenetics ...
Dynamics of cellular decision making in embryogenesis
This thesis is about development and its study from a theoretical point of view, with special interest in how to describe development as a dynamical systems' problem. The thesis digs into four directions embedded in this ...
Information fusion and learning from diverse clinical cohorts and heterogeneus data
This PhD thesis explores how data science can be leveraged to learn from diverse cohorts and fuse information from heterogeneous data, aiming to advance understanding and improve prediction in healthcare settings. It covers ...
Processing of sentential meaning: behavioural and electroencephalographic evidence in neurotypical and Williams syndrome adult populations
Meaning in any naturalistic utterance has a dual aspect: one is lexical-semantic memory, which enters into utterances in the form of words that we remember and retrieve; the other is the specific kind of meaning carried ...
Multimodal phonetic training: the benefits of hand gestures on learning L2 sounds
In the realm of second language acquisition of pronunciation, perception-based phonetic training has been shown to be effective in improving L2 perception and production. By incorporating the visual modality of the speaker’s ...
Uncovering novel vulnerabilities of melanoma cells based on RNA regulation
La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten o inhibeixen la ...
Polycomb repressive complex 2 deregulation in tissue homeostasis and cancer
Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic lethality and disease, ...
La Premsa de proximitat cooperativa a Catalunya: orígens i revitalització d'un model d'empresa periodística
Els darrers quinze anys ha crescut l’experimentació amb els models d’organització periodística. La cooperativa és un dels més destacats. Malgrat que estiguin implantades arreu del món des de fa dècades, les cooperatives ...
Human population genetics of North Africa: insights into demography and functional variation
Since the origins of humankind, North Africa has been involved in many demographic events, leading to a heterogeneous cultural and genetic landscape. However, it is largely underrepresented in genetic studies, and many ...
The role of the expanded endocannabinoid system in cognitive impairments induced by prenatal and lactation alcohol exposure in mice
Alcohol exposure during gestation and lactation leads to physical and behavioral disabilities known as fetal alcohol spectrum disorder. Although cognitive dysfunction is highly frequent and compromises the patients’ quality ...
Modulation-enhanced localization microscopy: using patterned illumination for super-resolution microscopy: from the localization of single molecules to the descripton of nano-structures
This thesis introduces SIMPLE (Structured Illumination based Point Lo- calization Estimator), a novel super-resolution technique in fluorescence microscopy. By combining standing-wave patterned illumination with single-molecule ...
Cannabis modulation of social interaction in psychosis : neurobiological correlates in humans and mouse models
Els pacients diagnosticats amb esquizofrènia o un primer episodi psicòtic (PEP) que consumeixen cànnabis presenten alteracions clíniques diferencials comparats amb els no consumidors. En aquesta tesi doctoral, hem emprat ...
Mechanical control of epithelial tissue formation and function in early development
The outer epithelial layer is the first cell type that emerges during development, providing essential mechanical protection and is indispensable for morphogenesis. Here, we study how the interplay between molecular and ...
Phytocannabinoids and endocannabinoids as modulators of cocaine reinforcement in mice
Cocaine use profoundly disrupts the neuronal circuits that regulate reward processing, motivation and decision making, resulting in long-lasting neuroplastic adaptations in the mesocorticolimbic system. The endocannabinoid ...
Investigating the role of Gli2 in mouse embryonic stem cells and mouse embryogenesis
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
