Universitat Pompeu Fabra: Recent submissions
Now showing items 181-200 of 3325
The tumor-supressive role of RNF144B: a p53-activated E3 ligase guarding genomic stability
El conegut supressor tumoral p53 regula un ampli programa transcripcional que protegeix envers el càncer. No obstant, la complexitat d’aquest programa fa difícil determinar el rol de cada gen regulat per p53. Deplecionar ...
Sleep in the preclinical stages of Alzheimer's disease: a multimodal biomarkers approach
This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. ...
Work trajectories after a sickness absence due to cancer in Catalonia (Spain)
The project focuses on cancer and its effects on work trajectories from a life course perspective, both from a qualitative and quantitative approach. Quantitative analyses were based on a retrospective dynamic cohort of ...
NKG2A blockade as a potential strategy to improve NK cell-mediated ADCC in HER2+ breast cancer
Several studies support the contribution of antibody-dependent NK cell cytotoxicity (ADCC) to the clinical efficacy of anti-HER2 therapeutic antibodies in HER2-positive breast cancer. Novel anti-HER2 antibody drug conjugates ...
De novo genome assemblies of endagered species and challenging chromosomes
Modern biology relies on genomic references to perform analyses in most studies. High-quality de novo genome assemblies are key to having references containing all the genomic content of a species. Here I use avant-garde ...
Mechano-biochemical systems modelling for patient stratification in osteoarthritis
This doctoral thesis presents two different computational approaches to explore mechanistically chondrocyte dysregulation and identify biomarkers, to better understand patient stratification systems in primary knee ...
Detection of selection signals on regulatory units across human cancers
Tumor progression is dominated by two evolutionary forces: first mutagenesis, which provides the heritable variability where, secondly, natural selection acts. The main challenge of cancer genomics is to identify the somatic ...
Elementos para una teoría sobre las reglas constitutivas
Las reglas constitutivas son un instrumento teórico ampliamente analizado en la ontología social y en la teoría del derecho. Este trabajo busca revisar las principales posturas de la literatura, con el fin de comprender ...
Three Essays on Information and Learning in Financial Decisions
This dissertation consists of three chapters investigating the role of information and beliefs in financial markets and the macroeconomy. In the first chapter, I build a sequential trading model to analyze the dynamics ...
Essays in Macroeconometrics
This thesis consists of three chapters on topics in Macroeconometrics. Chapter 1 presents a method for online evaluation of the optimality of the current stance of monetary policy given the most up to date data available. ...
Moral Progress in Linguistic Pragmatism: On the Rortyan advocacy for greater human solidarity
Aquest estudi es proposa interrogar-se sobre la noció de progrés moral en el marc del pragmatisme lingüístic de Richard Rorty per tal de contribuir en el debat acadèmic actual a l’entorn d’aquest concepte. Al temps que ...
Essays on Learning Theory for time series
This thesis comprises three essays on statistical learning theory for time series. In the first chapter, joint with Christian Brownlees, we propose an alternative specification of a dynamic conditional correlation model ...
Towards stylised facts on international migration research: Immigrants' labor market integration, dynamics of remittance behaviour, and underlying mechanisms of migration rates
This thesis touches upon three subjects within international migration, namely: immigrants’ labour market incorporation, dynamics of remittances behaviour, and the role of migrant networks as an underlying mechanism of ...
A Comprehensive study of arithmetic circuits and elliptic curves for efficient and scalable zero-knowledge proof systems
In recent years, zero-knowledge proofs have come to play a crucial role in distributed systems where there is no trust between the parties involved. Most popular proof systems are for the NP-complete language of arithmetic ...
Multilingual adaptative text simplification
Reading is an essential skill that plays a crucial role in our daily lives. It allows us to access information, gain knowledge, expand our understanding of the world around us, and build the foundation for learning, ...
Towards a comprenhension of spatiotemporal brain dymamics in psychotic disorders a whole-brain computational perspective based on fMRI
Psychotic disorders are highly heterogeneous, complicating diagnosis and treatment. The mechanisms underlying these disorders are still unclear, and bridging the gap between neural properties and impairments remains a ...
Los límites del Derecho administrativo: Lineamientos para identificar su autonomía a partir de la teoría de sistemas
La tesis busca explicar cómo se determinan los límites del Derecho administrativo para derivar de allí una respuesta al asunto práctico del ámbito de aplicación de esta rama del Derecho. Se argumenta que la incompleta ...
El Derecho tributario ante el arbitraje internacional de inversiones: ¿hacia una nueva forma de resolver las disputas tributarias internacionales?
El creciente número de controversias tributarias bajo el mecanismo de arbitraje de inversiones pone de relieve la necesidad de un análisis exhaustivo del tratamiento de las cuestiones tributarias en los Acuerdos ...
Familias reconstituidas y formas de parentalidad: Un estudio jurídico-comparado para redefinir los lazos familiares
La presente tesis doctoral realiza una propuesta normativa para regular jurídicamente una relación socialmente muy diversa: la que se da entre un hijo o hija y la pareja de uno de sus progenitores o «adulto afín». La ...
Localization and participation: democracy from below
Localization and Participation: Democracy from Below analyses the emerging normative value of local governance and participatory democracy. Democratic legitimacy has, historically, been of little relevance to state and ...
