Universitat Pompeu Fabra: Recent submissions
Now showing items 221-240 of 3325
Uncovering novel vulnerabilities of melanoma cells based on RNA regulation
La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten o inhibeixen la ...
Polycomb repressive complex 2 deregulation in tissue homeostasis and cancer
Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic lethality and disease, ...
La Premsa de proximitat cooperativa a Catalunya: orígens i revitalització d'un model d'empresa periodística
Els darrers quinze anys ha crescut l’experimentació amb els models d’organització periodística. La cooperativa és un dels més destacats. Malgrat que estiguin implantades arreu del món des de fa dècades, les cooperatives ...
Human population genetics of North Africa: insights into demography and functional variation
Since the origins of humankind, North Africa has been involved in many demographic events, leading to a heterogeneous cultural and genetic landscape. However, it is largely underrepresented in genetic studies, and many ...
The role of the expanded endocannabinoid system in cognitive impairments induced by prenatal and lactation alcohol exposure in mice
Alcohol exposure during gestation and lactation leads to physical and behavioral disabilities known as fetal alcohol spectrum disorder. Although cognitive dysfunction is highly frequent and compromises the patients’ quality ...
Modulation-enhanced localization microscopy: using patterned illumination for super-resolution microscopy: from the localization of single molecules to the descripton of nano-structures
This thesis introduces SIMPLE (Structured Illumination based Point Lo- calization Estimator), a novel super-resolution technique in fluorescence microscopy. By combining standing-wave patterned illumination with single-molecule ...
Cannabis modulation of social interaction in psychosis : neurobiological correlates in humans and mouse models
Els pacients diagnosticats amb esquizofrènia o un primer episodi psicòtic (PEP) que consumeixen cànnabis presenten alteracions clíniques diferencials comparats amb els no consumidors. En aquesta tesi doctoral, hem emprat ...
Mechanical control of epithelial tissue formation and function in early development
The outer epithelial layer is the first cell type that emerges during development, providing essential mechanical protection and is indispensable for morphogenesis. Here, we study how the interplay between molecular and ...
Phytocannabinoids and endocannabinoids as modulators of cocaine reinforcement in mice
Cocaine use profoundly disrupts the neuronal circuits that regulate reward processing, motivation and decision making, resulting in long-lasting neuroplastic adaptations in the mesocorticolimbic system. The endocannabinoid ...
Investigating the role of Gli2 in mouse embryonic stem cells and mouse embryogenesis
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
Structural language change in Alzheimer's disease: a study of spontaneous speech tasks across different stages of cognitive impairment
Linguistic characteristics of spontaneous connected speech are showing increasing potential for detecting and tracking cognitive decline in Alzheimer’s disease, and could be particularly suitable to study at-risk populations ...
La Traducción chino-español de las metáforas sobre Relaciones de Género en la novela Wei Cheng (围城): un estudio desde la perspectiva del análisis del discurso
Wei Cheng (围城 ), una de las obras literarias más importantes de la China moderna, es ampliamente conocida por su estilo sarcástico y el uso de abundantes metáforas. Mediante un estudio de la traducción chino-español de las ...
Essays on agent heterogeneity in macroeconomics
In my Ph.D. thesis, I study the subjects of monetary economics, heterogeneity of households and firms, and optimal policy. I solve models with rich heterogeneity and use statistical models to work with time series macro ...
Essays in macroeconomics and economic geography
This dissertation contains three essays on macroeconomics and economic geography. In the first Chapter, I study the evolution of hours worked. I develop a model of the labor market and use the model to explain the evolution ...
Essays on trade agreements
This dissertation consists of two chapters studying trade agreements. The first chapter estimates the effects of preferential trade agreements on bilateral trade between their signatories. A novel empirical method used ...
Precarious employment and social reproduction: the impact on health and well-being
This dissertation aims to make a theoretical and empirical contribution to the debate on precarious employment, social reproduction and the impact on health and well-being. In recent years, numerous studies have examined ...
Comunicación efectiva de la ciencia a audiencias amplias : ¿una obligación, un reto o una oportunidad?
La Unión Europea ha detectado que los proyectos de ciencia e innovación financiados por el Programa Marco y sus resultados no siempre se comunican a audiencias amplias de forma adecuada, es decir a la sociedad y los medios. ...
Information propagation in the cortex across the sleep-wake cycle: a computational study
During the deep phases of sleep we do not normally wake up by a thunder, but we nevertheless notice it when awake. The exact same sound gets to our ears and cortex through the thalamus and still, it triggers two very ...
Essays in monetary economics
This thesis studies the optimal conduct of monetary policy in the presence of nominal and informational frictions. The first chapter studies the optimal policy in a small open economy model with external asset holdings. ...
Essays in macroeconomics and agents' heterogeneity
In my PhD thesis, I analyse different macro and policy-relevant heterogeneities across both firms and individuals. In the midst of vivid debate over the US college financial aid system, Chapter 1 shows that student loans ...
