Now showing items 1-20 of 75
Castro Gallegos, Jessica (Date of defense: 2010-10-26)
En aquesta tesi s'han estudiat les propietats antitumorals d'una variant de la ribonucleasa pancreàtica humana anomenada PE5 que incorpora un senyal de localització nuclear. Aquest estudi mostra que PE5 indueix l'apoptosi ...
Emran Khaled Abd El Aziz, Mohamed (Date of defense: 2012-12-03)
The work presented in this Doctoral Thesis has studied the temporal and spatial patterns of the most relevant soil parameters with special attention posed to soil biological and biochemical dynamics occurring at the studied ...
Guerrero Barrado, Pedro Enrique (Date of defense: 2020-07-29)
Pancreatic Ductal Adenocarcinoma (PDA), the most common pancreatic cancer, remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. Expression ...
García Galindo, Glòria (Date of defense: 2016-07-19)
Les ribonucleases són enzims que presenten citotoxicitat selectiva per a cèl·lules tumorals. S'ha proposat l’ús de ribonucleases dirigides a nucli (ND-RNases) com a fàrmacs antitumorals. En aquest treball s'ha caracteritzat ...
Carrion-Salip, Dolors (Date of defense: 2014-09-17)
Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these limitations through ...
Badosa Romañó, Esther (Date of defense: 2001-12-21)
Molts bacteris del grup fluorescent del gènere Pseudomonas són capaços de controlar malalties de les plantes causades per fongs i bacteris fitopatògens (ACBs) o mostren activitat com a bacteris promotors del creixement de ...
Panosa Roqueta, Clara (Date of defense: 2015-12-14)
The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that ...
Cadavid Tobón, Ana Maria (Date of defense: 2019-02-15)
The aim of this doctoral thesis was to evaluate the application of microbial transglutaminase (MTGase), produced by BDF Natural Ingredients, in the manufacture of acid and enzymatic coagulation fresh cheeses. In the case ...
Barral Fraga, Laura (Date of defense: 2017-10-26)
Based on the current knowledge about biofilm ecotoxicology and arsenic biogeochemistry in freshwater ecosystems, this thesis studied, under realistic environmental concentrations, i) the role of benthic biofilms in the ...
Osset Álvarez, Miguel (Date of defense: 2023-03-08)
Summary Nowadays, ammonium (NH4+) is a pollutant present in all kinds of water bodies, leading to multiple environmental and health issues. The current NH4+-removing technologies are very expensive, as they require a lot ...
Batlle Vilanova, Pau (Date of defense: 2016-11-25)
In 2015 the average concentration of CO2 in the atmosphere exceeded 400 ppm. Some technologies, including CO2 capture and storage, are palliative. However, the development of alternatives to burning of fossil fuels focuses ...
Cufí González, Sílvia (Date of defense: 2015-05-22)
Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics de les cèl•lules mare ...
Murcia Gubianas, Cristina (Date of defense: 2022-07-14)
La resposta inflamatòria d’un hoste pot ser excessiva o desregulada en relació a la intensitat o la durada d’una agressió. Quan aquesta resposta és secundària a una infecció es coneix com a sèpsia i pot acabar lesionant ...
Pous Rodríguez, Narcís (Date of defense: 2015-05-28)
The presence of nitrates (NO3-) in groundwater is a worldwide concern. The high energy demand and environmental impact of available technologies requires investigating new technologies. This thesis was focused on investigating ...
Rubiño Campoy, Susana (Date of defense: 2023-07-28)
Macroalgae have been recognized as an interesting source of compounds with multiple applications in different fields due to their various bioactivities since current trends are moving towards the use of alternative compounds ...
Tubert Juhé, Pere (Date of defense: 2012-07-24)
Ribonucleases are promising candidates for use in anticancer therapy. There are different ways to endow an RNase with antitumor properties. Targeting the enzyme to the cell nucleus is a potential approach. PE5 is a variant ...
Alemany Agulló, Jaume (Date of defense: 2001-10-20)
El principal objectiu d'aquest treball ha estat estudiar la producció de metabòlits amb activitat antibiòtica per soques de l'espècie Pseudomonas fluorescens de la col·lecció EPS, i també avaluar la seva potencialitat com ...
Mallorquí Fernández, Goretti (Date of defense: 2003-05-22)
Les dues proteïnes estudiades en aquest treball (ECP o RNasa 3 i RNasa 1ΔN7) pertanyen a la superfamília de la RNasa A i resulten d'especial interès per la seva potencial aplicació en la teràpia i/o diagnòstic del ...
Moreno González, M. del Carmen (Date of defense: 2006-11-27)
La soca EPS125 ha mostrat ser un efectiu agent de control biològic de diferents patògens fúngics de postcollita en diferents fruits. Degut a la seva elevada eficàcia, es va plantejar desenvolupar aquesta soca comercialment ...
Carbó Bagué, Anna (Date of defense: 2023-03-27)
In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of ...