Now showing items 80-97 of 97

    Regulome-seq: a novel approach for the identification of non-coding variants associated with human disease. Assessment of its applicability in 89 Brugada syndrome individuals 

    Pinsach Abuin, Mel·lina (Date of defense: 2019-01-30)

    Brugada syndrome (BrS) is a cardiac electrical disease with high susceptibility to sudden cardiac death. Approximately 25-30% of BrS patients are explained by pathogenic variants in coding sequences of cardiac ion channels, ...

    Reinterpretació de les variants genètiques identificades en una unitat especialitzada en cardiopaties familiars 

    Fernandez Falgueras, Anna (Date of defense: 2022-12-13)

    Sudden cardiac death (SCD) is defined as a natural and unexpected death due to cardiac etiology. In addition, when the cause of death remains unexplained after a complete autopsy, a cardiac arrhythmia is suspected as a ...

    Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida 

    Díaz Roldán, Ferran (Date of defense: 2023-07-03)

    Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...

    Relación entre el flujo de la arteria cerebral media y la presión en la arteria carótida interna durante la endarterectomía carotídea 

    Rodríguez Cabeza, Patricia (Date of defense: 2017-10-03)

    Risk of cerebral hypoperfusion during carotid endarterectomy arterial is the main limiting factor of this technique. Shunt allows partial maintenance of cerebral perfusion during clamping. We analyze the hemodynamic ...

    Relevance of the epigenetic regulation exercised by hepatic microRNAs in the fatty liver arena: from the bedside to the bench 

    Latorre Luque, Jèssica (Date of defense: 2020-03-04)

    Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, involving a spectrum of disturbances mainly characterized by fatty acid infiltration and fat deposition in the liver ...

    Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions 

    Muñoz San Martín, María (Date of defense: 2021-09-15)

    Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...

    Sistema immunitari i marcadors de risc cardiometabòlic en l'edat pediàtrica 

    Gispert-Saüch Puigdevall, Montse (Date of defense: 2018-03-02)

    We studied the relationship between the circulating levels of the innate immune system molecules (α-defensins and BPI) and the acquired immune system (IgG, IgA and IgM) with obesity and cardiometabolic risk factors in ...

    Statistical methods to manage and analyse real world data. Development of a health observatory in Alt Empordà 

    Franquet Bonet, Álvaro (Date of defense: 2021-12-01)

    The objective of this thesis is to explore in greater depth the process of creating a public health observatory and the processing of the information needed to take territorial decisions in the county of Alt Empordà. The ...

    Study of two analogues of pituitary adenylate cyclase-activating polypeptide as novel therapeutic compounds for Huntington’s disease 

    Solés Tarrés, Irene (Date of defense: 2023-06-14)

    Huntington’s disease (HD) is a neurodegenerative genetic disorder with no effective treatment characterized by motor discoordination, deficits in cognitive function (acquiring new knowledges, memory, understanding…), and ...

    The relevance of hydrogen sulfide (H2S) in obesity and adipose tissue physiology 

    Comas Vila, Ferran (Date of defense: 2021-05-14)

    Hydrogen sulfide (H2S), regarded as the third gasotransmitter, plays diverse physiological and pathological roles in the body along with another two gasotransmitters, including nitric oxide (NO) and carbon monoxide (CO). ...

    Therapeutic potential of pituitary adenylate cyclase-activating polypeptide and epigallocatechin gallate in motor and cognitive deficits of Huntington's disease models 

    Cabezas Llobet, Núria (Date of defense: 2019-02-28)

    Huntington's disease (MH) is a progressive neurodegenerative disorder characterized by a motor dysfunction, cognitive impairment, and psychiatric symptoms. At neuropathological level, it has been described that cognitive ...

    Trafficking and function of the voltage-gated sodium channel β2 subunit 

    Cortada Almar, Èric (Date of defense: 2020-11-24)

    The sodium channel β2 subunit is a component of the voltage-gated sodium channel (NaV), a large multimeric protein complex. In the heart, NaV is mainly composed of a pore-forming α subunit, NaV1.5, and two associated ...

    Utilidad de la resonancia magnética testicular con espectroscopía en el análisis cuantitativo de la infertilidad 

    Baleato González, Sandra (Date of defense: 2012-12-12)

    PURPOSE: To determine the role of MRI and MR spectroscopy (MRSI) in the diagnosis of infertility. To stablish normal values of the metabolites involved in the spermatogenesis (choline, creatine, and lipids) and to quantify ...

    Validesa del Sistema d’Informació pel Desenvolupament de la Investigació a Atenció Primària en l'estudi de malalties vasculars i estudi de l'efectivitat de les estatines en la reducció de mortalitat i malalties vasculars en la població major de 74 anys 

    Balló Peña, Elisabet (Date of defense: 2020-07-31)

    Electronic Health Record are legal documents where all the bio-psycho-social information of care received by the healthcare system is recorded throughout their lives. The first causes of death in Spain are cardiovascular ...

    Valoració dels canvis que pateix la uretra durant l’embaràs objectivats per ecografia 2D i la relació d’aquests amb l’aparició d’incontinència d’orina en la gestació 

    Carrera Boix, Alícia (Date of defense: 2022-11-04)

    Urinary incontinence (UI) is a dysfunction that has a very negative impact on the quality of life of women who suffer from it (low self-esteem, shame, restriction of social contacts, etc.). Different factors involved in ...

    Variantes genéticas y su relación con la progresión y el pronóstico de la cardiopatía isquémica 

    Zabalza Cerdeiriña, Michel (Date of defense: 2015-12-09)

    La enfermedad cardiovascular es un trastorno complejo, multifactorial, poligénico y con un importante componente ambiental. Este grupo de enfermedades, y en particular la cardiopatía isquémica, ocasionan una gran morbilidad ...

    Vigilancia de la salud de los trabajadores en el contexto de la prevención de riesgos laborales. Calidad y utilidad preventiva de los exámenes de salud 

    Rodríguez Jareño, Mari Cruz (Date of defense: 2016-07-08)

    Pocas publicaciones estudian la utilidad preventiva de los exámenes rutinarios de vigilancia de la salud de los trabajadores. Aplicando técnicas cuantitativas y cualitativas a la información proporcionada mediante ...

    WNT5A, SFRP5 y CRTC3: nuevas adipocinas relacionadas con la obesidad en la edad pediátrica 

    Soriano Rodríguez, Pilar (Date of defense: 2015-10-13)

    WNT5A is a protein with proinflammatory properties recently related to insulin resistance. It is believed that this protein might be regulated by SFRP5, which sequesters WNT5A exerting its anti-inflammatory actions and ...