Now showing items 201-220 of 234
Barranco Muñoz, Neus (Date of defense: 2020-06-22)
The regulated secretory pathway is a hallmark of professional secretory cells as neurons and endocrine cells. Significant peptidergic neurotransmitters as hormones, neurotrophins and growth factors are targeted to ...
Bonilla-Pons, Sergi A. (Date of defense: 2021-04-30)
Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, show regenerative ...
Sellarès Rubio, Arnau (Date of defense: 2022-11-16)
[spa] El diagnóstico de enfermedades humanas originadas a causa de variantes y mutaciones en el ADN de cada persona está experimentando un cambio de paradigma, desde la aproximación genética tradicional hacia una que ...
Pons Pons, Alba (Date of defense: 2021-12-16)
SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog of the Drosophila ...
Aragón Altarriba, Eric (Date of defense: 2013-12-13)
Cell fate is controlled by a multitude of signals and loss of this control has devastating consequences for living organisms. One of the key players in this network of signals is the TGF-beta family of cytokines. These ...
Pinacho Garcia, Raquel (Date of defense: 2015-07-17)
Psychotic disorders including bipolar disorder and schizophrenia are a leading cause of disability across the world but the underlying pathophysiological mechanisms remain poorly understood. Available treatments are ...
Gracia Latorre, Elena (Date of defense: 2023-06-01)
[eng] Enhancers are the master regulators of gene expression. Genes rely on them to be differentially expressed in different tissues, developmental time points or contexts. In recent years, it has been reported that although ...
Rodriguez Fos, Elias (Date of defense: 2020-07-15)
This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the analysis of biological ...
Gonzàlez Juncà, Alba (Date of defense: 2013-11-15)
The TGF-beta oncogenic effect has been widely studied. In glioma, TGF-beta has an oncogenic role increasing cell proliferation and glioma-initiating cell (GIC) self-renewal capacity. During the investigation of this thesis, ...
Molina Jordán, Marc (Date of defense: 2023-12-04)
[eng] The application of mechanical force to the nucleus has been recently shown to regulate important functions, including nucleocytoplasmic transport (NCT), chromatin organization, and gene expression. However, how ...
González Gobartt, Elena (Date of defense: 2019-11-29)
Body axis elongation is a hallmark of the vertebrate embryo, which also comprises the morphogenesis of the caudal neural tube (NT). The contribution of bipotential neuromesodermal progenitors (NMPs) to the cranio-caudal ...
Guindo Martínez, Marta (Date of defense: 2019-12-18)
Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci account for a small ...
Salinas Pena, Mónica (Date of defense: 2023-09-20)
[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous H1 variants in T47D ...
Metallinou, Margarita (Date of defense: 2014-07-17)
The arid areas of North Africa and Arabia cover a surface of more than 13 million square kilometers and are characterized by their extreme temperatures, diversity of desert habitats and well-adapted flora and fauna. The ...
Mecho Lausac, Ariadna (Date of defense: 2014-10-15)
The study of the non-crustacean invertebrates dwelling on the deep Mediterranean Sea is of interest for different marine science disciplines, being the diversity of species and their distributions largely unexplored. In ...
Ramponi, Valentina (Date of defense: 2024-03-15)
[eng] Anti-cancer therapies are based on the infliction of damage or stress to cancer cells, with the aim of triggering cell death. In practice, a fraction of cancer cells often evades cell death and enters a state of cell ...
Guberović, Iva (Date of defense: 2021-10-01)
The histone variant macroH2A is the only structural chromatin component containing a macrodomain. In vertebrates, two genes and one event of alternative splicing give rise to three macroH2A proteins that differ in their ...
Ezquerra González, Artur (Date of defense: 2019-06-27)
Microtubules (MTs) mediate a range of essential cellular processes including cell division, intracellular transport and organelle positioning, by forming specifically adapted arrays. Assembly, maintenance and remodelling ...
Rasti Zaghiyan, George (Date of defense: 2021-09-20)
The Sirtuin family of NAD+-dependent enzymes plays a key role in the maintenance of genome integrity upon stress. Sirtuins coordinate the response to different forms of stress at different levels and have been involved ...
Puerto Plasencia, Marta (Date of defense: 2022-04-01)
It has been previously shown that the Drosophila heterochromatin protein 1c (HP1c) forms a complex with the transcription factors (TF) WOC and ROW, and the extraproteasomal ubiquitin receptor dDsk2. The HP1c-complex localizes ...