Universitat de Barcelona
Mostrando ítems 82-101 de 234
1) Estudio teórico de nucleobases modificadas. Las modificaciones químicas de ácidos nucleicos tienen una amplia variedad de aplicaciones tanto en clínica, utilizadas como agentes antisentido, así como en el estudio ...
El empaquetamiento del ADN en fibras de cromatina implica una gran cantidad de deformaciones geométricas de la doble hélice (enrollamiento y superenrollamiento del ADN) y la formación de una jerarquía de asas o dominios ...
El ictus es una enfermedad compleja que afecta al cerebro y al sistema vascular. Esta enfermedad tiene una alta mortalidad, siendo la segunda causa de muerte a nivel mundial y la primera causa de discapacidad en adultos ...
La tesi doctoral té com a eixos vertebradors la sistemàtica molecular, la biogeografia i la filogeografia molecular. S’han seleccionat dos grups de plantes per les interessants qüestions que presenten per resoldre i perquè ...
[spa] Tanto las variantes patogénicas como las epimutaciones constitucionales en los genes del sistema de reparación de errores de apareamiento (mismatch repair, MMR), MLH1, MSH2, MSH6 y PMS2, son responsables de los ...
En el mar Mediterráneo existen hábitats especialmente productivos como los fondos de maërl y de agregación de crinoideos, que son explotados en la actualidad por la flota de arrastre. Esta actividad supone un impacto que ...
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental methods for ...
[eng] Treatment landscape in early-stage NSCLC is rapidly changing after approval of anti-PD-1/PD-L1 in the neoadjuvant and adjuvant settings, respectively. However, biomarkers for patient selection, to predict response ...
A major challenge in evolutionary biology is understanding the main drivers that underlie morphological and species diversity. Ecological opportunity—access to new or previously inaccessible niches—has been identified as ...
The general aim of this dissertation is to investigate the evolution, the diversification and some ecological traits of the species of the strictly subterranean genus Troglocharinus Reitter, 1908. The genus Troglocharinus ...
The study of intraspecific diversity is essential in ecology and evolution as they reveal fine-scale patterns and it is crucial in conservation planning. The main aim of this thesis is to study the evolutionary history of ...
Many topics in ecology and evolution are currently being studied under the framework of eco- evolutionary dynamics that is to say integrating genetic, ecological and demographic data. Here, I have focused my investigations ...
[eng] Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive soft-tissue sarcomas. They usually appear in the clinical context of Neurofibromatosis type 1 (NF1), however, they also occur at a low frequency in the ...
La cromatina és una estructura nucleoproteïca dinàmica i jeràrquicament organitzada dins del nucli cel·lular. Segons la seva funcionalitat, la cromatina es pot classificar en dos tipus de regions: l’eucromatina, també ...
INTRODUCTION: Patients with chronic respiratory disease (CRDs) have a disorder in muscle structure and function, but their function increases with physical progress and decreases the risk of general and muscular weakness. ...
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast activation into ...
Glucose transporters (GLUTs) are extremely important for glucose metabolism. Glucose transporters uptake glucose from blood stream into the cells where it can be metabolized. Among the glucose transporters family, GLUT4, ...
[eng] One of the major and most challenging goals of Biomedicine during the last centuries has been the study of the human biological mechanisms, and its relation with traits and diseases. Particularly, in the case of ...
Taking into consideration the current knowledge about the subjects treated, several goals were proposed for this PhD thesis in order to further understand PHF8 function in both astrocytes and neural stem cells biology. To ...
Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common kind of variation ...
