Now showing items 202-221 of 229
Pinacho Garcia, Raquel (Date of defense: 2015-07-17)
Psychotic disorders including bipolar disorder and schizophrenia are a leading cause of disability across the world but the underlying pathophysiological mechanisms remain poorly understood. Available treatments are ...
Gracia Latorre, Elena (Date of defense: 2023-06-01)
[eng] Enhancers are the master regulators of gene expression. Genes rely on them to be differentially expressed in different tissues, developmental time points or contexts. In recent years, it has been reported that although ...
Rodriguez Fos, Elias (Date of defense: 2020-07-15)
This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the analysis of biological ...
Gonzàlez Juncà, Alba (Date of defense: 2013-11-15)
The TGF-beta oncogenic effect has been widely studied. In glioma, TGF-beta has an oncogenic role increasing cell proliferation and glioma-initiating cell (GIC) self-renewal capacity. During the investigation of this thesis, ...
Molina Jordán, Marc (Date of defense: 2023-12-04)
[eng] The application of mechanical force to the nucleus has been recently shown to regulate important functions, including nucleocytoplasmic transport (NCT), chromatin organization, and gene expression. However, how ...
González Gobartt, Elena (Date of defense: 2019-11-29)
Body axis elongation is a hallmark of the vertebrate embryo, which also comprises the morphogenesis of the caudal neural tube (NT). The contribution of bipotential neuromesodermal progenitors (NMPs) to the cranio-caudal ...
Guindo Martínez, Marta (Date of defense: 2019-12-18)
Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci account for a small ...
Salinas Pena, Mónica (Date of defense: 2023-09-20)
[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous H1 variants in T47D ...
Metallinou, Margarita (Date of defense: 2014-07-17)
The arid areas of North Africa and Arabia cover a surface of more than 13 million square kilometers and are characterized by their extreme temperatures, diversity of desert habitats and well-adapted flora and fauna. The ...
Mecho Lausac, Ariadna (Date of defense: 2014-10-15)
The study of the non-crustacean invertebrates dwelling on the deep Mediterranean Sea is of interest for different marine science disciplines, being the diversity of species and their distributions largely unexplored. In ...
Guberović, Iva (Date of defense: 2021-10-01)
The histone variant macroH2A is the only structural chromatin component containing a macrodomain. In vertebrates, two genes and one event of alternative splicing give rise to three macroH2A proteins that differ in their ...
Ezquerra González, Artur (Date of defense: 2019-06-27)
Microtubules (MTs) mediate a range of essential cellular processes including cell division, intracellular transport and organelle positioning, by forming specifically adapted arrays. Assembly, maintenance and remodelling ...
Rasti Zaghiyan, George (Date of defense: 2021-09-20)
The Sirtuin family of NAD+-dependent enzymes plays a key role in the maintenance of genome integrity upon stress. Sirtuins coordinate the response to different forms of stress at different levels and have been involved ...
Puerto Plasencia, Marta (Date of defense: 2022-04-01)
It has been previously shown that the Drosophila heterochromatin protein 1c (HP1c) forms a complex with the transcription factors (TF) WOC and ROW, and the extraproteasomal ubiquitin receptor dDsk2. The HP1c-complex localizes ...
Colmenero Ginés, Ana Isabel (Date of defense: 2017-11-10)
In the northwestern Mediterranean Sea, anglerfishes Lophius budegassa Spinola, 1807 and Lophius piscatorius Linnaeus, 1758 are among the most valuable demersal species and support an important fishery. Both anglerfishes ...
Varga Pastor, Herminia de la (Date of defense: 2013-11-29)
The availability of most edible ectomycorrhizal mushrooms depends on their natural fructification. Therefore, mycorrhizal plant production could be an alternative for obtaining ectomycorrhizal edible fungi. The first step ...
Tristán Noguero, Alba (Date of defense: 2019-11-22)
Monoamine Neurotransmitter diseases are a rare group of inherited disorders of metabolism that encompass 12 different genetic defects leading to abnormal dopamine and/or serotonin brain homeostasis. They correspond to ...
Sabbaghi Mehrjardi, Mohammad Ali (Date of defense: 2017-09-19)
Trastuzumab-emtansine (T-DM1) is an antibody-cytotoxic agent (DM1) conjugated drug. DM1 delivery by trastuzumab inside the HER2 positive cells affects microtubule polymerization, cell cycle arrest and finally cell death. ...
Tello Velasco, Daniel (Date of defense: 2023-09-19)
[eng] For this purpose, Spatial Analysis of Functional Enrichment (SAFE) framework was proposed to uncover functional regions in a network by embedding it in 2-dimensions (2D) using the Spring embedding algorithm. However, ...
Santos Tapia, Celia (Date of defense: 2019-10-30)
Aneuploidy, defined as a chromosome number that deviates from a multiple of the haploid set, is a common feature in human cancer, and around 70% of human solid tumours are aneuploid. The resulting metabolic imbalance is ...