Universitat de Barcelona
Ara mostrant els elements 1-20 de 63
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded in the structure, ...
DYRK1A es un gen del cromosoma 21 humano que codifica para una proteína quinasa constitutivamente activa que fosforila a sustratos que son clave en el desarrollo del cerebro. La proteína DYRK1A regula el crecimiento del ...
El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual se mantiene la ...
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods based on in vivo ...
[eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major sub processes: the ...
[eng] The main goals of this PhD thesis are closely related within the field of CDases and their key role in the regulation of sphingolipid metabolism. Thus, the roles of ACER3 and AC in different human diseases are of ...
Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively investigated, its ...
The connection between DNA folding and chromatin conformation has been much studied but the relation between the modulation of chromatin conformation and biological processes such as DNA damage, cell differentiation and ...
[eng] The skin epidermis is a continuously renewing tissue that requires a tightly regulated balance between keratinocyte proliferation and terminal differentiation to ensure proper structure and function. Despite substantial ...
[eng] Advances in capturing technologies have yielded a massive production of large-scale molecular data that describe different aspects of cellular functioning. These data are often modeled as networks, in which nodes are ...
Somatic mutations are those that arise after the zygote is formed and are therefore inherited by a fraction of the cells of an individual. Their relevance in certain skin diseases has been known for almost half a decade ...
The incremental application of supercomputers to offer solutions to complex problems has motivated the usage of computational modeling tools in drug design pipelines. Specifically, small low-affinity compounds are modified ...
1. El paper que tenen les ceramidases en diferents malalties humanes va guanyant interès. Tot i així, la recerca en aquest àmbit ha estat obstaculitzada per la manca d’inhibidors i substrats específics per les diferents ...
This work aims to analytically understand the impact of two diametric opposite environments on protein structure and dynamics and compared them to the most common solvent on earth: water. The first environment is a popular ...
The Cytoplasmic Polyadenylation Element Binding (CPEB)-family of RNA-binding proteins is composed of four paralogs in mammals, CPEB1-4. The CPEBs control the translation of the targeted mRNAs by modulating the length of ...
Se han estudiado los niveles de aminoácidos individuales (lactato, glucosa, glicerol, etc.) en plasma y actividad de GLU-deshidrogenasa, ASP-transaminasa, ALA-transaminasa, TYR-transaminasa, GLN-sintetasa, SER-deshidratasa, ...
L’obesitat és una patologia crònica que en les darreres dècades s’ha incrementat de manera alarmant al món especialment en els països mes desenvolupats. Malgrat que la dieta i l’exercici físic són dos agents primordials ...
La pancreatitis aguda és un procés inflamatori del pàncrees desencadenat per una activació inapropiada dels enzims pancreàtics. En la seva variant més severa, la malaltia progressa acompanyada d’afectacions no només a ...
[spa] El objetivo general de este trabajo de tesis doctoral ha sido progresar en el desarrollo de biomarcadores para el estudio de pacientes con enfermedades mitocondriales. Los objetivos concretos han sido los ...
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental methods for ...
