Biological applications of discrete molecular dynamics 

    Sfriso, Pedro (Date of defense: 2016-03-18)

    Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded in the structure, ...

    Caracterización de las alteraciones estructurales y funcionales de la corteza cerebral de ratones mutantes de pérdida y ganancia de función de DYRK1A 

    Arranz Villacañas, Juan (Date of defense: 2016-12-16)

    DYRK1A es un gen del cromosoma 21 humano que codifica para una proteína quinasa constitutivamente activa que fosforila a sustratos que son clave en el desarrollo del cerebro. La proteína DYRK1A regula el crecimiento del ...

    Caracterización molecular del reflejo inflamatorio y modulación de la respuesta inmune frente a infecciones en peces 

    Torrealba Sandoval, Débora Alejandra (Date of defense: 2016-06-03)

    El mantenimiento de la homeostasis del sistema inmune innato es fundamental, ya que éste debe mantener una respuesta equilibrada frente a los patógenos. En mamíferos, uno de los mecanismos por el cual se mantiene la ...

    Cell-extrinsic barriers of cellular plasticity: contribution of natural killer cells, T lymphocytes and vitamin B12 to in vivo reprogramming 

    Meléndez Esteban, Elena (Date of defense: 2022-03-24)

    The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods based on in vivo ...

    Characterization of mRNA expression and localization in synaptic plasticity 

    Mendoza Blanco, Mónica (Date of defense: 2023-11-24)

    [eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major sub processes: the ...

    Chemical tools for the study of sphingolipid metabolism in diseases 

    Aseeri, Mazen (Date of defense: 2023-03-13)

    [eng] The main goals of this PhD thesis are closely related within the field of CDases and their key role in the regulation of sphingolipid metabolism. Thus, the roles of ACER3 and AC in different human diseases are of ...

    Compound F: A novel nuclear receptor modulator and its potential application on hematologic malignancies 

    Ruiz Cánovas, Eugenia (Date of defense: 2018-12-10)

    Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively investigated, its ...

    Comprehensive study of 3D chromatin structure 

    Lema Amado, Rafael (Date of defense: 2020-11-19)

    The connection between DNA folding and chromatin conformation has been much studied but the relation between the modulation of chromatin conformation and biological processes such as DNA damage, cell differentiation and ...

    Deciphering the functional organization of molecular networks via graphlets-based methods and network embedding techniques 

    Doria Belenguer, Sergio (Date of defense: 2023-10-07)

    [eng] Advances in capturing technologies have yielded a massive production of large-scale molecular data that describe different aspects of cellular functioning. These data are often modeled as networks, in which nodes are ...

    Detection of somatic variants from genomic data and their role in neurodegenerative diseases 

    Lobón García, Irene (Date of defense: 2019-07-26)

    Somatic mutations are those that arise after the zygote is formed and are therefore inherited by a fraction of the cells of an individual. Their relevance in certain skin diseases has been known for almost half a decade ...

    Development and application of computer-aided strategies for virtual screening and hit-to-lead 

    Perez Lopez, Carles (Date of defense: 2022-07-13)

    The incremental application of supercomputers to offer solutions to complex problems has motivated the usage of computational modeling tools in drug design pipelines. Specifically, small low-affinity compounds are modified ...

    Eines per a l'estudi del metabolisme i els efectes dels esfingolípids 

    Bielsa i Vilardaga, Núria (Date of defense: 2021-06-22)

    1. El paper que tenen les ceramidases en diferents malalties humanes va guanyant interès. Tot i així, la recerca en aquest àmbit ha estat obstaculitzada per la manca d’inhibidors i substrats específics per les diferents ...

    Environment matters : the impact of urea and macromolecular crowding on proteins 

    Candotti, Michela (Date of defense: 2016-12-09)

    This work aims to analytically understand the impact of two diametric opposite environments on protein structure and dynamics and compared them to the most common solvent on earth: water. The first environment is a popular ...

    Essential functions of Cpeb4 in tissue homeostasis 

    Maíllo Carbajo, Carlos (Date of defense: 2016-06-21)

    The Cytoplasmic Polyadenylation Element Binding (CPEB)-family of RNA-binding proteins is composed of four paralogs in mammals, CPEB1-4. The CPEBs control the translation of the targeted mRNAs by modulating the length of ...

    Estudi d'alguns aspectes del metabolisme dels aminoàcids en la rata després del part 

    Remesar Betlloch, Xavier (Date of defense: 1979-01-01)

    Se han estudiado los niveles de aminoácidos individuales (lactato, glucosa, glicerol, etc.) en plasma y actividad de GLU-deshidrogenasa, ASP-transaminasa, ALA-transaminasa, TYR-transaminasa, GLN-sintetasa, SER-deshidratasa, ...

    Estudi de l'oncostatina M i de la termogènesi del teixit adipós marró, abans i després de la cirurgia bariàtrica 

    Piquer García, Irene (Date of defense: 2020-01-22)

    L’obesitat és una patologia crònica que en les darreres dècades s’ha incrementat de manera alarmant al món especialment en els països mes desenvolupats. Malgrat que la dieta i l’exercici físic són dos agents primordials ...

    Estudi dels exosomes com a mecanisme de comunicació intercel·lular en patologies pancreàtiques 

    Bonjoch Gassol, Laia (Date of defense: 2017-02-03)

    La pancreatitis aguda és un procés inflamatori del pàncrees desencadenat per una activació inapropiada dels enzims pancreàtics. En la seva variant més severa, la malaltia progressa acompanyada d’afectacions no només a ...

    Estudio de biomarcadores en los defectos de la fosforilación oxidativa mitocondrial y en las deficiencias de coenzima CoQ10 

    Paredes Fuentes, Abraham José (Date of defense: 2022-12-01)

    [spa] El objetivo general de este trabajo de tesis doctoral ha sido progresar en el desarrollo de biomarcadores para el estudio de pacientes con enfermedades mitocondriales. Los objetivos concretos han sido los ...

    Evaluating protein folding predictions and functional annotations: A comprehensive analysis of recent advancements in the protein structural field 

    Ruiz Serra, Victoria Isabel (Date of defense: 2023-11-08)

    [eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental methods for ...

    Evaluation of immunebiomarkers in Lung Cancer 

    da Rocha, Pedro Filipe Simões (Date of defense: 2022-11-25)

    [eng] Treatment landscape in early-stage NSCLC is rapidly changing after approval of anti-PD-1/PD-L1 in the neoadjuvant and adjuvant settings, respectively. However, biomarkers for patient selection, to predict response ...