Facultat de Biologia: Enviaments recents
Ara mostrant els elements 61-80 de 235
Caracterització de les activitats triacilglicerol ester hidrolases en miòcits aïllats de cor de rata
En células aisladas de corazón de rata se caracterizaron las actividades triacilglicerol ester hidrolasas. Se detecta la presencia de actividad acida localizada en el interior de los lisosomas, que no es sensible ni a la ...
Liquid-liquid phase separation in gene regulation and disease
Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation (LLPS). The structures ...
Three-dimensional organization of HP1c-complex target genes
It has been previously shown that the Drosophila heterochromatin protein 1c (HP1c) forms a complex with the transcription factors (TF) WOC and ROW, and the extraproteasomal ubiquitin receptor dDsk2. The HP1c-complex localizes ...
Post-transcriptional control of anti-tumor immune responses
Translation of mRNAs into proteins is a highly regulated step of gene expression. In cancer, post-transcriptional and translational control have a critical effect on transformation, controlling proliferation, survival, ...
Investigating genetic and mechanistic interactors in familial cardoimyopathy through advanced disease modeling
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and a frequent cause of heart failure and sudden cardiac death. HCM is a highly complex condition defined by clinical and genetic heterogeneity. ...
Cell-extrinsic barriers of cellular plasticity: contribution of natural killer cells, T lymphocytes and vitamin B12 to in vivo reprogramming
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods based on in vivo ...
Unravelling genetic predisposition to familial breast and ovarian cancer: new susceptibility genes and variant interpretation by in silico approaches
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision treatment measures. ...
Acoustic monitoring: new applications for bird and human wildlife conflicts monitoring
In a context of the global biodiversity crisis, such as the one in which the planet is found, having accurate information linked to biodiversity monitoring systems is essential to be able to make evidence-based decisions. ...
SLIMP: a mitochondrial protein involved in cell cycle regulation
SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog of the Drosophila ...
Molecular analysis of MTOC assembly - the role of ninein-like protein
Despite decades of work, the molecular requirements underlying microtubule- organizing center (MTOC) formation at the centrosome remain obscure. Progress is hindered by the complexity of this organelle, which is composed ...
Genetic and epigenetic insights into colorectal tumorigenesis
Colorectal cancer (CRC) is a major health burden with large numbers of new cases worldwide and high disease-specific mortality, despite great advances made towards improving patient clinical outcomes. It arises through the ...
Identification and characterization of new complex patterns of structural DNA and RNA alterations in cancer
Human cancer arises as a result of genomic alterations that transform cells and make them to grow without control and to pathological levels. The characterization of such genomic changes has enabled understanding tumor ...
Mechanisms that regulate intracellular DNA entanglement
Topoisomerase II often produces DNA knots and catenates when its DNA strand passage activity equilibrates the topology of intracellular DNA. However, these DNA entanglements are detrimental for the normal development of ...
Estudio de biomarcadores celulares para la implementación de terapias personalizadas en Fibrosis Quística
La Fibrosis Quística (FQ) es una enfermedad autosómica recesiva que ocurre cuando existen variantes patogénicas bialélicas en el gen Cystic Fibrosis Transembrane Regulator (CFTR), y que codifica por una proteína con el ...
Mejora del control biológico por conservación de las plagas que afectan a cultivos hortofrutícolas
Esta tesis se ha enfocado en evaluar el potencial de mejora del control biológico por conservación en huertos frutales y hortícolas en Cataluña, mediante la integración de infraestructuras ecológicas que promuevan y ...
The environmental change in coastal ecosystems during the Late Holocene as recorded in seagrass sedimentary archives
Coastal ecosystems, especially the vegetated areas, are among the most threatened ecosystems in the world, undergoing a fast and constant decline. Their losses are of serious concern due to their elevated production, ...
Genomic analysis of an introduced ascidian and implications for invasiveness
Invasive species constitute a major threat to global biodiversity and cause important economic losses and ecological impacts. In the marine realm, ascidians include several aggressive invasive species, some of which have ...
Eines per a l'estudi del metabolisme i els efectes dels esfingolípids
1. El paper que tenen les ceramidases en diferents malalties humanes va guanyant interès. Tot i així, la recerca en aquest àmbit ha estat obstaculitzada per la manca d’inhibidors i substrats específics per les diferents ...
Secretory markers of dense-core vesicles in Alzheimer's disease
The regulated secretory pathway is a hallmark of professional secretory cells as neurons and endocrine cells. Significant peptidergic neurotransmitters as hormones, neurotrophins and growth factors are targeted to ...
The role of behavioural and feedback mechanisms in mediating herbivory processes in Mediterranean seagrass ecosystems
The role of consumer-resource relationship is the basis of the structure and functioning of ecological communities. The traditional lens for studying such interactions have tended to omit the importance of the species ...
