Facultat de Biologia: Recent submissions
Now showing items 81-100 of 235
Gene regulatory networks in pancreatic islets and insulinoma
Insulinomas are extremely rare pancreatic neuroendocrine (PNET) tumours that develop from the β-cells of the pancreas.β-cells are the only cells capable of producing the hormine insulin, and play a major role in glucose ...
The metabolic aspects of macroH2A histone variants
The histone variant macroH2A is the only structural chromatin component containing a macrodomain. In vertebrates, two genes and one event of alternative splicing give rise to three macroH2A proteins that differ in their ...
Hydrometeorological and climatic control over lake phytoplankton: the importance of time scales
In the present thesis we focus on the two extremes of the wind speed – storms and atmospheric stilling – and analyse their impacts on lake environments and phytoplankton dynamics over short and long periods. As we realised ...
The role of SIRT1 and SIRT6 in epigenetic regulation of genome stability under stress
The Sirtuin family of NAD+-dependent enzymes plays a key role in the maintenance of genome integrity upon stress. Sirtuins coordinate the response to different forms of stress at different levels and have been involved ...
Integrating agriculture and conservation: The value of fallow land and its management for farmland and steppe bird conservation
Extensive farmland ecosystems are widespread and biodiversity-rich, yet they face important human pressures since the beginning of agriculture intensification, which is leading them into a severe biodiversity crisis. As a ...
Analysis of the contribution of Barrier-to-Autointegration Factor (BAF) to centromere function and mitosis progression
This work is focused on Barrier-to-Autointegration Factor (BAF) protein. BAF is a nuclear envelope (NE) component that binds chromatin and is required for NE reassembly (NER) at mitosis exit. Previous work in our group ...
Comprehensive identification and characterisation of germline structural variation within the Iberian population
One of the central aims of biology and biomedicine has been the characterisation and understanding of genetic variation across humans, to answer important evolutionary questions and to explain phenotypic variability ...
Investigating the role of mitochondrial dysfunction in the pathogenesis of Parkinsons´s disease using patient-specific derived astrocytes
Parkinson’s disease (PD) is an incurable, chronically progressive disorder of old age leading to premature invalidity and death. Clinically, PD is characterized by classical motor syndrome linked to a progressive loss of ...
An epigenetic approach to fatty acid metabolism in haematological malignancies
The role of fatty acids to overcome stress and contribute to disease progression is becoming increasingly evident in haematological diseases. Further, epigenetic factors play an important role in the aetiology of myelodysplastic ...
Role of Capicua-L in RTK signaling and endocycle regulation
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, Cic is expressed as ...
Setting up stem cell therapy for human retina: from organotypic cultures to cell fusion understanding
Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, show regenerative ...
Cambios en la capacidad funcional producidos por la hemodiafiltración "on-line"
Las personas con insuficiencia renal crónica (ERC) suelen manifestar sentirse más fatigados al terminar la sesión de diálisis (HD). Cabe destacar que se trata de una población compuesta por pacientes que pueden presentar ...
Function of the histone demethylase PHF8 in neural progenitor cells and glial differentiation
Taking into consideration the current knowledge about the subjects treated, several goals were proposed for this PhD thesis in order to further understand PHF8 function in both astrocytes and neural stem cells biology. To ...
Proteomic profile in postmortem brain in chronic schizopfrenia
Schizophrenia is a complex psychiatric disorder involving dysregulation of multiple pathways. In the last decades, the cortico-cerebellar-thalamo-cortical circuit has been proposed to play a key role in cognitive impairments ...
Factors implicats a l’estructura de l’heterocromatina constitutiva pericèntrica
La cromatina és una estructura nucleoproteïca dinàmica i jeràrquicament organitzada dins del nucli cel·lular. Segons la seva funcionalitat, la cromatina es pot classificar en dos tipus de regions: l’eucromatina, també ...
Biodiversidad, biogeografía y patrones evolutivos en crustáceos (Anomura, Galatheoidea) de zonas tropicales y templadas
The present dissertation addresses the study of the diversity, systematics, biogeography and evolutionary history of squat lobster superfamily Galatheoidea, founded on integrative taxonomy criteria. Squat lobsters are a ...
In silico design of antibodies for biomedical applications
Proteins are large macromolecules constituted by amino acids that are responsible for most of the biological processes within a cell. Proteins showing high complementary affinity may bind forming protein-protein complexes. ...
Patterns of activity in marine planktonic copepods: diel rhythms and driving factors
Marine planktonic copepods play a key ecological role in pelagic food webs. The study of their patterns of activity is fundamental in order to better understand the processes involved in the transfer of energy from lower ...
Functional interplay between ER and MAF transcription factors in breast cancer bone metastasis
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
Modeling neurofibromatosis type1 neurofibroma composition and formation
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the peripheral nervous ...
