Universitat de Barcelona
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La detecció precoç de fibrosi hepàtica és de gran rellevància per al diagnòstic i el tractament dels pacients amb una malaltia hepàtica crònica. Actualment, s'utilitzen diversos procediments per a la seva estadificació. ...
Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- Rich superfamily, ...
[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised by deficiency of ...
Huntington’s disease (HD) is a neurodegenerative disorder caused by an autosomic mutation on the Huntingtin (HTT) coding gene. HD is mainly characterized by the appearance of motor symptoms or choreas, which are associated ...
[spa] Debido a la importancia de la modulación del NMDAR, en el grupo de investigación de proteínas (GRIP) se han diseñado una serie de péptidos derivados de la Conantokina-G (Con-G), un péptido antagonista de los NMDARs, ...
A Schizosaccharomyces pombe, la citocinesi està mediada per l’assemblatge i la constricció de l’anell contràctil d’actomiosiona. Pertorbacions petites en aquesta estructura activen un conjunt de mecanismes de control que ...
[eng] INTRODUCTION: The Kirsten rat sarcoma oncogene (KRAS) homologue stands out as a prominent oncogene, distinguished by its notably elevated mutation rate compared to other oncogenes. This genetic anomaly is intricately ...
Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that affects between 1.5 and 17.2 in 100.000 live births. MFS is caused by mutations in the extracellular matrix (ECM) glycoprotein ...
[eng] KIT (CD117) is a tyrosine kinase receptor expressed in hematopoietic progenitors, melanocytes, germ cells, mast cells, and interstitial cells of Cajal (ICC) of the digestive tract. KIT gain-of-function mutations have ...
Homeostasis of the hematopoietic stem/progenitor cell pool relies on a finely tuned balance between self-renewal, differentiation and proliferation. Recent work has revealed the importance of mitochondria during stem cell ...
[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La característica ...
[eng] The hypothesis underlying the AMBAR study research seeks to evaluate the clinical efficacy of PE, in combination with albumin and intravenous immunoglobulin replacement (IVIG), as a treatment for Alzheimer's disease ...
L’aplicació de tècniques d’alt rendiment, com la transcriptòmica i la proteòmica, en l’estudi de l’espermatozoide humà, ha permès obtenir grans avenços en la coneixença de la seva composició i funció normal, així com ...
El nostre grup ha identificat prèviament diferents gens i programes transcripcionals regulats per la proteïna p27. En aquest treball ens centrem en el paper de la proteïna p27 en la regulació a nivell transcripcional de ...
Les proteïnes de la família de les CaM quinases (CAMK en anglès), l’activitat de les quals és dependent del complex calci-calmodulina, estan implicada en funcions cel·lulars com la regulació de l’expressió gènica, la ...
The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During the last years, the ...
This thesis investigates the mechanisms that are activated in response to replication stress induced with hydroxyurea, an agent that causes deoxyribonucleotides depletion and arrest cells in S phase, in the non-transformed ...
[eng] RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer’s disease (AD) that contributes to cognitive deficits and neuroinflammation. Here we found that RTP801 interacts ...
The aorta is the main artery of the body, whose function is to collect the blood ejected by the heart and distribute it to all tissues. The elastic degree of the aortic wall necessary to withstand blood pressure is mainly ...
