Departament de Biomedicina: Enviaments recents
Ara mostrant els elements 1-20 de 37
RTP801: a novel regulator of the tRNA ligase complex in Alzheimer's disease
[eng] RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer’s disease (AD) that contributes to cognitive deficits and neuroinflammation. Here we found that RTP801 interacts ...
Inhibition of KRAS oncogenic activity by interfering with new KRAS interactors
[eng] INTRODUCTION: The Kirsten rat sarcoma oncogene (KRAS) homologue stands out as a prominent oncogene, distinguished by its notably elevated mutation rate compared to other oncogenes. This genetic anomaly is intricately ...
Machine Learning for predicting Immunotherapy response from routine Medical Imaging
[eng] HYPOTHESIS: Precision oncology has revolutionized the landscape of cancer treatment. Emerging therapeu- tic approaches, such as immunotherapy or anti-angiogenic agents, have exhibited remarkable outcomes in solid ...
Regulación de la separasa mediada por el nuevo papel de Sak1 en mitosis
[spa] El ciclo celular es un conjunto ordenado de sucesos que tienen como fin el crecimiento de una célula y su división en dos células hijas. Uno de los sucesos más relevantes en el ciclo celular es la correcta segregación ...
Molecular contents and functional characterization of extracellular vesicles in plasma of Alzheimer’s disease patients: analysis in response to the AMBAR treatment
[eng] The hypothesis underlying the AMBAR study research seeks to evaluate the clinical efficacy of PE, in combination with albumin and intravenous immunoglobulin replacement (IVIG), as a treatment for Alzheimer's disease ...
Role of polyreactive autoantibodies in the physiopathology of Sjögren’s Syndrome
[eng] Sjögren's syndrome (SjS) is a chronic autoimmune disease that mainly affects the exocrine glands and is characterized by the presence of antinuclear antibodies such as anti-Ro52 and anti-dsDNA. Our previous analysis ...
Evaluación funcional del péptido EAR-20 como posible agonista de los receptores ionotrópicos de glutamato de tipo NMDA
[spa] Debido a la importancia de la modulación del NMDAR, en el grupo de investigación de proteínas (GRIP) se han diseñado una serie de péptidos derivados de la Conantokina-G (Con-G), un péptido antagonista de los NMDARs, ...
Noves estratègies terapèutiques contra la resposta a l’estrès replicatiu en el càncer colorectal
[cat] El nostre laboratori està centrat en l’estudi de la resposta a l’estrès replicatiu, ja que aquest estrès està relacionat amb la tumorigènesi i la seva resposta és un mecanisme fonamental per preservar l’estabilitat ...
Comparative study of nanocarriers targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes
[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised by deficiency of ...
Mitochondrial dynamics and quality control mechanisms in Huntington's disease
[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La característica ...
New insights into ionotropic glutamate receptors in physiological and pathological conditions
[eng] Speaking metaphorically, the human nervous system is a complex ensemble of millions of parts operating together one with another. For this reason, each part is fundamental for the correct function of the whole system. ...
Mecanismes neuronals de la picor aguda i crònica en neurones sensorials: implicació del canal TRESK
[cat] TRESK (K2P18.1) és un canal de potassi de fuga que s’expressa en algunes subpoblacions de neurones sensorials, on modula el potencial de membrana en repòs, la descàrrega de potencial d’acció i l’excitabilitat neuronal. ...
Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells
[eng] Albumin exerts pleiotropic actions beyond its oncotic power, which include binding, transport and detoxification of endogenous and exogenous molecules, antioxidant activity and the modulation of immune and inflammatory ...
Cholesterol and StARD1: a common nexus in Alcoholic Liver Injury and Niemann-Pick Type C disease-associated mitochondrial stress
[eng] Cholesterol accumulation in mitochondrial membranes is a common feature of various chronic diseases, such as cardiovascular disease, cancer, and Alzheimer's as well as liver diseases. Studies prior to this doctoral ...
Microphthalmia-associated Transcription Factor function and regulation in KIT oncogenic pathologies
[eng] KIT (CD117) is a tyrosine kinase receptor expressed in hematopoietic progenitors, melanocytes, germ cells, mast cells, and interstitial cells of Cajal (ICC) of the digestive tract. KIT gain-of-function mutations have ...
Aberrant TIMP-1 regulation in tumor-associated fibroblasts by the TGF-β1/SMAD3 pathway in lung cancer: implications in tumor progression and resistance to antifibrotic therapies
Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression is poorly defined. ...
Regulation of synthesis, transport and accumulation of lipids in Lipid droplets by Acetyl-CoA carboxylase and Caveolins. How cells accumulate lipids but reduce lipotoxicity
The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During the last years, the ...
El paper de p27 a la regulació de la via de Notch
Partint dels resultats previs obtinguts per aquest grup d’investigació, es planteja la següent hipòtesi de treball: “La proteïna p27 és un regulador de la via de Notch. Aquesta regulació es realitzaria, principalment, ...
Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington’s Disease
Huntington’s Disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is caused by an unstable expansion of the CAG trinucleotide ...
Regulació i funció en resposta a diferents tipus d’estrès de la CaMKK Ckk2
Les proteïnes de la família de les CaM quinases (CAMK en anglès), l’activitat de les quals és dependent del complex calci-calmodulina, estan implicada en funcions cel·lulars com la regulació de l’expressió gènica, la ...
