Now showing items 132-151 of 308

    Galenic development of a new sunscreen product for skin cancer prevention 

    Amorós-Galicia, Lola (Date of defense: 2023-02-08)

    [eng] Sunscreen application is one of the best methods to prevent erythema, keratogenic cancer, melanoma and premature skin ageing. UV filters are the active substances preventing the harmful effects. Commercial UV filters ...

    Genetics of natural variation and environmental modulation of immune-related hybrid incompatibilities in Arabidopsis 

    Atanasov, Kostadin Evgeniev (Date of defense: 2019-05-14)

    Arabidopsis thaliana is a small ruderal weed with prominent north-hemisphere distribution. It has an autogamous style of reproduction, whereas about 3% of the natural population can exhibit outcrosses. Some of these ...

    Glycogen regulates cellular proliferation in the context of aging, tumorigenesis, and hepatic regeneration 

    Zapata Garin, Claire-Alix (Date of defense: 2018-06-01)

    Glycogen is a branched polysaccharide that serves as an intracellular store of glucose that can be mobilized to maintain homeostasis or to fuel cellular processes. Glycogen is synthesized by glycogen synthase, which is ...

    Gαq regulates mitochondrial motility and interacts with ALEX3, MIRO1 and TRAK proteins 

    Izquierdo Villalba, Ismael (Date of defense: 2020-01-17)

    G proteins transduce a myriad of signals from receptors at the plasma membrane. Recent reports point to a novel localization of G proteins at the mitochondria and other endomembranes where they regulate the physiology of ...

    Health-promoting phenolic compounds in extra virgin olive oil: an integrated study of their concentration and bioavailability 

    López Yerena, Anallely (Date of defense: 2021-09-28)

    The health promoting attributes associated with following a traditional Mediterranean diet have been reviewed extensively. The principal source of dietary fat in the Mediterranean diet is Extra virgin olive oil (EVOO) that ...

    Heterogeneity of carcinoma-associated fibroblasts and REV-ERB-induced phenotype molding in pancreatic ductal adenocarcinoma 

    Albert Colomer, Nerea (Date of defense: 2021-01-18)

    Tumor-stroma crosstalk is essential for PDAC formation. Therefore, the stroma, and specifically the carcinoma-associated fibroblasts (CAFs), are the target of therapeutic alternatives to treat highly desmoplastic tumors ...

    Human Primary Organoid-Derived Epithelial Monolayers as a Novel Strategy for the Study of Adherent Invasive Escherichia coli pathogenicity and the effects of Postbiotics on Intestinal Epithelial Function 

    Mayorgas, Aida (Date of defense: 2021-09-08)

    Inflammatory bowel disorders – such as Inflammatory Bowel Disease (IBD) – are rising worldwide. A well-known feature of IBD is dysbiosis of the gut microbiota, characterized by a significant reduction of beneficial strains ...

    Identificación y caracterización de nuevos defectos del metabolismo energético mitocondrial asociados a aciduria 3-metilglutacónica y a deficiencia del complejo I 

    Ugarteburu López, Olatz (Date of defense: 2021-09-30)

    Las enfermedades del metabolismo energético mitocondrial son un grupo de patologías con una gran heterogeneidad clínica, bioquímica y genética. Aunque en la última década la implementación de las técnicas de “Next generation ...

    Identification and characterisation of transcriptional regulators through proximity interaction mapping in two distinct systems 

    Lewis, Michael (Date of defense: 2022-11-11)

    [eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different transcriptional ...

    Identification of oxidative stress susceptibility-related genes in cystic fibrosis airway epithelial cells through functional genomics using a randomized siRNA library 

    Checa Raya, Javier (Date of defense: 2021-03-26)

    INTRODUCTION: Pulmonary manifestations are the main cause of morbidity and mortality in more than 90 % of cystic fibrosis (CF) patients who exceed the neonatal period. The chronic immune-inflammatory process, exacerbated ...

    Identification of the interaction networks of Mitofusin-1 and Mitofusin-2 = Identificació de les xarxes d’interacció de Mitofusina-1 i Mitofusina-2 

    Gordaliza Alaguero, Isabel (Date of defense: 2021-11-29)

    Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, cell cycle progression, ...

    Identifying molecular mechanisms that determine resistance to CDK4/6 inhibitors in HER2-enriched advanced luminal breast cancer 

    Gregorio Jordán, Sara (Date of defense: 2021-12-03)

    Breast Cancer (BCa) is the most prevalent cancer among women worldwide. It is a very heterogeneous disease at the histological, molecular and clinical level. Consequently, different classifications are used for stratifying ...

    Identifying new targets to inhibit brat tumour growth in Drosophila melanogaster through combined transcriptomics and functional genome-wide analysis 

    Méndiz Manero, Mª Victoria (Date of defense: 2022-09-16)

    [eng] I have used the brain tumours that originate in Drosophila larvae upon depletion of the brain tumor (brat) gene as a model to study neoplastic malignant growth. I have used genetic analysis to interrogate the Drosophila ...

    Immunoreceptor MerTK: A journey from the membrane into the nucleus of human dendritic cells 

    Borgman, Kyra J. E. (Date of defense: 2018-10-26)

    Discrimination between foreign and potentially harmful antigens, and the body’s own tissue is one of the most crucial first steps that lays at the basis of a proper immune response. Immunoreceptors are cell membrane embedded ...

    The impact of nutrients on clock genes and metabolism: their role for the prevention and treatment of metabolic diseases 

    Castillo Figueroa, Ana Lucía (Date of defense: 2017-04-24)

    A number of recent studies in animals and humans have linked energy regulation and the circadian clock at the molecular, physiological and behavioral levels, concluding that disruption of clock genes results in metabolic ...

    Impacto de los factores de riesgo cardiovascular en las células madre de tejido adiposo 

    Béjar Serrano, María Teresa (Date of defense: 2016-12-19)

    Las enfermedades cardiovasculares se desarrollan como consecuencia de la interacción entre factores genéticos y ambientales. Los factores de riesgo cardiovascular son una serie de condiciones que favorecen la aparición de ...

    Improved Preparative Chemical Methodologies to Address Challenging Targets: Synthetic, Semi-synthetic and Multicomponent Approaches 

    Pedrola Teixell, Marina (Date of defense: 2022-07-14)

    In the context of facilitated methodologies for the obtention of bioactive compounds, in this thesis we have explored the possibility of introducing reliable, pot-economic and semi-synthetic approaches in the quest of ...

    Improving islet-graft revascularization 

    Alves Figueiredo, Hugo Jorge (Date of defense: 2018-06-29)

    El trasplante de islotes ha sido reconocido como una prometedora opción de tratamiento de la diabetes tipo 1 (DT1) tras la introducción del protocolo de Edmonton, el cual enfatiza el requerimiento de un adecuado número de ...

    In silico molecular modelling and design of heme-containing peroxidases for industrial applications 

    Cañellas Fontanilles, Marina (Date of defense: 2018-07-17)

    It is widely known that the development of modern chemistry and the consequent world industrialization have improved our quality of life to unimaginable levels. However, these advances have come with a high cost, causing ...

    Influencia de la educación nutricional, hábitos de estilo de vida obesogénicos y predictores de pérdida de peso en pacientes con obesidad grave incluidos en un programa de cirugía bariatrica 

    Parri Bonet, Alejandra (Date of defense: 2019-11-13)

    INTRODUCCIÓN: La obesidad grave es una enfermedad crónica que se caracteriza por un exceso de grasa corporal, que condiciona un aumento de la morbimortalidad. La cirugía bariátrica es el tratamiento de elección cuando ha ...