Universitat de Barcelona
Now showing items 270-289 of 308
The mitochondrial transcription factor A, TFAM, has a dual function in the organelle: it activates mitochondrial DNA transcription by binding to the HSP and LSP promoters, while in higher concentrations compacts the mtDNA. ...
[eng] The emergence and spread of antibiotic resistance among bacteria has become an undisputed global problem and one of the greatest threats to public health in the 21st century. The widespread, excessive and uncontrolled ...
The common scope of this thesis is the application of structural biology and biophysics to obtain novel data on nuclear proteins that modulate DNA transcription. The proper regulation and functioning of these elements are ...
The herpesvirus diseases are increasing in importance as a public health problem throughout the world. Members of the human herpesvirus family are global in distribution and infect 60-95% of the world's population, both ...
[eng] G-quadruplexes are non-canonical DNA structures that appear in Guanine-rich oligonucleotides. Four Guanines interact through Hoogsteen hydrogen bonds forming a tetrad which is stabilized by metallic ions. Two or more ...
Adult zebrafish (Danio rerio), in contrast to mammals, are able to regenerate their hearts in response to injury or experimental amputation. Our understanding of the cellular and molecular bases that underlie this process, ...
The calcineurin inhibitor Tacrolimus (Tac) is used to prevent acute rejection after renal transplant. Unfortunately, the clinical use of Tac is complicated by its considerable toxicity, narrow therapeutic window, and high ...
Venous Thrombosis (VT) is a frequent complex disease that involves a disruption of the balance of the hemostatic system. microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Promising findings in ...
Hasta hace no muchos años la obesidad se relacionaba con un desequilibrio entre la ingesta dietética y el gasto energético. Sin embargo, esta aproximación era muy simplista y actualmente se conoce el carácter multifactorial ...
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems biology and biophysical ...
The present Thesis is divided in three chapters: 1. Design and synthesis of new soluble epoxide hydrolase inhibitors (sEHI) The synthesis of new soluble epoxide hydrolase inhibitors based on ureas as the main ...
[eng] My thesis was part of a collaborative project at the interface of neuropharmacology and medicinal chemistry that aimed to better understand the neuromodulation mechanisms associated with Alzheimer’s Disease (AD). In ...
Over the past decade, sphingolipids have emerged as a new class of modulators of various cell functions. Ceramide, which is the central molecule in the biosynthesis of sphingolipids and glycosphingolipids, is involved in ...
[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are very old, therefore ...
En Ia levadura de gemación el tamaño celular en START o tamaño crítico está determinado por Ia velocidad de crecimiento en G1. Durante esta fase, Saccharomyces cerevisiae presenta una disminución de Ia relación ...
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α inhibitors are mainly ...
[eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is insufficient to ...
La malaria es una enfermedad infecciosa producida por Plasmodium, protozoo transmitido a través de la picadura de mosquitos del género Anopheles. Aunque existen tratamientos y medidas de prevención, en los países tropicales ...
[eng] Advances in structural and molecular biology have favoured the rational development of novel drugs thru structure-based drug design (SBDD). Particularly, computational tools have proven to be rapid and efficient tools ...
The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded in vitro reconstitution ...
