Aledavood, Elnaz (Date of defense: 2021-10-01)
This doctoral thesis is focused on disclosing molecular factors that regulate the functional mechanism of key targets in i) metabolic disorders, such as diabetes and obesity, and ii) tuberculosis (TB). ...
Villamor Payà, Marina (Date of defense: 2021-07-08)
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute ...
Vilaplana Saiz, Marta (Date of defense: 2021-01-22)
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major ...
Ugarteburu López, Olatz (Date of defense: 2021-09-30)
Las enfermedades del metabolismo energético mitocondrial son un grupo de patologías con una gran heterogeneidad clínica, bioquímica y genética. Aunque en la última década la implementación de las técnicas ...
González Velasco, Lorena (Date of defense: 2021-09-14)
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α ...
Carvajal Vidal, Paulina Andrea (Date of defense: 2021-02-19)
Existe una amplia variedad de alternativas terapéuticas para el tratamiento de las enfermedades inflamatorias dérmicas que permiten una aproximación local o sistémica dependiendo de la severidad de los ...
Zimmermann, Fabian (Date of defense: 2021-11-24)
The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded ...
Benítez, Sandra (Date of defense: 2021-01-13)
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive ...
Mayorgas, Aida (Date of defense: 2021-09-08)
Inflammatory bowel disorders – such as Inflammatory Bowel Disease (IBD) – are rising worldwide. A well-known feature of IBD is dysbiosis of the gut microbiota, characterized by a significant reduction ...
Merino Méndez, Raquel (Date of defense: 2021-12-13)
OBJETIVOS: Describir y analizar la prevalencia de la polimedicación y de la prescripción “off-label” de los pacientes con daño cerebral adquirido (DC) y con lesión medular (LM) que estaban ingresados ...