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Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions

Now showing items 61-80 of 331

    Mecanismos de resistencia a terapias dirigidas contra BRAF(V600E) y estudio de nuevas combinaciones de fármacos en cáncer de colon 

    Ramírez Corpas, Lorena (Date of defense: 2023-01-20)

    [spa] Alrededor del 10% de los pacientes con cáncer colorrectal metastático (mCRC) presentan la mutación BRAF(V600E), mutación que está asociada a una peor respuesta al tratamiento estándar con agentes quimioterapéuticos ...

    Technological developments in Virtual Screening for the discovery of small molecules with novel mechanisms of action 

    Miñarro Lleonar, Marina (Date of defense: 2023-02-24)

    [eng] Advances in structural and molecular biology have favoured the rational development of novel drugs thru structure-based drug design (SBDD). Particularly, computational tools have proven to be rapid and efficient tools ...

    Child behavior, feeding practices, and health in the context of obesity 

    Juton, Charlotte (Date of defense: 2023-03-09)

    [eng] Childhood obesity is a global public health problem with aggravating consequences during adulthood, including cardiovascular disease, type 2 diabetes, musculoskeletal disorders, and some types of cancers. The reason ...

    Fatty acids and antioxidants in older adults with visual impairment: A contribution to Healthy Ageing 

    Caballero Arredondo, Mariana (Date of defense: 2023-01-24)

    [eng] This research aims to study the effect of supplementation with docosahexaenoic acid (DHA) and antioxidants in older adults diagnosed with age-related macular degeneration or cataracts to contribute to preventive ...

    Development and characterization of solid lipid nanoparticles (SLN) as a vehicle of biomolecules 

    Bustos Araya, Marta Eduviges (Date of defense: 2023-02-24)

    [eng] The interest of this work was to manufacture solid lipid nanoparticles that serve as a vehicle for biomolecules, specifically Chondroitin sulfate and pEGFP plasmid DNA. In the experimental part, the reagents and ...

    Unraveling the Fundamental Aspects of Enzyme-powered Micromotors 

    Arqué Roca, Francesc Xavier (Date of defense: 2023-01-24)

    [eng] Enzyme-powered motors are based on the micro- and nanosized particles that propel thanks to the chemical conversion of enzymes attached on their surface. Recently, these tiny devices have been applied for a plethora ...

    Galenic development of a new sunscreen product for skin cancer prevention 

    Amorós-Galicia, Lola (Date of defense: 2023-02-08)

    [eng] Sunscreen application is one of the best methods to prevent erythema, keratogenic cancer, melanoma and premature skin ageing. UV filters are the active substances preventing the harmful effects. Commercial UV filters ...

    Discovery of First-In-Class inhibitors of a DNA damage repair pathway 

    Camps i Fajol, Cristina (Date of defense: 2022-12-19)

    [eng] Cancer is the second leading cause of death globally. The gold standard for cancer has historically been surgery, radiotherapy and chemotherapy. Although the efficacy of chemotherapy has been broadly confirmed, drug ...

    Efecto de la Dieta Mediterránea sobre los patones de tratamiento farmacológico en adultos con alto riesgo cardiovascular 

    Ribó-Coll, Margarita (Date of defense: 2022-12-16)

    [spa] Las enfermedades cardiovasculares (ECV), representan la principal causa de morbimortalidad en los países desarrollados y su aumento continúa a nivel mundial. Su denominación hace referencia a varias enfermedades de ...

    BasC K154 role on cytosolic gate closing. The bacterial alanine-serine-cysteine transporter as a model 

    Nicolàs i Aragó, Adrià (Date of defense: 2022-12-14)

    [eng] L-type amino acid transporters play key roles in human physiology and are involved in several human pathologies such as primary inherited aminoacidurias (Feliubadaló et al., 1999; Torrents et al., 1999), autism ...

    Determinants de pèrdua de pes en persones amb obesitat intervingudes amb tècniques bariàtriques endoscòpiques. Desenvolupament i validació d’un nou qüestionari curt d’hàbits saludables d’alimentació i d’activitat física 

    Miranda Peñarroya, Maria Gemma (Date of defense: 2022-11-28)

    [cat] Les teràpies endoscòpiques bariàtriques (TEB) són estratègies prometedores per al tractament de l'obesitat. No obstant això, hi ha una gran variabilitat en la pèrdua de pes i els individus sovint recuperen el pes ...

    Identification and characterisation of transcriptional regulators through proximity interaction mapping in two distinct systems 

    Lewis, Michael (Date of defense: 2022-11-11)

    [eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different transcriptional ...

    Dietary (poly)phenols intake and cardiometabolic health in adolescents from Spain 

    Laveriano Santos, Emily Pilar (Date of defense: 2022-11-29)

    [eng] The rising of cardiometabolic risk factors like obesity, higher blood pressure, and alteration in the metabolism of lipids and glucose during adolescence increase the risk of type 2 diabetes mellitus and cardiovascular ...

    Desarrollo de sistemas nanoestructurados conteniendo Lactoferrina para el tratamiento de patologías oculares 

    López Machado, Ana Laura (Date of defense: 2022-11-04)

    [spa] La inflamación ocular es uno de los trastornos oftalmológicos más comunes y está asociada a un amplio abanico de patologías que afectan tanto al segmento anterior como posterior del ojo. El síndrome del ojo seco (SOS) ...

    Effect of Cpt1a deletion in the mediobasal hypothalamus in response to physical activity and aging 

    Ibeas Martínez, Kevin (Date of defense: 2022-11-04)

    [eng] Food intake and energy homeostasis are tightly regulated by the brain through a complex neuronal network located in the hypothalamus. Within this region, the mediobasal hypothalamus (MBH) acts as an interface between ...

    Unveiling the therapeutic potential of THC in endometrial cancer 

    Coll Iglesias, Laura (Date of defense: 2022-11-23)

    [eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported autophagy pathway ...

    CPT1AM overexpression in BAT from HFD-treated mice prevents the induction of obesity and associated diabetes 

    Bastías Pérez, Marianela Pía (Date of defense: 2022-11-21)

    [eng] Obesity and its associated metabolic diseases are currently a priority research topic. The increase in global prevalence at different ages is having a huge economic and health impact. Genetic and environmental factors ...

    Development and application of in-vitro assays for the study of the biological activity of pharmaceutical products 

    Cañellas Santos, Mariona (Date of defense: 2022-11-03)

    [eng] This industrial Ph.D. thesis aimed to illustrate the presence of the cell-based bioassays throughout the whole life of a drug product and to demonstrate its importance for a complete characterization of a pharmaceutical ...

    Targeting Plasmodium falciparum protein aggregation as a new antimalarial design strategy 

    Bouzón Arnáiz, Inés (Date of defense: 2022-11-11)

    [eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is insufficient to ...

    Nutritional management of Myotonic Dystrophy type 1 

    Pascual Gilabert, Marta (Date of defense: 2022-11-04)

    [eng] Myotonic dystrophy type 1 (DM1), one of the more complex diseases already known, is the most common and multisystemic rare neuromuscular disease among adults, without cure and limited pharmacological treatments. In ...