Facultat de Farmàcia i Ciències de l'Alimentació: Envíos recientes
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Synthesis and development of bioactive compounds: soluble epoxide hydrolase inhibitors and antiviral molecules
The present Thesis is divided in three chapters: 1. Design and synthesis of new soluble epoxide hydrolase inhibitors (sEHI) The synthesis of new soluble epoxide hydrolase inhibitors based on ureas as the main ...
The Tousled-like kinases and their implications in cancer and neurodevelopmental disorders
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute to histone deposition ...
Identificación y caracterización de nuevos defectos del metabolismo energético mitocondrial asociados a aciduria 3-metilglutacónica y a deficiencia del complejo I
Las enfermedades del metabolismo energético mitocondrial son un grupo de patologías con una gran heterogeneidad clínica, bioquímica y genética. Aunque en la última década la implementación de las técnicas de “Next generation ...
Colloidal lipid gels: A novel approach to structure dispersions of lipids
Lipids are essential components in most living organisms whose functionality varies with their chemical structure. In an aqueous environment, diluted dispersions of phospholipids tend to form vesicles and other bilayered ...
Tris(triphenylphosphine)Ruthenium(II) dichloride: a versatile catalystin the synthesis of β-, γ- and δ-lactams from trichloroacetamides and in the isomerization of protected allylamines to Z-enamines under microwave activation
In this PhD thesis we have demonstrated that tris(triphenylphosphine)ruthenium(II) dichloride (RuCl2(PPh3)3) is a potent and versatile catalyst capable of achieving efficient different chemical transformations under microwave ...
Utilización de aceites ácidos y ácidos grasos destilados en alimentación animal: caracterización de estos subproductos y repercusiones de su uso en la estabilidad oxidativa de piensos y carne de pollo
La correcta formulación de piensos es esencial para conseguir dietas que aporten al animal niveles equilibrados de nutrientes, a la vez que se consiga una eficiencia en la producción animal mediante piensos con palatabilidad ...
Functional analysis of a phloem cysteine protease in Arabidopsis thaliana
Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite diverse, from ...
Population pharmacokinetic-pharmacodynamic modeling in solid organ transplantation: Basis of personalized immunosuppression
Despite advances in immunosuppression, allograft rejection and clinical outcomes remain a challenge in solid organ transplantation. Currently, the immunosuppressive treatment’s individual adjustment is guided by the ...
Nanotechnology-mediated strategies targeting cancer stem cells for advanced cancer treatment
Despite the latest advances in early diagnosis and increased resources employed to develop new therapeutic options, effective control of cancer disease remains a challenge. In fact, cancer is the second leading cause of ...
Polimedicación y Prescripción “off-label” del Paciente con Daño Cerebral Adquirido y Lesión Medular
OBJETIVOS: Describir y analizar la prevalencia de la polimedicación y de la prescripción “off-label” de los pacientes con daño cerebral adquirido (DC) y con lesión medular (LM) que estaban ingresados en un hospital de ...
Metal-dependent 2-oxoacid aldolases as versatile biocatalysts for the synthesis of chiral multifunctional compounds
Biocatalysis gained importance in the latter half of the 20th century and its application in the pharmaceutical, food and chemical industries continues to expand nowadays. Enzymes catalyze chemical reactions in a highly ...
Targeting non-canonical p38 MAPK signalling: discovery and characterization of novel allosteric p38α inhibitors
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α inhibitors are mainly ...
Health-promoting phenolic compounds in extra virgin olive oil: an integrated study of their concentration and bioavailability
The health promoting attributes associated with following a traditional Mediterranean diet have been reviewed extensively. The principal source of dietary fat in the Mediterranean diet is Extra virgin olive oil (EVOO) that ...
Structural and Functional Analysis of the Glucocorticoid Receptor Multimerization: Implications for Human Pathophysiology
El receptor de glucocorticoides (GR) es un factor de transcripción que se expresa de forma ubicua y controla procesos esenciales para la vida como el metabolismo, la inflamación y la homeostasis. Aunque se han publicado ...
Electrochemical immunosensors for pesticide residue detection in food matrices
This thesis has been developed in the framework of the European FoodSmartphone project with the objective to develop user-friendly smartphone-connected electrochemical immunosensors for pesticide residue detection in ...
Spinal Biomechanical Alterations, Neurogenic Inflammation (CGRP), Dermatitis
Dermatitis is a chronic inflammatory skin disease, described by intensive pruritus and eczematous lesions of skin. In most of the patients with Dermatitis, a long-lasting cycle of itch-scratch roots produces substantial ...
Identifying molecular mechanisms that determine resistance to CDK4/6 inhibitors in HER2-enriched advanced luminal breast cancer
Breast Cancer (BCa) is the most prevalent cancer among women worldwide. It is a very heterogeneous disease at the histological, molecular and clinical level. Consequently, different classifications are used for stratifying ...
Identification of the interaction networks of Mitofusin-1 and Mitofusin-2 = Identificació de les xarxes d’interacció de Mitofusina-1 i Mitofusina-2
Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, cell cycle progression, ...
Development and characterization of in vivo models for Photopharmacology
The main aim of this thesis is setting up and using in vivo screening techniques to identify and characterize new photopharmacological compounds targeting endogenous proteins. In order to achieve that aim, the thesis ...
Monocapes autoassemblades electroactives: interaccions π-donador/π-acceptor per a induir transport en superfície
Les proteïnes motores s’encarreguen del transport intracel·lular de cargoes a través de fibres tubulars presents en el citosquelet mitjançant la hidròlisis del trifosfat d'adenosina (ATP) com a força motriu del moviment. ...
