Browsing Facultat de Medicina i Ciències de la Salut by Subject "616"

A Cancer Prevention Dendritic Cell Vaccine: Frameshift-Derived Neoantigens as Immunopreventive Targets in Lynch Syndrome

Bayó Llorens, Cristina (Date of defense: 2025-06-13)

[eng] Lynch Syndrome (LS) is the most common cause of hereditary colorectal cancer and is associated with pathogenic germline variants in DNA mismatch repair (MMR) genes. The deficiency in this repair system leads to an ...

A gendered approach to cancer control: Leveraging implementation science and systems thinking for health equity

Mallafré-Larrosa, Meritxell (Date of defense: 2025-07-10)

[eng] INTRODUCTION: Cancer is a leading global health and development challenge, responsible for nearly 10 million deaths annually. Despite advancements in prevention, early detection, and treatment, cancer-related health ...

A long-lasting porcine model of ARDS caused by Pseudomonas aeruginosa and Ventilator-Induced Lung Injury

Arrieta Ruiz, Marta (Date of defense: 2025-04-03)

[eng] INTRODUCTION: Existing animal models of acute respiratory distress syndrome (ARDS) are varied and often differ compared to human ARDS in their main features of lung damage, etiology, pathophysiology, or maintenance ...

Abordatge endoscòpic multidisciplinari de tumors subepitelials gastrointestinals de petita mida: lligadura amb banda sense resecció i ansietat-carcinofòbia

Bas Cutrina, Francesc (Date of defense: 2023-09-14)

[cat] INTRODUCCIÓ: Els tumors subepitelials gastrointestinals (TSE-GI) inespecífics de petita mida requereixen d’un control periòdic endoscòpic degut al risc que es tractin d’entitats amb potencial de malignització. Malgrat ...

Actividad terapéutica y beneficio a largo plazo de la ablación percutánea con radiofrecuencia y/o microondas en pacientes con carcinoma hepatocelular

Muñoz Martínez, Sergio Gabriel (Date of defense: 2024-09-05)

[spa] El cáncer hepático es el sexto tipo de cáncer más común a nivel mundial, es la tercera causa de mortalidad relacionada a cáncer y se prevee que aumente su incidencia global para el año 2040]. El carcinoma hepatocelular ...

Advancing in Endometrial Cancer Prevention: Exploring the Role of Circadian Disruption Factors and the Sensitivity of Cervicovaginal Cytology for its Detection

Frias Gomez, Jon (Date of defense: 2024-11-22)

[eng] INTRODUCTION: Endometrial cancer (EC) is the most common gynecological tumor in developed countries, with an increasing incidence due to population aging and growing obesity. This cancer is estrogen-dependent, so ...

Advancing precision medicine in cancer and COVID-19 with bioinformatics: a multifaceted affair

García Prieto, Carlos Antonio (Date of defense: 2024-12-14)

[eng] Advancing precision medicine requires integrating bioinformatics to unravel complex biological data and translate these insights into clinical applications. This thesis explores the role of bioinformatics in enhancing ...

Alterations in the masticatory system in patients with amyotrophic lateral sclerosis and its management with an oral appliance

Riera-Punet, Nina (Date of defense: 2019-03-01)

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive degeneration of the lower (LMN) and upper motor neurons (UMN) in the spinal cord and brain, causing muscle ...

An epigenetic approach for Ewing sarcoma patients

Sánchez Jiménez, María (Date of defense: 2024-12-03)

[eng] CHAPTER 1: Ewing sarcoma (EwS) is the most common malignant neoplasm in bone and soft tissues among adolescents and young adults in Spain, characterized by a chromosomal translocation between an ETS factor and a ...

Analysis of KRAS phosphorylation and KRAS effector domain as targets for cancer therapy

Cabot, Débora (Date of defense: 2020-09-28)

[eng] Analysis of KRAS phosphorylation and KRAS effector domain as targets for cancer therapy Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer (CRC). It has been suggested ...

Analysis of multidisciplinary clinical practice in cancer care and factors related to the professional roles of the care teams: A qualitative and quantitative evaluation in the framework of the Catalan Health System

Rivera Villalobos, Darinka (Date of defense: 2024-11-14)

[eng] INTRODUCTION: The last 20 years have seen significant progress in cancer control, driven by multiple advances in different areas such as technology, surgery procedures, medical treatments, but also by innovation in ...

Anàlisi translacional de la teràpia fotodinàmica mitjançant l’àcid 5-aminolevulínic en el tractament del Glioblastoma

Ferrés Pijoan, Abel (Date of defense: 2024-10-04)

[cat] INTRODUCCIÓ: El Glioblastoma (GB) IDH-wild type (“World Health Organization Classification of Tumors of the Central Nervous System 2021”) continua essent el tumor cerebral primari més freqüent i letal en adults tot ...

Análisis de los resultados de los medicamentos en situaciones especiales en una institución monográfica de cáncer

Fontanals Martínez, Sandra (Date of defense: 2024-01-12)

[spa] INTRODUCCIÓN: La innovación e investigación en cáncer son muy activas y la incorporación de nuevos medicamentos al arsenal terapéutico oncológico implica un proceso regulatorio y de posicionamiento complejo, que ...

Análisis molecular de los ganglios linfáticos en carcinoma colorectal precoz

Rodrigo Calvo, María Teresa (Date of defense: 2024-06-10)

[spa] HIPÓTESIS: La hipótesis de la presente tesis doctoral se basa en que la utilización del método OSNA para el análisis de ganglios linfáticos en etapas muy tempranas de carcinomas colorrectales, pTis y pT1, ...

Androgen receptor modulation: A tailored approach for oestrogen receptor-positive metastatic breast cancer

Monserrat Vicente, Laia (Date of defense: 2024-01-12)

[eng] Breast cancer (BC) is the most diagnosed cancer in women and the second leading cause of cancer-related deaths in this population. Luminal BC accounts for 70% of tumours and is characterised by the expression of ...

Anti-inflammatory effects of Human Serum Albumin and its mechanism of action in decompensated cirrhosis

Casulleras i Oliver, Mireia (Date of defense: 2022-07-15)

[eng] This doctoral thesis is divided in two studies with the commune aim of elucidating the molecular mechanisms of albumin on leukocytes, in the context of advanced liver cirrhosis. The first study is focused in the ...

Anticoagulación con citrato diluido y concentrado en la terapia depurativa renal continua

Mateos Dávila, Mª Almudena (Date of defense: 2023-11-22)

[spa] INTRODUCCIÓN: El paciente grave con fracaso renal agudo (FRA) que necesita una terapia continua de reemplazo renal (TCRR) tiene muchos riesgos asociados. La coagulación de los circuitos que se utilizan en estos ...

Aplicabilidad clínica de la caracterización molecular sobre biopsias endoscópicas de cáncer gástrico

Serra Solé, Òlbia (Date of defense: 2024-10-02)

[spa] JUSTIFICACIÓN DE LA TESIS: Ninguna de las clasificaciones para CG “clásicas”, histopatológicas, utilizadas hasta el momento ha demostrado tener utilidad en la selección del mejor tratamiento para el paciente. La ...

Aplicación del Índice de Desaturación-Distancia (DDR) en pacientes con Hipertensión Arterial Pulmonar (HAP): Seguimiento y Pronóstico de Supervivencia

Alsina Restoy, Javier (Date of defense: 2025-04-11)

[spa] INTRODUCCIÓN: En la introducción, se aborda una revisión exhaustiva sobre la prevalencia, la etiopatogenia, el diagnóstico y el tratamiento de una de las enfermedades respiratorias crónicas más importantes en el ...

ARNs no codificantes como biomarcadores predictivos y pronósticos de la quimio-radioterapia neoadyuvante en cáncer de recto

Benítez Montañez, José Carlos (Date of defense: 2024-03-14)

[spa] INTRODUCCIÓN: El cáncer colorrectal es uno de los tumores más frecuentes en ambos sexos. En este contexto, es de especial interés el estudio del cáncer de recto, cuyo tratamiento principal cuando no es metastásico ...

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