Facultat de Medicina i Ciències de la Salut: Envíos recientes
Mostrando ítems 21-40 de 544
Sleep disorders in immune-mediated synaptic encephalopathies
[eng] INTRODUCTION: Autoimmune encephalitis (AEI) is an inflammatory disease of the central nervous system, caused by specific antibodies against synaptic or neural surface proteins. More than twenty have been described ...
Unveiling the role of the Mediator complex in Ewing sarcoma tumorigenesis
[eng] Ewing sarcoma is an aggressive tumor arising in bones and soft tissues that affects children and young adults. This disease is determined by an aberrant chromosomal translocation that forms an oncogenic fusion protein, ...
Eficacia y seguridad de las nuevas técnicas de resección endoscópica para neoplasias precoces gastrointestinales
[spa] INTRODUCCIÓN: La detección y caracterización endoscópica de lesiones neoplásicas precoces (lesiones superficiales confinadas a la mucosa o submucosa que en casos seleccionados tienen un riesgo muy bajo de metástasis ...
IKKα modulates metastatic activity by preventing Tight Junctions stabilization and collective cell migration
[eng] The IKKα kinase was previously found to activate multiple oncogenic and therapy-resistance pathways, including ATM/DDR, BRD4, and JAK/STAT3, independently of canonical NF-KB signaling. Here, we show that suppression ...
New therapeutic approaches to target myofibroblast activation in liver pathologies: fibrosis and cholangiocarcinoma
[eng] HYPOTHESES: Iron accumulation and senescence mediate fibrosis progression in kidney and lung. In the liver, iron overload, specifically in hepatocytes, has been linked to hepatic diseases such as hereditary ...
Diagnóstico de la causa de muerte y caracterización de infecciones fatales en muestras post mortem en países de baja renta
[spa] INTRODUCCIÓN: La ausencia de datos confiables sobre las causas de muerte se ha señalado como un factor limitante para reducir la mortalidad en el mundo. Entendemos que para poder desarrollar un planteamiento y ...
Understanding Adiposity through Body Shape Phenotypes: Implications for Cancer Risk, Inflammation, and Prediction
[eng] INTRODUCTION. Obesity is characterized by excess body fat (adiposity) and is a major determinant of disability. Obesity is mainly measured by body mass index (BMI) although it presents several limitations. For instance, ...
Unraveling the molecular basis of the metastatic process in Ewing sarcoma: insights into the role of LOXHD1 and PARP14
[eng] HYPOTHESIS AND OBJECTIVES 1. Hypothesis: Metastasis is the worst prognostic factor in EwS patients, dropping patients’ overall survival to less than 30 %43. Further, about 25 % of patients present with metastatic ...
Evaluación de factores de riesgo de retrombosis y sangrado en pacientes con enfermedad tromboembólica venosa
[spa] HIPÓTESIS: 1. Establecer las ratios de recurrencia, sangrado mayor, y las tasas de mortalidad tras un primer episodio de trombosis no provocada, puede ayudar en la decisión de mantener o suspender la anticoagulación ...
Brain mechanisms and psychological determinants of mental health resilience. Learning from the COVID-19 pandemic
[eng] When confronted with a stressful situation, our reactions can vary greatly. In general, the population comes across to be resilient, being able to resist or adapt to disturbances. However, this is not the case for ...
Radioterapia estereotáctica en lesiones óseas. Factor tiempo como predictor de supervivencia
[spa] INTRODUCCIÓN: En los últimos años se ha producido una mejora en el pronóstico de los pacientes metastásicos gracias a los avances en terapias oncológicas. Debido a ello, el abordaje radical de las metástasis ha ido ...
Generation of high-performance cellular model for Huntington’s disease
[eng] Huntington’s disease (HD) is an autosomal dominant inherited neurological disease, which is caused by mutation in the HTT gene that encodes for the huntingtin protein. The disease leads to involuntary movements, ...
ZeGRIN: Using zebrafish GRIN-related disorders models for disease understanding and therapeutic discovery
[eng] The glutamatergic neurotransmission system is crucial for brain function, and its dysregulation is involved in several neurological diseases, including developmental, psychiatric and neurodegenerative disorders. ...
Impacto clínico y biológico de los trastornos respiratorios del sueño en la fibrosis pulmonar idiopática
[spa] INTRODUCCIÓN: Los pacientes con fibrosis pulmonar idiopática (FPI) presentan un elevado número de comorbilidades que pueden impactar en su calidad de vida y pronóstico. Entre ellas, los trastornos respiratorios ...
Análisis de los incidentes con múltiples afectados intencionados en el Siglo XXI
[spa] INTRODUCCIÓN: Los incidentes con múltiples afectados intencionados (IMAi), la mayoría clasificados como actos terroristas, son sucesos provocados por uno o más agresores activos con intención de originar el mayor ...
Polycystic ovary syndrome in adolescent girls: treatment oriented to pathophysiology and new markers of effciacy
[eng] Polycystic ovary syndrome (PCOS) could begin with a mismatch between prenatal (reduced) and postnatal (increased) growth, causing an excess of hepato-visceral fat. Dysfunction of adipose tissue, alteration of the ...
Study of biofunctionalized titanium implants on an osteoporotic animal model
[eng] INTRODUCTION: Titanium-based medical devices for bone implantation are currently considered the standard treatment when favorable health, repair and healing conditions are observed. Dental implants, joint prostheses, ...
Análisis de los Factores Virales e Inmunológicos en la Patogénesis y Tratamiento de la Hepatitis Crónica B: Estudio Comparativo Intrahepático y Periférico
[spa] El objetivo fue analizar los factores virológicos, clínicos e inmunológicos tanto en la sangre como en el hígado, en el contexto de la hepatitis crónica B y su relación con la patogénesis de la infección por el VHB ...
Hepatitis B y C en migrantes provenientes de áreas de elevada prevalencia atendidos en Barcelona
[spa] INTRODUCCIÓN: En esta tesis doctoral sobre el estudio de las hepatitis crónicas por el virus de la hepatitis B (VHB) y el virus de la hepatitis C (VHC) en migrantes, nos hemos centrado en los dos países que tienen ...
Dynamic computer-assisted surgery for the placement of dental implants
[eng] INTRODUCTION: Computer-Assisted Surgery (CAIS) in Dentistry has been designed with the purpose of minimizing discrepancies between preoperative planning and the final position of the implant. Dynamic CAIS (dCAIS), ...
