Facultat de Medicina i Ciències de la Salut: Recent submissions
Now showing items 41-60 of 622
Cellular senescence and inflammatory complement system in bone homeostasis
[eng] Bone loss due to chemotherapy or aging depends on cellular senescence and its secretory phenotype. Even so, it is unknown what factors secreted in the senescent environment contribute to bone loss and osteoporosis. ...
La hiposmia y el trastorno de conducta durante el sueño REM idiopático como marcadores prodrómicos de las alfa-sinucleinopatías
[spa] Las alfa-sinucleinopatías, constituidas por la enfermedad de Parkinson (EP), la demencia con cuerpos de Lewy (DCLw) y la atrofia multisistémica (AMS), presentan una fase prodrómica donde pueden estar presentes ...
Linfoma de células grandes B: Caracterización genética y utilidad en el diagnóstico y pronóstico de la biopsia líquida
[spa] El linfoma difuso de células grandes B (LDCGB) es una neoplasia con gran heterogeneidad clínico-biológica y es el síndrome linfoproliferativo más frecuente en el mundo occidental y el paradigma de linfoma agresivo, ...
Utilitat clínica de l’ADN circulant tumoral en pacients amb càncer colorectal
[cat] L’abordatge terapèutic dels pacients amb càncer colorectal (CCR) està definit principalment per la localització tumoral, l’extensió de la malaltia (estadiatge TNM) i el diagnòstic patològic i molecular. Així, en el ...
Oncogenes in aggressive B cell lymphomas: dissecting the mechanisms of their aberrant expression and tumorigenic role
[eng] B cell lymphomas are a heterogeneous group of hematological neoplasms. The first tumorigenic events in B cell lymphomagenesis are usually translocations involving defined oncogenes that often lead a block on normal ...
Beta cell dedifferentiation in the treatment of type 2 diabetes
[eng] Type 2 Diabetes Mellitus (T2DM) is the most common type of diabetes (90-95 %) traditionally associated with peripheral insulin resistance that entails compensatory β- cell mass expansion and hyperinsulinemia during ...
Epigenetic and Epitranscriptomic Changes during Leukemic Cell Transdifferentiation
[eng] Cellular transdifferentiation is defined as the process in which a differentiated cell from one specific lineage directly differentiates into another type of cell from another different lineage without going through ...
Implicació de la proteïna P27 en la regulació de la respiració cel·lular
[cat] La proteïna p27kip1 (p27) va ser inicialment descrita com a reguladora del cicle cel·lular per la seva capacitat d'inhibir gran part dels complexos ciclina-cdk. Tanmateix, evidència científica recent descriu que p27 ...
Study of a custom panel of CXC chemokines in the serum from metastatic CRC patients as predictive and/or prognostic biomarkers
[eng] Worldwide, CRC is the third most common cancer considering both sexes and represents the second most common cause of cancer-related death. CRC patients’ survival is related to the tumor stage at the time of diagnosis. ...
The role of antiphospholipid antibody pattern in the recurrence of thrombosis in patients with Antiphospholipid Syndrome
[eng] Antiphospholipid antibody syndrome (APS) is the most acquired thrombophilia being clinically characterized by vascular thrombosis and morbidity (recurrent miscarriages, fetal death and/or premature birth), associated ...
Multidisciplinary digital tools for improving early diagnosis and treatment of respiratory disease – focus on pulmonary fibrosis
[eng] INTRODUCTION: In this era of powerful cloud computing and data generation, it is important to investigate the benefits we can achieve by leveraging these tools to improve health outcomes. In respiratory medicine, ...
Deciphering the context of cancer cell dependency on p38a MAPK
[eng] Eukaryotic cells rely on the mitogen-activated protein kinase (MAPK) pathways to respond to different stimuli and change their behaviour accordingly. Among the MAPKs, the p38 family is primarily activated by stress ...
The tumor microenvironment in liver metastases from colorectal cancer in the context of histologic growth patterns
[eng] Colorectal cancer (CRC) is the third most frequent cancer type in the world and the second cause of death because of cancer. Nowadays, 25% of cases are diagnosed at the metastatic stage (mCRC), and 20-25% of the ...
Development and Characterization of Bioprintable Physiomimetic Scaffolds for Tissue Engineering
[eng] Tissue engineering is a field of study in which engineers use technology to mimic the structure of human tissue as closely as possible. The development of 3D tissue culture is a major area of research because cells ...
Papel de la corteza infralímbica en el trastorno depresivo mayor: relevancia para nuevas estrategias antidepresivas
[spa] La corteza infralímbica (IL) en roedores es equivalente a la corteza cingulada anterior ventral (CCAv) en humanos, la cual juega un papel clave en la fisiopatologia del trastorno depresivo mayor (TDM). Existe un ...
Estimulació magnètica perifèrica repetitiva per a la valoració de l’espasticitat de canell en pacients post ictus
[cat] ANTECEDENTS: L’escala de valoració de l’espasticitat més utilitzada en la pràctica clínica, l’escala modificada d’Ashworth, presenta problemes per la interpretació correcta del que realment mesura i pel fet que es ...
Pneumònia per COVID-19 i associada a la ventilació mecànica: caracterització de la Síndrome de Distrés Respiratòria Aguda en aquestes dues malalties
[cat] La síndrome de distrés respiratòria aguda és causada per patologies habitualment d’etiologia infecciosa que produeixen un insult pulmonar. La pneumònia associada a la ventilació mecànica i la infecció per SARS-CoV-2 ...
Valor pronóstico del estadiaje molecular ganglionar en el cáncer colorrectal mediante técnica OSNA
[spa] El cáncer colorrectal (CCR) representa la tercera neoplasia en incidencia a nivel mundial en ambos sexos y la segunda causa de muerte relacionada con cáncer en ambos sexos; suponiendo el primer cáncer en incidencia ...
Structural Genomic Alterations in Hepatocellular Carcinoma and Novel Combination Therapies
[eng] INTRODUCTION: Primary liver cancer is the sixth most diagnosed cancer and the second leading cause of cancer-related death worldwide. Around 90% of cases correspond to hepatocellular carcinoma (HCC), which normally ...
Uncovering novel biomarkers for Parkinson’s disease and its prodromal stages
[eng] Parkinson’s disease (PD) is the most common neurodegenerative movement disorder characterised by loss of dopaminergic neurons and the accumulation of aggregated α-synuclein. Clinical diagnosis is based on the appearance ...
