Programa de Doctorat en Biomedicina: Recent submissions
Now showing items 1141-1160 of 1378
Epidemiología del episodio depresivo mayor en España. Estudio descriptivo y análisis de resultados en el contexto europeo. Proyecto Esemed-España.
Objetivos del estudio: Describir la epidemiología del Episodio Depresivo Mayor (EDM) en la población general española y comparar los resultados con los datos reflejados en la literatura internacional. Métodos: Estudio ...
Evolutionary genetics of homo neanderthalensis :adaptive traits and methodological problems
The evolutionary history of H. neanderthalensis, interwoven with that of H. sapiens, has always fascinated the scientific world. Recent adavncess in paleogenetics shedds new light on the phylogenetic relationship between ...
Snail controls TGFB responsiveness and diferentiation of MS cells
The Snail1 transcriptional repressor is a key factor responsible in triggering epithelial to mesenchymal transition. Although Snail1 is widely expressed in early development, it is limited in adult animals to a subset of ...
Qualitat en l’anàlisi de drogues d’abús en cabell i en fluid oral
The use of hair and oral fluid for drugs of abuse testing has increased over the last years. For this reason, the assurance that results provided using these matrices are reliable and error-free is needed. The objective ...
Salud mental en jóvenes consumidores de cocaína o heroína de Barcelona
En nuestro país, los problemas derivados de la epidemia de consumo de heroína durante los años 80-90 se vieron desplazados por los derivados del consumo de cocaína. Actualmente, la cocaína es la segunda sustancia ilegal ...
Molecular determinants of TRPV4 channel regulation
TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. Due to this ...
Characterization of UL1, a member of the human cytomegalovirus RL11 gene family
In the present study, we have approached the molecular characterization of the HCMV specific UL1. To this end a HCMV (AD169-derived HB5 background) recombinant with an HA-epitope tagged UL1 and a mutant with a full UL1 ...
Development of synthetic biology devices for iron metabolism research
Synthetic biology is a fairly recent field that aims to engineer novel functions in biological systems. In a broad sense synthetic biology encompasses the development of tools that makes the engineering of biology easier. ...
Full characterization of the small RNA transcriptome using novel computational methods for high-throughput sequencing data: study of miRNA variability in eukaryote organisms.
In this thesis we have developed a user-friendly tool, SeqBuster, for the analysis of small RNA (sRNA) data generated by next generation sequencing strategies, with special emphasis on deep characterization of miRNA ...
Computational study of cancer
In my thesis, I focused on integrative analysis of high-throughput oncogenomic data. This was done in two parts: In the first part, I describe IntOGen, an integrative data mining tool for the study of cancer. This system ...
Molecular mechanisms underlying the effects of cannabinoids in the brain
The endocannabinoid system is an endogenous neuromodulatory system that regulates a plethora of physiological functions, including the control of movement, memory, anxiety, and pain, among others. Cannabinoid compounds are ...
The Action of natural selection in recently duplicated genes
Identification of signatures of positive selection has long been a major issue for understanding the unique features of any given species. However, only a fraction of human genes have been interrogated. Genes within ...
Functional analysis of JmjC+N histone demethylases in Drosophila melanogaster
La metilació de les lisines de les histones està implicada en les funcions associades a la cromatina, com l’expressió gènica o la formació d’heterocromatina. És una modificació covalent afegida per metiltransferases ...
The role of Cbx4/Polycomb-2 in epidermal stem cell homeostasis.
Human epidermis relies on a population of adult stem cells to maintain its homeostasis. Stem cells transit from a dormant to an active state and undergo a tightly regulated process of differentiation that replenishes the ...
Exposure to organochlorine compounds at the aerly stages of DDT use for indoor residual spraying in domestic environments in Manhiça, Mozambique.
Past and present uses of DDT and pyrethroids have led to their incorporation into humans, mainly through the food chain and sometimes by direct exposure. The present work focuses on establishing the levels of DDT, its ...
Measure and effect of diet in chronic obstructive pulmonary disease
Background and objectives: Recent research has shown an association between a healthy diet and reduced chronic obstructive pulmonary disease (COPD) incidence. However, the potential role of diet in COPD prognosis is ...
Cambios en la calidad de vida relacionada con la salud y uso de servicios sanitarios en niños y adolescentes españoles
El estudio KIDSCREEN Seguimiento analizó los cambios en la calidad de vida relacionada con la salud (CVRS) en una muestra representativa de niños y adolescentes españoles de 8 a 18 años de edad y sus padres, que contestaron ...
A unified approach to the emergence of complex communication
Aquesta tesi estudia l'emergència de complexitat en sistemes de comunicació naturals, prenent el llenguatge humà com a principal objecte d'estudi. Ens centrem en i) Patrons estadístics de complexitat, ii) Mecanismes ...
The role of NIMA-like kinase Nek9 in mitosis
Mitosis is the essential process during which a cell divides into two viable daughter cells. To allow a faithful segregation of the chromosomes into each daughter, the cell forms the bipolar spindle. The NIMA-like kinase ...
Modification on glycosidic enzyons as strategy to alter tumor
Alterations in the expression of carbohydrates and the enzymes involved in their synthesis (glycosidases and glycosyltransferases) can be considered as universal feature of malignant transformation. Iminosugars, monosaccharide ...
