Now showing items 9648-9667 of 11207

    Rol de la microbiota en pacientes con bronquiectasias no asociadas a la fibrosis quística 

    López Aladid, Rubén (Date of defense: 2022-10-20)

    [spa] El pulmón siempre se ha considerado estéril. Sin embargo, el campo de la microbiota pulmonar se ha visto revolucionado por el avance de las técnicas moleculares. Cada individuo tiene un perfil de microbiota único, ...

    Rol de la mitocòndria en el control de la homeòstasi cel·lular en planàries 

    Rosselló Xamena, Maria (Date of defense: 2021-12-10)

    El manteniment de l’homeòstasi en organismes adults és cabdal per la continuïtat dels individus; desregulacions d’aquest equilibri porten a l’aparició de malalties. La planària és un model d’estudi en regeneració i remodelació ...

    El rol de la sèrie documental en entorns de gestió dadificats: una proposta metodològica en el marc de la governança de la informació 

    Serra Serra, Jordi (Date of defense: 2024-02-02)

    [cat] La dialèctica sobre si l’objecte de la gestió documental ha d’incloure també la informació estructurada, o limitar-se només als documents, en tant que objectes discrets, es remunta a l’aparició de la tecnologia ...

    Rol de las proteínas α- y γ-sinucleína en la neurotransmisión dopaminérgica nigroestriatal y mesocortical: Implicación en enfermedades neurodegenerativas y trastornos neuropsiquiátricos 

    Pavia Collado, Rubén (Date of defense: 2020-11-06)

    [spa] Las sinucleínas son una familia de proteínas pequeñas y altamente conservadas en vertebrados, especialmente abundantes en las neuronas y típicamente enriquecidas en los terminales presinápticos, donde participan en ...

    Rol del gen de pigmentació MC1R en la susceptibilitat a malalties neurodegeneratives 

    Tell Martí, Gemma (Date of defense: 2018-05-07)

    El gen MC1R (codi OMIM: #155555) codifica pel receptor de la melanocortina 1 (MC1R) que s’expressa majoritàriament a la membrana dels melanòcits i està implicat en la regulació de la síntesi de melanina. El gen MC1R és ...

    Role and predictive value of the HDL function for cardiovascular disease in a high risk population. HDL function-linked markers and mechanisms 

    Soria Florido, María Trinidad (Date of defense: 2019-01-11)

    Cardiovascular disease remains the first cause of death worldwide. Pharmacological trials and Mendelian randomization studies have failed to unequivocally prove an inverse association between HDL-C levels and the risk of ...

    A role for heterochromatin and repetitive elements in epigenetic inheritance 

    Casas Masnou, Eduard (Date of defense: 2019-11-25)

    Gene regulation mechanisms control the level of transcription of each gene into RNA and the combination of expressed genes determines cell identity. Gene regulation is maintained by epigenetic mechanisms including DNA ...

    A role for the glutamate system in modern human language and cognition 

    O'Rourke, Thomas (Date of defense: 2021-04-27)

    The human capacity for language is made up of various cognitive subcomponents, the convergence of which allows our species a unique ability to relay our thoughts. Identifying these subcomponents and establishing how they ...

    The role of behavioural and feedback mechanisms in mediating herbivory processes in Mediterranean seagrass ecosystems 

    Buñuel Moreno, Xavier (Date of defense: 2021-07-13)

    The role of consumer-resource relationship is the basis of the structure and functioning of ecological communities. The traditional lens for studying such interactions have tended to omit the importance of the species ...

    Role of Capicua-L in RTK signaling and endocycle regulation 

    Rodríguez Muñoz, Laura (Date of defense: 2021-05-13)

    The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, Cic is expressed as ...

    Role of carnitine palmitoyltransferase 1A as a downstream effector of ghrelin in cortical neurons and hypothalamus 

    Mir Bonnín, Joan Francesc (Date of defense: 2016-07-11)

    Previous studies have reported the importance of carnitine palmitoyltransferase (CPT) 1A as an essential part of downstream ghrelin signaling in the central nervous system (CNS) for the control of food intake. Lipid ...

    The role of Caveolin-1 in the TGF-β-induced signalling in hepatocytes 

    Moreno Càceres, Joaquim (Date of defense: 2016-01-18)

    The transforming growth factor-beta (TGF-β) is a cytokine involved in many physiological and pathological processes. Its dual role has been described in the liver, where it can either induce pro- or anti-apoptotic signals. ...

    Role of CD44 in clear cell renal cell carcinoma invasiveness after antiangiogenic treatment 

    Aparicio García, María (Date of defense: 2020-12-09)

    [eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to develop different ...

    Role of CLA+T lymphocytes in the mechanisms triggering psoriasis 

    Jesús Gil, Carmen de (Date of defense: 2021-06-01)

    Psoriasis is a common immune-mediated inflammatory skin condition affecting around 2% of the population worldwide. Different disease subtypes have been described regarding their specific clinical phenotype: chronic plaques, ...

    The Role of Cognitive Ability in the Acquisition of Second Language Perceptual Phonological Competence 

    Safronova, Elena (Date of defense: 2016-11-04)

    Many second language (L2) learners find L2 pronunciation difficult and experience perception and production problems leading to accented speech. There exists a great inter-learner variation in L2 phonological acquisition ...

    Role of D-fagomine and omega-3 plyunsaturated fatty acids on gut microbia and related metabolic changes in healthy rats and in a model of fat-induced prediabetes 

    Hereu Planellas, Mercè (Date of defense: 2019-07-19)

    Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...

    Role of DOR/TP53INP2 in the control of muscle protein degradation = Papel de DOR/TP53INP2 en el control de la degradación de proteínas en el músculo esquelético 

    Martinez Cristobal, Paula (Date of defense: 2016-12-01)

    Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...

    Role of DPPA3 in hypoxia and tumour dormancy in cancer 

    Cuesta Borràs, Estefania (Date of defense: 2019-11-28)

    Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. Slow-cycling cancer ...

    Role of early postnatal nutrition during lactation in offspring metabolic health programming 

    Ribó Gené, Sílvia (Date of defense: 2017-12-01)

    Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...

    The role of FGF21 in the metabolic response to amino acid restriction 

    Pérez Martí, Albert (Date of defense: 2017-03-13)

    Obesity and associated metabolic diseases have reached epidemic proportions, affecting not only high-income countries but also low- and middle-income ones. In this context, the search for therapeutic approaches to treat ...