Recent Submissions

Charting the alternative splicing vulnerabilities of cancer 

Anglada Girotto, Miquel (Date of defense: 2025-02-27)

Cancer co-opts alternative splicing to select isoforms that promote disease initiation, progression, and persistence. Drugs targeting either cancer driver splicing factors or specific splicing events can hamper the disease. ...

Attributing heat-related mortality to climate change 

Beck, Thessa M. (Date of defense: 2025-02-21)

Climate change significantly exacerbates public health risks, particularly heat-related mortality. This PhD thesis examines the impact of human-induced climate change on heat-related deaths in Europe, focusing on regional ...

Evaluación del valor pronóstico de la ecografía pulmonar en el infarto agudo de miocardio con elevación del ST (LUS-AMI) 

Carreras Mora, José (Date of defense: 2025-02-21)

La insuficiencia cardíaca (IC) es un factor pronóstico crucial en pacientes con infarto agudo de miocardio con elevación del ST (IAMEST). La ecografía pulmonar es una técnica ampliamente estudiada en pacientes con insuficiencia ...

New insights into the clinical utility of LMO2 

Papaleo, Natalia (Date of defense: 2025-02-21)

This thesis offers novel information on the clinical utility of LMO2, shown in three different studies. In the first one, we generated a round-robin testing validating the interobserver and interlaboratory reproducibility ...

A novel computational framework for identifying epileptogenic networks based on functional connectivity changes 

Ivankovic, Karla (Date of defense: 2025-02-17)

Esta tesis se centra en mejorar la precisión de los objetivos quirúrgicos en pacientes con epilepsia resistente a los fármacos. Las redes cerebrales epileptogénicas exhiben cambios significativos en la conectividad durante ...

Dirección algorítmica en la relación laboral: derechos de información y consulta 

Peña Moncho, Juan (Date of defense: 2024-07-01)

El objetivo de esta tesis es analizar, desde un punto de vista interdisciplinar y transversal, los derechos de información y consulta derivados de la implantación de sistemas de dirección algorítmica en el ámbito laboral. ...

Beyond the Member State: Subnational Infringements of European Environmental Directives 

Wilhelm, Marie-Thérèse (Date of defense: 2024-11-28)

This dissertation examines the extent to which subnational authorities comply with European environmental directives. Problematic implementation of EU environmental legislation is well-known, but continued noncompliance ...

Worlds apart: The impact of (in)congruence on electoral behaviour: When voters and parties do not align 

Ioannidis, Nikandros (Date of defense: 2024-11-15)

This thesis provides a comprehensive analysis of the impact of ideological incongruence between voters and political parties on electoral behaviour in European democracies. It introduces a novel approach to measuring the ...

El impacto de la vivienda cooperativa en la salud de las personas: compartir para vivir 

Reyes Segura, Alexia (Date of defense: 2025-02-13)

El objetivo principal de esta tesis ha sido profundizar y ampliar en el conocimiento sobre la vivienda cooperativa y su impacto en la salud de las personas. Para alcanzar este objetivo, se han diseñado y llevado a cabo ...

Evaluation of topoisomers of snake venom-derived peptides as potential antimicrobial and antitumor agents 

Carrera, Adam (Date of defense: 2025-02-12)

This thesis reports an investigation of the effect of topoisomeric modification on the activity of two peptides: crotalicidin (Ctn), a cathelicidin from the venom of a South American rattlesnake, and Ctn[15-34], a Ctn ...

Evolutionary dynamics of cancer drug resistance and prediction of tumor modes of growth 

Dick, Nicola Elisabeth (Date of defense: 2025-02-11)

Cancer remains a significant challenge in healthcare and is a leading concern worldwide. Despite advances in cancer therapy and the identification of numerous actionable events, relapse and drug resistance continue to ...

Beyond Boundaries: Leveraging Visual Data for Advancements in Social Science Research 

Iglesias Muñoz, Patricia Andrea (Date of defense: 2024-11-22)

This thesis focuses on visual data collected in the frame of online surveys, examining the main challenges and implications of collecting and analyzing these new data types. Given the relatively unexplored implementation ...

Access of Migrant Women to Labor Market in Germany: Exploring the Barriers, Opportunities, and Experiences 

Yurdakul, Aslihan (Date of defense: 2025-11-17)

This dissertation is a mixed-method research project divided into three articles, each of which focuses on a different aspect of labor market integration for migrant women. The first chapter analyzes the experiences ...

Novel experimental strategies to characterize the genomic architecture of monogenic autoinflammatory diseases: from characterization of aberrant mRNA transcripts to elucidation of the role of post-zygotic variants in desease pathogenesis 

Bonet Martín, Núria (Date of defense: 2025-02-10)

Developments in sequencing technologies over the last decade have revolutionized the ability to identify the genetic mechanisms underlying rare autoinflammatory diseases (AIDs), enabling improved characterization and ...

The molecular mechanism of spindle pole focusing: NuMA as a dynein adaptor and microtubule minus end regulator 

Colombo, Sabina (Date of defense: 2025-02-07)

This project investigates the molecular mechanisms underlying chromosome segregation during eukaryotic cell division. Specifically, it explores the role of the motor protein cytoplasmic dynein 1 in maintaining metaphase ...

Unravelling the molecular pathways of auditory and vestibular function: the roles of sall1a and the fgf13 genes in the zebrafish inner ear development 

Montedeoca Vázquez, Nerea (Date of defense: 2025-01-31)

L’oïda interna és un òrgan sensorial complex essencial per a les funcions auditiva i vestibular, que depèn de les cèl·lules ciliades per a la mecanotransducció i de les neurones sensorials per a transmetre senyals al sistema ...

New strategies for targeting transactivation domains: insights from the androgen receptor 

Biesaga, Mateusz (Date of defense: 2022-11-28)

Transcription factors are, in theory, ideal targets for developing new therapies, as they drive the expression of genes, oftentimes those that lead to pathologies. However, these proteins typically contain large intrinsically ...

Skin microbiome engineering: new generation of therapeutics: engineering Cutibacterium acnes to treat skin conditions 

Knödlseder, Nastassia Johanna (Date of defense: 2023-01-27)

We are living in a symbiotic relationship with our Microbiome. This relationship with our microbes can become opportunistic and lead to dysbiosis. While we were previously treating dysbiosis with antimicrobial drugs, we ...

Elucidating the dynamics of the 3D GPCRome 

Aranda-García, David (Date of defense: 2025-01-30)

G Protein-Coupled Receptors (GPCRs) are a diverse protein family integral to a wide range of physiological processes. Although their three-dimensional structures have been extensively characterised through experimental ...

The KANSL complex, an epigenetic regulator with microtubule binding properties in mitosis 

Prat Oriol, Núria (Date of defense: 2025-01-24)

La segregació dels cromosomes durant la divisió cel·lular està mitjançada per una estructura feta de microtúbuls anomenada el fus mitòtic. L’estructura i la funció del fus mitòtic depenen d’un control precís de les dinàmiques ...