Universitat Pompeu Fabra
Now showing items 2034-2053 of 3254
The mechanisms by which amyloid beta (Aβ) causes synaptic dysfunction in Alzheimer’s disease (AD) remain elusive. Aβ is derived by sequential cleavage of the amyloid precursor protein (APP) and released from neurons, but ...
Animals perceive the external world through their sensory systems, which consists in: i) sensory receptors that detect external stimuli; ii) neuronal pathways that convey the sensory information to the brain; and iii) ...
Brain activity during rest exhibits a robust intrinsic spatio-temporal structure characterized by correlated patterns of neural activity. The study of the brain in altered states of vigilance or drug-induced brain states ...
This doctoral thesis presents two different computational approaches to explore mechanistically chondrocyte dysregulation and identify biomarkers, to better understand patient stratification systems in primary knee ...
This thesis analyses the processes undergone by mainstream media during the independence debate in Catalonia, focusing on the relationship among media, their audiences and governments through different empirical perspectives. ...
Esta tesis doctoral estudia la circulación de las traducciones literarias en formato libro entre Bulgaria y el mundo hispánico (España e Hispanoamérica) durante el periodo situado entre 1882 y 2012. La investigación se ...
Tobacco consumption is the leading cause of preventable cancer mortality worldwide and it is the origin of cardiovascular and respiratory diseases. Tobacco specific nitrosamines (TSNAs) are classified as type I carcinogens ...
En Perú, los grupos étnicos no eurodescendientes tienen escaso acceso a la participación mediática. En el discurso de los programas noticiosos, los afrodescendientes y los pueblos indígenas andinos y amazónicos tienden a ...
Music was the first mass-market industry to be completely restructured by digital technology, and today we can have access to thousands of tracks stored locally on our smartphone and millions of tracks through cloud-based ...
Esta tesis propone un enfoque socio-cognitivo para analizar procesos discursivos de memoria autobiográfica y colectiva. Esta nueva perspetiva interdisciplinaria en estudios de memoria integra teorías de estudios del discurso, ...
Les tecnologies de seqüenciació de nova generació (NGS) han emergit com a una poderosa eina per al descobriment de mutacions causals i nous gens per a malalties Mendelianes, i estan tenint un ràpid impacte en l’àmbit del ...
Homotypic and heterotypic cell-cell fusion are key processes during development and tissue regeneration. On the other hand, aberrant heterotypic cell fusion between cancer and normal cells can contribute to tumor initiation ...
This thesis covers a number of technical developments, to improve mesoscopic imaging and analysis, with a focus on quantitative imaging. The main topic is attenuation in light sheet fluorescence microscopies (LSFM). ...
Small cell lung carcinoma (SCLC) is a highly lethal disease due to its chemorefractory nature after first line treatment. The mechanisms to overcome this resistance have remained elusive to tackle up to date. MET is a ...
One of the main evolutionary transitions is the origin of animal and fungal multicellularity from single-cell ancestors. To address this change, it is necessary to study the extant unicellular relatives of animals (Metazoa) ...
Tumors are complex tissues composed by multiple cell types, such as cancer associated fibroblasts (CAFs), that facilitate the invasive behavior of tumor cells. When we examined their nutrient requirements, we observed that ...
Hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol], a potent bioactive molecule mainly present in virgin olive oil and to a lower extent in wine, is also a by-product of dopamine metabolism. In a previous clinical trial ...
Drug metabolism studies provide the opportunity to enhance metabolic properties of new drugs. The overall aims of the drug metabolism studies are to (1.) optimize pharmacokinetic properties of the drug candidates, (2.) ...
Este trabajo presenta un estudio empírico del uso y función del metalenguaje en el conocimiento científico experto y los lenguajes de especialidad en lengua inglesa, con especial atención al establecimiento, modificación ...
Obesity is a pressing health issue and a popular topic in Chinese media. This PhD thesis investigates the metaphors used to talk about obesity in Chinese media. Specifically, this thesis compares the editorials in the ...
