Universitat Pompeu Fabra: Recent submissions
Now showing items 1-20 of 3325
Fixing a broken heart: Zebrafish as a model for heart regeneration drug discovery
Myocardial infarction (MI) remains a leading cause of mortality, with currently available treatments addressing symptoms rather than promoting heart muscle regeneration. Cardiac regeneration strategies, inspired by ...
Genomic analysis of demographic changes in Southern Europe during Roman colonization and Late Antiquity
The expansion of the Roman Empire throughout the Mediterranean region and West Eurasia severely shaped the world culturally and politically. This period has been traditionally studied and researched by historians and ...
Temperature impacts on mortality at different spatial and temporal scales
This PhD thesis investigates the relationship between temperature and mortality at different spatial and temporal scales, addressing a crucial issue in the context of rising temperatures due to anthropogenic climate change. ...
High resolution 3D modelling of lumbar spine from MRI using deep learning
This thesis addresses the growing problem of degenerative disorders of the intervertebral discs (IVD). Intervertebral Disc Degeneration (IDD) represents a progressive degradation of the IVDs compromising their biomechanical ...
Phylogenetic applications of ancient protein sequences
The resilience of proteins against degradation makes them the longest surviving resource for genomic information. Knowing how much information we can obtain from an ancient sample is crucial because most sampling strategies ...
Object naming from lexical systems to language use and back
When referring to the objects they see, speakers choose a word from the lexical system to name them. This process involves using a word with a general meaning to refer to a specific object, which possesses unique features ...
Temporal Topographies: an analysis of a colonial present
La tesis presenta un estudio de la fundación ontológica de la temporalidad y la historicidad en el pensamiento filosófico occidental. Realiza una revisión teórica del dominio del tiempo sobre el espacio y argumenta ...
Germanofilia y <neutralismo>: Un estudio sobre los germanófilos españoles durante la Primera Guerra Mundial
Esta tesis tiene como objetivo estudiar a los germanófilos españoles durante la Primera Guerra Mundial. En ella se examinan las iniciativas llevadas a cabo por este sector de la opinión pública española, que se formó poco ...
Analyzing the role of cancer-associated adipocytes in brest tumor metastasis
In breast cancer, the tumor microenvironment includes adipocytes and fibroblasts. When in contact with breast tumor cells, adipocytes undergo lipolysis and dedifferentiation. This thesis demonstrates that cancer-associated ...
Al modelling of real-world patients: applications in prostate cancer
This thesis investigates the integration and analysis of OMICs data to enhance in silico modelling of real-world patients, with a special focus on prostate cancer. By leveraging publicly available transcriptomics data, ...
Urban heat islands and nature-based solutions: insights into health impacts and urban planning determinants
The current and projected rapid urbanization rates underscore the critical role of cities and the urgent need to prioritize the development of healthy and sustainable urban environments. Rising temperatures, intensified ...
A multiscale spatiotemporal map of protein-RNA assemblies in human cells
RNA metabolism is dynamically orchestrated by RNA-binding proteins (RBPs) in different subcellular spaces. Aberrant regulation of the subcellular RNA-protein interactions leads to severe diseases, such as neural degenerations ...
Somatic and germline mutational processes and the evolution of cancer drives genes
Cancer develops from healthy cells due to mutations in around 600 cancer driver genes. These mutations, along with neutral ones, are generated from DNA mutational processes, creating distinct patterns known as mutational ...
Industrial augmented reality prototypes in the field of art authoring, dissemination, and consumption tools for artistic content on mobile devices with a focus generation Z
The advent of spatial content and increasingly advanced mixed reality devices is set to revolutionise the manner in which we interact with digital content, becoming the predominant human-computer interface in the ...
Deep audio representation learning for music using weak supervision
Music audio tagging is the Music Information Retrieval task of assigning one or multiple labels to an audio signal. Current state-of-the-art music taggers rely on deep learning approaches, which offer high performance ...
Synthetic biology for microbiome-based genetic domestication of the skin and the sea
Microorganisms exhibit remarkable adaptability and represent a vast genetic resource. Synthetic biology aims to leverage this diversity for sustainability and medicine. However, many microbes remain unexplored due to limited ...
Violin perfomance analysis using weak supervision
This thesis investigates the development of core Music Information Retrieval (MIR) technologies for Violin Performance Analysis, addressing both data and label scarcity. To mitigate data scarcity, the Violin Repertoire ...
Enhancing environmental risk scores with informed machine learning and explainable AI
This thesis explores the development of Environmental Risk Scores (ERSs) that go beyond traditional linear models to capture nonlinear relationships and interactions among a wide range of environmental exposures. Utilizing ...
Investigating cellular hierarchies in acute myeloid leukemia using single-cell genomics
Acute myeloid leukemia is an aggressive type of blood cancer with a poor survival rate. Leukemic stem cells (LSCs) govern the disease by producing rapidly dividing progenitor cells and driving relapse. Molecular characterization ...
Exposure to disinfection by-products and per- and polyfluoroalkyl substances in Barcelona's drinking water and associations with early life outcomes
Los productos químicos como los subproductos de desinfección (DBP) y las sustancias per- y polifluoroalquiladas (PFAS) se encuentran en el agua potable debido a su formación en los sistemas de distribución o su eliminación ...
