Universitat Pompeu Fabra: Recent submissions
Now showing items 241-260 of 3276
Advanced microscopy to resolve the higher-order organization of the exocyst
The exocyst is an heterooctameric protein complex that tethers secretory vesicles to the plasma membrane during exocytosis. Each exocytic event is mediated by 10-15 exocysts. However, how multiple exocysts organize in time ...
Essays on the credit market and macroeconomic policy
This dissertation consists of three essays. In the first chapter, using a series of identified monetary policy shocks for Peru, I show robust evidence of supply side mechanisms of monetary policy for the credit market ...
Transcriptomic determinants of vertebrate photoreceptors and other sensory cells
The nervous system comprises an immense number of cells that serve highly specialized roles. Accordingly, they possess unique morphological and functional attributes, greatly shaped by specific Alternative Splicing (AS) ...
Investigating sperm RNA dynamics in intergenerational inheritance using nanopore sequencing
The aim of this thesis is to delve into sperm RNA dynamics during maturation and paternal inheritance. To obtain an integrative multi-omics view of sperm RNA during these processes, I turned to the new direct RNA sequencing ...
Precariedad laboral, estrés crónico y salud mental: un estudio sobre el entorno psicosocial laboral como posible mecanismo causal
El objetivo principal de esta tesis fue analizar el posible papel mediador del entorno psicosocial del trabajo en la relación entre la precariedad laboral, la salud mental y el estrés crónico. Se combinaron diferentes ...
Conservation through the lens of population genomics: the case of Cuvier's gazelles and western gorillas
The field of genomics can be used to help in threatened species conservation by guiding conservation efforts. In this thesis we have studied Cuvier’s gazelles to compare the genetic diversity and inbreeding between the ...
Computational analysis of ribonucleoprotein networks
Ribonucleoprotein condensates such as stress granules (SGs) and processing bodies (PBs) form in response to specific stimuli in the cell. Even though the key protein and RNA elements of these condensates are starting to ...
Evolutionary insights into primate gene regulation and development of methods to study DNA modifications
Changes in the epigenetic regulation of gene expression have important implications for evolution. However, the study of these changes (i) has not been consistently assessed across closely related species, (ii) oftentimes ...
An in silico clinical trial platform based on systems biology approaches
El procés de descobriment i desenvolupament de fàrmacs (DDD) és costós tant econòmic com temporalment, i el qual resulta en nivells d'èxit molt reduïts. Una gran quantitat de compostos son analitzats i molts descartats en ...
Engram pathology in Down syndrome: molecular and cellular mechanisms
Down syndrome (DS) is the most common genetic form of intellectual disability and arises from the partial or total trisomy of the Homo Sapiens Autosome 21. The cellular and molecular mechanisms that contribute to memory ...
Re-thinking large scale hate speech identification: beyond common NLP conventions and supervised machine learning
The detection of hate speech in online spaces is traditionally conceptualized as a classification task that uses Machine Learning (ML)-driven Natural Language Processing (NLP) techniques. In accordance with this ...
Disfunción muscular en pacientes con EPOC: papel del estrés en el retículo endoplasmático y la alteración del potencial regenerativo
Se ha estudiado el potencial de regeneración muscular en pacientes EPOC con y sin sarcopenia. También se ha investigado otro mecanismo de regeneración muscular mediante el análisis del estrés a nivel de retículo endoplasmático ...
Cancer risk among children exposed to medical ionising radiation and modifying factors - evidence from paediatric CT exposure in Sweden
Though Computed Tomography (CT) plays an essential role in healthcare, several large-scale cohort studies have reported an increased cancer risk following CT-radiation exposure in childhood. Results may be subject to ...
Characterization of iron deficiency in COPD patiens: implications in exercise tolerance and redox balance in muscle and systemic compartments
Chronic obstructive pulmonary disease (COPD) patients may present different types of systemic manifestations. Iron deficiency (ID) (Fe, an essential nutritional element) is common and can negatively affect exercise tolerance ...
Sexual identity and adverse health-related outcomes: a study on risk behaviour, suicide, and substance use
This PhD dissertation addresses how stress regarding one’s sexual identity relates to health-related adverse outcomes. It is composed of four articles. The first one examines how internalized homonegativity (IH) is ...
Music enhances second language pronunciation acquisition: the benefits of songs and embodied rhythmic and melodic activities
In the last decades, a growing number of studies have investigated the relationship between two unique abilities of humankind, music and language. Music and language share important structural similarities related to ...
El Oro negro de la ciudad: una etnografia sobre la producción del sujeto mantero y su voz
La voz como problema ha sido abordado desde distintos campos. Se ha identificado filosóficamente con la capacidad intrínsecamente humana de narrar la propia historia. En relación a la movilización social, se ha visto ...
La Tutela ejecutiva en el sistema interamericano de derechos humanos: hacia un estándar convencional de efectividad
La presente investigación realiza un estudio de las problemáticas en torno al cumplimiento y ejecución de las sentencias de la Corte Interamericana de Derechos Humanos, uno de los principales desafíos actuales que se ...
La comprobación de operaciones vinculadas en el impuesto sobre sociedades español: límites a la interpretación desde una perspectiva internacional, comunitaria y nacional
En este trabajo se aborda el estudio del régimen jurídico de las operaciones entre sociedades vinculadas y los precios de transferencia en el Derecho internacional tributario, el Derecho de la Unión Europea y el Derecho ...
La responsabilidad penal en la relación materno y paternofilial: una reinterpretación
Una vez demostrada la inconveniencia de los fundamentos ensayados hasta el momento de la responsabilidad penal de las madres y los padres por el cuidado de sus hijos (que no permiten una aplicación equitativa del derecho), ...
