Biomarcadors pronòstics de ressonància magnètica en pacients amb glioblastoma de diagnòstic recent 

    Gimeno Cajal, Alfredo Eduardo (Date of defense: 2022-04-22)

    Magnetic resonance imaging (MRI) is essential in the management of patients with glioblastoma, providing useful information for diagnosis, prognosis, and therapeutic planning. Although some presurgical and postsurgical ...

    Caracterización de polimorfismos genéticos implicados con el metabolismo de la citarabina y asociación con la respuesta y toxicidad a la quimioterapia en pacientes con leucemia mieloide aguda de riesgo intermedio 

    Díaz Santa, Johana Alejandra (Date of defense: 2022-12-16)

    Acute myeloid leukemia (AML) is adults' most common acute leukemia. Prognostic factors influencing treatment response and patient survival are diverse, the most relevant being those associated with specific cytogenetic and ...

    Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018 

    Carbó Bagué, Anna (Date of defense: 2023-03-27)

    In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of ...

    Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada 

    Farrés Coll, Ramon (Date of defense: 2023-03-10)

    Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...

    Desenvolupament i beneficis per a la salut d'una aplicació mòbil basada en els problemes pediàtrics no urgents 

    Perruca Martínez, Cristina (Date of defense: 2022-03-04)

    The lack of knowledge and skills in the care of infants in their first years of life often results in frequent paediatric consultations for banal problems and doubts, which are often a result of a low level of health ...

    Design and fabrication of three-dimensional scaffolds for breast cancer stem cell expansion and molecular characterization 

    Rabionet Diaz, Marc (Date of defense: 2021-11-08)

    Triple negative breast cancer (TNBC) accounts for 15-20% of the breast cancers and displays an aggressive profile, poor prognosis, high relapse risk and does not have a targeted therapy. In the last years, breast cancer ...

    DNA methylome in HER2-positive resistant breast cancer 

    Palomeras, Sònia (Date of defense: 2019-02-27)

    The major clinical problem for HER2+ breast cancer target therapies is the acquisition of resistance. The DNA methylation status of the promoter gene region has been described as a common epigenetic alteration for ...

    Estudi epidemiològic poblacional de la incidència, tendència i supervivència de les neoplàsies limfoides a la província de Girona durant un període de 20 anys (1996-2015) 

    Auñón Sanz, M. del Carmen (Date of defense: 2020-11-20)

    The incidence, time trends and survival of lymphoid neoplasm’s in the Girona province are analyzed from 1996 to 2015. The survival of diffuse large B-cell lymphoma (LBDCG) before and after 2004 and estimate incidence rate ...

    Estudio del impacto de UGT2B17 y PD-1 en el trasplante alogénico de progenitores hematopoyéticos a partir de donante emparentado HLA idéntico 

    Santos Carvajal, Nazly (Date of defense: 2022-11-25)

    Study of the impact of UGT2B17 and PD-1 on allogeneic transplantation of hematopoietic progenitors (allo-TPH) from HLA-identical related donor. everal genetic factors can favor the development of graft-versus-host disease ...

    Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent 

    Pigem Rodeja, Anna (Date of defense: 2023-03-03)

    INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...

    Fatty acid synthase expression and inhibition in cancer 

    Blancafort Jorquera, Adriana (Date of defense: 2016-01-29)

    In this thesis,the association of FASN (fatty acid synthase) expression with clinicopathological and anthropometric characteristics in breast cancer patients is studied to find out FASN role as a prognostic in early stage ...

    Fatty acid synthase expression and inhibition in triple-negative breast cancer 

    Giró Perafita, Ariadna (Date of defense: 2017-01-17)

    Triple-negative breast cancer (TNBC) represents 20% of breast cancer and patients receive only general chemotherapy. The epidermal growth factor receptor (EGFR) is commonly expressed in TNBC and it is associated with poor ...

    Impacte clínic del càlcul de la dosi absorbida en radioteràpia externa mitjançant un nou algorisme basat en la solució de l'equació de Boltzmann 

    Muñoz Montplet, Carles (Date of defense: 2022-03-01)

    The algorithm for calculating absorbed dose in external radiotherapy Acuros XB (AXB), based on the solution of the Boltzmann equation, has shown to achieve a higher level of accuracy than the preceding convolution/superposition ...

    New approaches for the study and treatment of aggressive cancers 

    Polonio Alcalá, Emma (Date of defense: 2023-05-17)

    Although there are therapies for triple negative breast cancer (TNBC) and epidermal growth factor-mutated non-small cell lung cancer (EGFRm NSCLC), these two subtypes of cancer are very aggressive, and most patients develop ...

    Polimorfismos de los genes moduladores de la respuesta inmune como predictores de recaída en los pacientes con mieloma múltiple 

    Gonzalez Montes, Yolanda (Date of defense: 2024-04-12)

    Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...

    Programa d'intervenció familiar multidisciplinar en atenció primària de salut basat en la teràpia de resolució de problemes per la disminució de la utilització dels recursos sanitaris del pacient crònic complex 

    Guerrero Caballero, Laura (Date of defense: 2021-12-16)

    Introduction: In the current socioeconomic context, addressing chronic diseases forces us to seek new, more efficient, strategies for complex chronic patients care. Family care can improve complex chronic patient management, ...

    The flavonolignan silibinin in non-small cell lung cancer: molecular mechanisms and therapeutic relevance 

    Verdura Martínez, Sara (Date of defense: 2024-06-07)

    Non-small cell lung cancer (NSCLC) is a challenging disease to treat. Despite several decades of improved clinical progress, there is an unmet need to investigate how therapeutic resistance develops. In particular, managing ...