Àrea de contingut
Universitat de Girona
Browsing Departament de Ciències Mèdiques by Subject "616"
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Abordaje laparoscópico 3D de la patología suprarrenal
ENG- Introduction: Laparoscopic adrenalectomy, introduced in the 1990s, replaced open surgery as the gold standard. While advantageous, 2D vision has limitations in depth perception, addressed by 3D systems. This study ...
Analysis of microbiota patterns linked to pancreatic cancer and their role in host inflammation, oxidative stress, and immune status
ENG- Pancreatic cancer (PDAC) is becoming more common, especially in developed countries, due to risk factors like smoking and alcohol-related chronic pancreatitis (CP). Its hidden location often causes late-stage diagnosis, ...
Biomarcadors pronòstics de ressonància magnètica en pacients amb glioblastoma de diagnòstic recent
Magnetic resonance imaging (MRI) is essential in the management of patients with glioblastoma, providing useful information for diagnosis, prognosis, and therapeutic planning. Although some presurgical and postsurgical ...
Caracterización de polimorfismos genéticos implicados con el metabolismo de la citarabina y asociación con la respuesta y toxicidad a la quimioterapia en pacientes con leucemia mieloide aguda de riesgo intermedio
Acute myeloid leukemia (AML) is adults' most common acute leukemia. Prognostic factors influencing treatment response and patient survival are diverse, the most relevant being those associated with specific cytogenetic and ...
Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of ...
Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada
Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...
Desenvolupament i beneficis per a la salut d'una aplicació mòbil basada en els problemes pediàtrics no urgents
The lack of knowledge and skills in the care of infants in their first years of life often results in frequent paediatric consultations for banal problems and doubts, which are often a result of a low level of health ...
Desenvolupament i implementació clínica d’un nou dispositiu en tècniques d’inspiració forçada mantinguda en tractaments de càncer de mama esquerra amb radioteràpia externa per reduir la dosi al cor
ENG- The radiotherapy treatment for left breast cancer is widely described. One of the long-term undesirable effects of radiotherapy is heart disease, which often manifests as ischemia or myocardial infarction, especially ...
Design and fabrication of three-dimensional scaffolds for breast cancer stem cell expansion and molecular characterization
Triple negative breast cancer (TNBC) accounts for 15-20% of the breast cancers and displays an aggressive profile, poor prognosis, high relapse risk and does not have a targeted therapy. In the last years, breast cancer ...
DNA methylome in HER2-positive resistant breast cancer
The major clinical problem for HER2+ breast cancer target therapies is the acquisition of resistance. The DNA methylation status of the promoter gene region has been described as a common epigenetic alteration for ...
Estudi epidemiològic poblacional de la incidència, tendència i supervivència de les neoplàsies limfoides a la província de Girona durant un període de 20 anys (1996-2015)
The incidence, time trends and survival of lymphoid neoplasm’s in the Girona province are analyzed from 1996 to 2015. The survival of diffuse large B-cell lymphoma (LBDCG) before and after 2004 and estimate incidence rate ...
Estudio del impacto de UGT2B17 y PD-1 en el trasplante alogénico de progenitores hematopoyéticos a partir de donante emparentado HLA idéntico
Study of the impact of UGT2B17 and PD-1 on allogeneic transplantation of hematopoietic progenitors (allo-TPH) from HLA-identical related donor. everal genetic factors can favor the development of graft-versus-host disease ...
Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent
INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...
Fatty acid synthase expression and inhibition in cancer
In this thesis,the association of FASN (fatty acid synthase) expression with clinicopathological and anthropometric characteristics in breast cancer patients is studied to find out FASN role as a prognostic in early stage ...
Fatty acid synthase expression and inhibition in triple-negative breast cancer
Triple-negative breast cancer (TNBC) represents 20% of breast cancer and patients receive only general chemotherapy. The epidermal growth factor receptor (EGFR) is commonly expressed in TNBC and it is associated with poor ...
Fenotipado de las mutaciones NRAS en cáncer colorrectal: caracterización clínico-molecular y búsqueda de nuevas terapias
ENG- Metastatic colorectal cancer (mCRC) remains a major medical challenge, particularly in the search for effective treatments such as epidermal growth factor receptor (EGFR)-targeted therapies. While mutations in the ...
Impacte clínic del càlcul de la dosi absorbida en radioteràpia externa mitjançant un nou algorisme basat en la solució de l'equació de Boltzmann
The algorithm for calculating absorbed dose in external radiotherapy Acuros XB (AXB), based on the solution of the Boltzmann equation, has shown to achieve a higher level of accuracy than the preceding convolution/superposition ...
New approaches for the study and treatment of aggressive cancers
Although there are therapies for triple negative breast cancer (TNBC) and epidermal growth factor-mutated non-small cell lung cancer (EGFRm NSCLC), these two subtypes of cancer are very aggressive, and most patients develop ...
Optimització del procés de tractament actual dels pacients amb tumors localment avançats de laringe/hipofaringe: validació de factors pronòstics clínics de preservació d’òrgan i processament volumètric en la delimitació dels volums de tractament radioteràpic
ENG- This study analyzes the treatment of locally advanced laryngeal and hypopharyngeal tumors, focusing on two key areas: the validation of the TALK protocol and the use of the Smoothing tool in radiotherapy. - Validation ...
Polimorfismos de los genes moduladores de la respuesta inmune como predictores de recaída en los pacientes con mieloma múltiple
Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...
