Departament de Ciències Mèdiques: Recent submissions
Now showing items 1-20 of 112
Desenvolupament i implementació clínica d’un nou dispositiu en tècniques d’inspiració forçada mantinguda en tractaments de càncer de mama esquerra amb radioteràpia externa per reduir la dosi al cor
ENG- The radiotherapy treatment for left breast cancer is widely described. One of the long-term undesirable effects of radiotherapy is heart disease, which often manifests as ischemia or myocardial infarction, especially ...
L’elastografia ecogràfica per avaluar l’elasticitat muscular en els infants amb paràlisi cerebral
ENG- Introduction: Children with spastic cerebral palsy (CP) suffer from biomechanical changes in their muscles, causing excessive spasticity. These changes in muscle tone can be estimated by means of clinical scales or ...
Estudi de la malaltia ateroscleròtica subclínica en pacients amb diabetis tipus 1 de la regió sanitària de Girona
ENG- Cardiovascular diseases (CVDs) are the leading cause of death and illness in people with type 1 diabetes (T1D). However, the traditional prediction models for cardiovascular events, which are based on common risk ...
TGFβI gene promoter methylation as a biomarker of resistance to anti-HER2 therapies in HER2-positive breast cancer
ENG- HER2 positive breast cancer represents approximately 15-20% of breast cancer and it is associated with higher grade, more aggressive phenotype and worse prognosis. The prognosis of these patients has dramatically ...
Unravelling the relevance of Plakophilin-2 and Olfactomedin-2 in obesity
ENG- Obesity is a complex chronic disease linked to adipocyte dysfunction and a low-grade inflammatory condition leading to the impaired synthetic and secretory activity of hyperplastic depots of adipose tissue. As a ...
New insights in the study of the physiology of the adipose tissue
ENG- The prevalence of obesity has increased dramatically in recent years and has reached epidemic proportions. Obesity is a chronic multifactorial disease associated with an abnormal accumulation of dysfunctional adipose ...
Identificación y caracterización de nuevos biomarcadores para el diagnóstico de la miocardiopatía dilatada
ENG- Atherosclerotic cardiovascular diseases are efficiently treated with statins. These medications can cause unwanted muscle problems in some patients, leading them to discontinue treatment. In this context, the ...
Impact of serum ferritin and metformin on cognitive function in middle-aged subjects: modulation by the gut microbiome
ENG- The global obesity epidemic represents a major threat to public health worldwide. Obesity is associated with many complications that reduce quality of life and longevity. Complications associated with obesity include ...
Fenotipado de las mutaciones NRAS en cáncer colorrectal: caracterización clínico-molecular y búsqueda de nuevas terapias
ENG- Metastatic colorectal cancer (mCRC) remains a major medical challenge, particularly in the search for effective treatments such as epidermal growth factor receptor (EGFR)-targeted therapies. While mutations in the ...
Fatty acids profile and DNA methylation in the placenta: prevention of cardiometabolic risk and obesity in childhood
ENG- The increase in the prevalence of obesity worldwide over the past 50 years has led to obesity being considered the pandemic of the 21st century. Overweight and obesity are under scrutiny because the current pediatric ...
Study of endothelial dysfunction in chronic thromboembolic pulmonary hypertension and in COVID-19. Biomarkers and new targeted therapeutic strategies
The endothelium, the lining of our blood vessels, plays a crucial role in controlling functions such as blood flow, clotting and inflammation. When it does not function properly, called endothelial dysfunction, it can lead ...
Exploration into non-traditional risk factors of subclinical atherosclerosis in low-risk adults
Background: Atherosclerotic cardiovascular disease (ASCVD) manifests silently as subclinical atherosclerosis before a clinical event. Disparities in ASCVD risk, particularly among underrepresented ethnic and racial groups, ...
The flavonolignan silibinin in non-small cell lung cancer: molecular mechanisms and therapeutic relevance
Non-small cell lung cancer (NSCLC) is a challenging disease to treat. Despite several decades of improved clinical progress, there is an unmet need to investigate how therapeutic resistance develops. In particular, managing ...
Polimorfismos de los genes moduladores de la respuesta inmune como predictores de recaída en los pacientes con mieloma múltiple
Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...
Síndrome de l’espai gluti profund (deep gluteal syndrome). Bases anatòmiques de la seva fisiopatologia i indicacions quirúrgiques
Pain in the buttock region without lumbar pathology will lead us to focus the study on the region of the subgluteal space. This is defined as the deep gluteal syndrome. The deep gluteal syndrome is a condition with a very ...
Complicacions perioperatòries de l’adrenalectomia laparoscòpica. Experiència a la província de Girona
INTRODUCTION: Adrenal masses are one of the most common tumors, being incidentally diagnosed in 5% of patients undergoing imaging tests. Until the beginning of the 1990s, all adrenal surgical treatment was performed through ...
El nivell i la variació del risc cardiovascular en la prevenció primària de la demència
Dementia causes progressive cognitive impairment and inability to lead an independent life. Currently, there is no curative treatment for it, and thus primary prevention is essential. Age is the main risk factor for ...
Predicción del riesgo cardiovascular en población de 75 o más años del Mediterráneo
The increase of elderly population in Spain is one of the most important challenges for their caregivers, healthcare professionals, and the society in general. The elderly population has the highest incidence rate of ...
Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...
Posible rol de las neuregulinas en la fisiología del tejido adiposo en asociación con obesidad y diabetes mellitus tipo 2
Different studies link the metabolic alterations of obesity with imbalances in neuregulin 4 levels. In this study we hypothesize that signaling of neuregulin isoforms (NRG) produced through ERBB receptors in human adipose ...
