Departament de Ciències Mèdiques: Recent submissions
Now showing items 21-40 of 102
Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification
Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...
Caracterización de polimorfismos genéticos implicados con el metabolismo de la citarabina y asociación con la respuesta y toxicidad a la quimioterapia en pacientes con leucemia mieloide aguda de riesgo intermedio
Acute myeloid leukemia (AML) is adults' most common acute leukemia. Prognostic factors influencing treatment response and patient survival are diverse, the most relevant being those associated with specific cytogenetic and ...
Estudio del impacto de UGT2B17 y PD-1 en el trasplante alogénico de progenitores hematopoyéticos a partir de donante emparentado HLA idéntico
Study of the impact of UGT2B17 and PD-1 on allogeneic transplantation of hematopoietic progenitors (allo-TPH) from HLA-identical related donor. everal genetic factors can favor the development of graft-versus-host disease ...
Identificación y caracterización de factores de transcripción implicados en la regulación de procesos moleculares y cerebroreparadores en el ictus
The aim of this thesis was to identify transcriptional regulators involved in the modulation of ischaemia, as well as brain plasticity processes responsible for compensating the ischaemic lesions, in order to establish the ...
Reinterpretació de les variants genètiques identificades en una unitat especialitzada en cardiopaties familiars
Sudden cardiac death (SCD) is defined as a natural and unexpected death due to cardiac etiology. In addition, when the cause of death remains unexplained after a complete autopsy, a cardiac arrhythmia is suspected as a ...
Valoració dels canvis que pateix la uretra durant l’embaràs objectivats per ecografia 2D i la relació d’aquests amb l’aparició d’incontinència d’orina en la gestació
Urinary incontinence (UI) is a dysfunction that has a very negative impact on the quality of life of women who suffer from it (low self-esteem, shame, restriction of social contacts, etc.). Different factors involved in ...
L’àcid úric, el greix perirenal i la mida renal com a nous marcadors de risc cardiovascular en població pediàtrica sana
Despite notable advances in health promotion over the past decades, cardiovascular disease remains the leading cause of death worldwide, with obesity being a rising contributor of it. Cardiovascular risk factors appear in ...
Estudio anatómico y funcional del ligamento colateral ulnar lateral. Análisis de su papel en la inestabilidad postero-lateral
We performed a descriptive and functional experimental study in various phases of the lateral elbow liamentous complex (LCL), with special relevance to the function of the lateral ulnar collateral ligament (LCUL). Initially,we ...
Algoritme diagnòstic en el laboratori. Impacte dels nous índex hematimètrics
Currently, automatic analyzers based on highly accurate methods can determine hematologic parameters in a fast and reliable way which is important to detect abnormalities in blood cells. In laboratories with a high care ...
Eficacia de los fármacos antihipertensivos en monoterapia y combinación
Background. The relative efficacy of antihypertensive drugs/combinations is not well known; Identifying the most effective ones, and the patients’ characteristics associated to best performance of the drugs will improve ...
Cognitive function in obesity: interactions with the gut microbiome
Obesity is considered a modifiable risk factor for cognitive impairment which, in turn, predisposes to overeating and weight gain. Compelling evidence in animal models has demonstrated the impact of the gut microbiome on ...
Cribratge i diagnòstic de la malaltia renal crònica en població adulta menor de 65 anys d’edat, de risc elevat, en l’àmbit de l’atenció primària de salut
Chronic kidney disease is due to different causes and its recognition is important for its association with an increased cardiovascular risk. This risk is increased in association with chronic conditions such as high blood ...
Biomarcadors pronòstics de ressonància magnètica en pacients amb glioblastoma de diagnòstic recent
Magnetic resonance imaging (MRI) is essential in the management of patients with glioblastoma, providing useful information for diagnosis, prognosis, and therapeutic planning. Although some presurgical and postsurgical ...
Grape stalk and coffee polyphenolic extracts administration as new pharmacological strategies to modulate spinal cord injury-induced neuropathic pain in mice
More than half of spinal cord injury patients develop central neuropathic pain, which is largely refractory to current treatments. Developing neuropathic pain has a high impact on the quality of life becoming an emotional, ...
Impacte clínic del càlcul de la dosi absorbida en radioteràpia externa mitjançant un nou algorisme basat en la solució de l'equació de Boltzmann
The algorithm for calculating absorbed dose in external radiotherapy Acuros XB (AXB), based on the solution of the Boltzmann equation, has shown to achieve a higher level of accuracy than the preceding convolution/superposition ...
Desenvolupament i beneficis per a la salut d'una aplicació mòbil basada en els problemes pediàtrics no urgents
The lack of knowledge and skills in the care of infants in their first years of life often results in frequent paediatric consultations for banal problems and doubts, which are often a result of a low level of health ...
Design and fabrication of three-dimensional scaffolds for breast cancer stem cell expansion and molecular characterization
Triple negative breast cancer (TNBC) accounts for 15-20% of the breast cancers and displays an aggressive profile, poor prognosis, high relapse risk and does not have a targeted therapy. In the last years, breast cancer ...
Monitoratge de la malaltia inflamatòria intestinal en la pràctica clínica mitjançant marcadors de la microbiota intestinal en mostres fecals. Estudi prospectiu
The gut microbiota (GM) plays a pivotal role in the maintenance of gut homeostasis, and the pathogenesis of inflammatory bowel disease (IBD) which includes Crohn's disease (CD) and ulcerative colitis (UC). The degree of ...
Programa d'intervenció familiar multidisciplinar en atenció primària de salut basat en la teràpia de resolució de problemes per la disminució de la utilització dels recursos sanitaris del pacient crònic complex
Introduction: In the current socioeconomic context, addressing chronic diseases forces us to seek new, more efficient, strategies for complex chronic patients care. Family care can improve complex chronic patient management, ...
Statistical methods to manage and analyse real world data. Development of a health observatory in Alt Empordà
The objective of this thesis is to explore in greater depth the process of creating a public health observatory and the processing of the information needed to take territorial decisions in the county of Alt Empordà. The ...
