Departament de Ciències Mèdiques: Recent submissions
Now showing items 1-20 of 102
Study of endothelial dysfunction in chronic thromboembolic pulmonary hypertension and in COVID-19. Biomarkers and new targeted therapeutic strategies
The endothelium, the lining of our blood vessels, plays a crucial role in controlling functions such as blood flow, clotting and inflammation. When it does not function properly, called endothelial dysfunction, it can lead ...
Exploration into non-traditional risk factors of subclinical atherosclerosis in low-risk adults
Background: Atherosclerotic cardiovascular disease (ASCVD) manifests silently as subclinical atherosclerosis before a clinical event. Disparities in ASCVD risk, particularly among underrepresented ethnic and racial groups, ...
The flavonolignan silibinin in non-small cell lung cancer: molecular mechanisms and therapeutic relevance
Non-small cell lung cancer (NSCLC) is a challenging disease to treat. Despite several decades of improved clinical progress, there is an unmet need to investigate how therapeutic resistance develops. In particular, managing ...
Polimorfismos de los genes moduladores de la respuesta inmune como predictores de recaída en los pacientes con mieloma múltiple
Multiple myeloma (MM) remains an incurable disease despite the incorporation of new therapies. The natural history of disease is of the relapse following treatments due to the re-emergence of the tumour from residual disease ...
Síndrome de l’espai gluti profund (deep gluteal syndrome). Bases anatòmiques de la seva fisiopatologia i indicacions quirúrgiques
Pain in the buttock region without lumbar pathology will lead us to focus the study on the region of the subgluteal space. This is defined as the deep gluteal syndrome. The deep gluteal syndrome is a condition with a very ...
Complicacions perioperatòries de l’adrenalectomia laparoscòpica. Experiència a la província de Girona
INTRODUCTION: Adrenal masses are one of the most common tumors, being incidentally diagnosed in 5% of patients undergoing imaging tests. Until the beginning of the 1990s, all adrenal surgical treatment was performed through ...
El nivell i la variació del risc cardiovascular en la prevenció primària de la demència
Dementia causes progressive cognitive impairment and inability to lead an independent life. Currently, there is no curative treatment for it, and thus primary prevention is essential. Age is the main risk factor for ...
Predicción del riesgo cardiovascular en población de 75 o más años del Mediterráneo
The increase of elderly population in Spain is one of the most important challenges for their caregivers, healthcare professionals, and the society in general. The elderly population has the highest incidence rate of ...
Relació de la proteïna C-reactiva, el quocient neutròfils/limfòcits i l’adiponectina d’alt pes molecular amb paràmetres d’obesitat i de risc cardiometabòlic en nens prepuberals sans. Efecte modulador dels estils de vida
Childhood obesity is one of the most important public health problems and is associated with cardiometabolic risk factors (CMR). Low-grade inflammation plays a prominent role in the development of cardiometabolic alterations ...
Posible rol de las neuregulinas en la fisiología del tejido adiposo en asociación con obesidad y diabetes mellitus tipo 2
Different studies link the metabolic alterations of obesity with imbalances in neuregulin 4 levels. In this study we hypothesize that signaling of neuregulin isoforms (NRG) produced through ERBB receptors in human adipose ...
Methylome profiling of B and T cells along multiple sclerosis disease progression: a pilot study
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune and neurodegenerative disease characterized by the infiltration of autoreactive immune cells into the central nervous system that leads to axonal damage, ...
L’extracte de fulla d’olivera redueix la pressió arterial de pacients amb hipertensió arterial lleugera sense malaltia vascular subclínica
Introduction: Hypertension is the common cardiovascular risk factor and affects 20 to 50% of the population. Treatment, with drugs or not, involves improving lifestyle. Olive leaf extract has traditionally been taken to ...
Study of two analogues of pituitary adenylate cyclase-activating polypeptide as novel therapeutic compounds for Huntington’s disease
Huntington’s disease (HD) is a neurodegenerative genetic disorder with no effective treatment characterized by motor discoordination, deficits in cognitive function (acquiring new knowledges, memory, understanding…), and ...
Estudi de l’alliberació del calci intracel·lular en cardiomiòcits derivats de iPSC de pacients amb taquicàrdia ventricular polimòrfica catecolaminèrgica (CPVT)
In a small region of the island of Gran Canaria, 11 cases of sudden cardiac death (SCD) were registered in emotional or physical stress situations in young individuals between 1994 and 2007 in four seemingly unrelated ...
New approaches for the study and treatment of aggressive cancers
Although there are therapies for triple negative breast cancer (TNBC) and epidermal growth factor-mutated non-small cell lung cancer (EGFRm NSCLC), these two subtypes of cancer are very aggressive, and most patients develop ...
Estudio de la regulación génica en el locus SCN5A-SCN10A y su implicación en la etiología del Síndrome de Brugada
Brugada syndrome (SBr) is a cardiac electrical disease associated with a high susceptibility to ventricular arrhythmias and sudden cardiac death. Genetic variants in the coding regions of the SCN5A gene, which encodes for ...
Clinical epidemiology and molecular biology of cutaneous and mucosal melanoma in Girona 1994-2018
In this doctoral thesis, the epidemiology of cutaneous and mucosal melanoma is analyzed, as well as its molecular profile to provide new knowledge on a population basis in the province of Girona. The cancer registry of ...
Nova metodologia d’anàlisi de distribucions de dosi per algorismes de càlcul de dosi absorbida en radioteràpia externa que simulen el transport de radiació en medi
Introduction Different types of dose calculation algorithms for external beam radiation therapy with MV photons coexist nowadays. The oldest ones are convolution/superposition (C/S), which consider all media as water of ...
Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada
Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...
Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent
INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...
