Departament de Ciències Mèdiques: Recent submissions
Now showing items 26-45 of 97
Cognitive function in obesity: interactions with the gut microbiome
Obesity is considered a modifiable risk factor for cognitive impairment which, in turn, predisposes to overeating and weight gain. Compelling evidence in animal models has demonstrated the impact of the gut microbiome on ...
Cribratge i diagnòstic de la malaltia renal crònica en població adulta menor de 65 anys d’edat, de risc elevat, en l’àmbit de l’atenció primària de salut
Chronic kidney disease is due to different causes and its recognition is important for its association with an increased cardiovascular risk. This risk is increased in association with chronic conditions such as high blood ...
Biomarcadors pronòstics de ressonància magnètica en pacients amb glioblastoma de diagnòstic recent
Magnetic resonance imaging (MRI) is essential in the management of patients with glioblastoma, providing useful information for diagnosis, prognosis, and therapeutic planning. Although some presurgical and postsurgical ...
Grape stalk and coffee polyphenolic extracts administration as new pharmacological strategies to modulate spinal cord injury-induced neuropathic pain in mice
More than half of spinal cord injury patients develop central neuropathic pain, which is largely refractory to current treatments. Developing neuropathic pain has a high impact on the quality of life becoming an emotional, ...
Impacte clínic del càlcul de la dosi absorbida en radioteràpia externa mitjançant un nou algorisme basat en la solució de l'equació de Boltzmann
The algorithm for calculating absorbed dose in external radiotherapy Acuros XB (AXB), based on the solution of the Boltzmann equation, has shown to achieve a higher level of accuracy than the preceding convolution/superposition ...
Desenvolupament i beneficis per a la salut d'una aplicació mòbil basada en els problemes pediàtrics no urgents
The lack of knowledge and skills in the care of infants in their first years of life often results in frequent paediatric consultations for banal problems and doubts, which are often a result of a low level of health ...
Design and fabrication of three-dimensional scaffolds for breast cancer stem cell expansion and molecular characterization
Triple negative breast cancer (TNBC) accounts for 15-20% of the breast cancers and displays an aggressive profile, poor prognosis, high relapse risk and does not have a targeted therapy. In the last years, breast cancer ...
Monitoratge de la malaltia inflamatòria intestinal en la pràctica clínica mitjançant marcadors de la microbiota intestinal en mostres fecals. Estudi prospectiu
The gut microbiota (GM) plays a pivotal role in the maintenance of gut homeostasis, and the pathogenesis of inflammatory bowel disease (IBD) which includes Crohn's disease (CD) and ulcerative colitis (UC). The degree of ...
Programa d'intervenció familiar multidisciplinar en atenció primària de salut basat en la teràpia de resolució de problemes per la disminució de la utilització dels recursos sanitaris del pacient crònic complex
Introduction: In the current socioeconomic context, addressing chronic diseases forces us to seek new, more efficient, strategies for complex chronic patients care. Family care can improve complex chronic patient management, ...
Statistical methods to manage and analyse real world data. Development of a health observatory in Alt Empordà
The objective of this thesis is to explore in greater depth the process of creating a public health observatory and the processing of the information needed to take territorial decisions in the county of Alt Empordà. The ...
Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...
Effect of sodium channel SNVs associated to arrhythmogenic diseases. Modulatory role of the genetic background
Ion channel mutations can cause defects on the electrical cellular activity, leading to arrhythmogenic diseases also known as channelopathies. Genetic analysis has been a useful tool to identify these mutations as the cause ...
Osteotomia percutània distal del primer metatarsià per a la correcció de l’hàl·lux valgus. Estudi experimental comparatiu de dues tècniques quirúrgiques
Hallux valgus is a frequent deformity of the first ray of the foot, with progressive abduction and pronation of the first phalanx. At the same time, adduction, elevation, and pronation of the first metatarsal happens ...
The relevance of hydrogen sulfide (H2S) in obesity and adipose tissue physiology
Hydrogen sulfide (H2S), regarded as the third gasotransmitter, plays diverse physiological and pathological roles in the body along with another two gasotransmitters, including nitric oxide (NO) and carbon monoxide (CO). ...
Fatty acid synthase expression and inhibition in cancer
In this thesis,the association of FASN (fatty acid synthase) expression with clinicopathological and anthropometric characteristics in breast cancer patients is studied to find out FASN role as a prognostic in early stage ...
Relevance of the epigenetic regulation exercised by hepatic microRNAs in the fatty liver arena: from the bedside to the bench
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, involving a spectrum of disturbances mainly characterized by fatty acid infiltration and fat deposition in the liver ...
Indicació selectiva de "shunt" en l'endoarteriectomia carotídia, un nou mètode
The protocol followed in this thesis is to indicate the EAC according to the NASCET criteria. Closure of the arteriotomy with patch. The criteria to indicate this have been based on an original method, which takes into ...
Trafficking and function of the voltage-gated sodium channel β2 subunit
The sodium channel β2 subunit is a component of the voltage-gated sodium channel (NaV), a large multimeric protein complex. In the heart, NaV is mainly composed of a pore-forming α subunit, NaV1.5, and two associated ...
Estudi epidemiològic poblacional de la incidència, tendència i supervivència de les neoplàsies limfoides a la província de Girona durant un període de 20 anys (1996-2015)
The incidence, time trends and survival of lymphoid neoplasm’s in the Girona province are analyzed from 1996 to 2015. The survival of diffuse large B-cell lymphoma (LBDCG) before and after 2004 and estimate incidence rate ...
Avaluació de la funció renal en la millora de la predicció del risc vascular. Anàlisi del rol de les estatines en la prevenció primària d’esdeveniments cardiovasculars en la població amb malaltia renal crònica inicial
Cardiovascular diseases are the leading cause of mortality and morbidity worldwide as well as in our population. One of the main cardiovascular prevention strategies is to identify healthy patients who are at risk of ...
