Universitat de Barcelona
Mostrando ítems 182-201 de 229
Neurofibromatosis type 2 (NF2) is an autosomal dominant condition caused by loss of function variants in the NF2 gene. The pathognomonic feature of the disease is the development of bilateral vestibular schwannomas (VS), ...
The perpetuation of life depends on the ability to reproduce. All known forms of life use DNA as genetic information storage. Ribonucleotide reduction is the process by which ribonucleotides (NTPs) are transformed into ...
Many chemicals are continuously entering into the aquatic environment, as a result of their widespread use, disposal and accidental release. Several of these xenobiotics may disrupt reproductive functions of both vertebrates ...
Las proteínas insulator son componentes esenciales de la organización tridimensional de la cromatina ya que son capaces de establecer interacciones entre regiones distantes de la mediante su capacidad de asociarse a otras ...
The role of consumer-resource relationship is the basis of the structure and functioning of ecological communities. The traditional lens for studying such interactions have tended to omit the importance of the species ...
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, Cic is expressed as ...
Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...
Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. Slow-cycling cancer ...
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...
The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them preventive treatments. ...
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several ...
[eng] The lungs are constantly exposed to external particles and microbes, so their particular immune environment is immunosuppressive to avoid unnecessary inflammatory responses. This increases the susceptibility of this ...
Tumors evolve by sequentially acquiring genetic abnormalities, like K-Ras activation and Tp53 loss of function, which enable transformed cells to survive, proliferate, invade, and reprogram their microenvironment. ...
In the eukaryotic cell nucleus, DNA is tightly wrapped around histone complexes, forming a dynamic structure known as chromatin. The nucleosome particle is the basic repeating unit of the chromatin fiber and its protein ...
Aiming to improve the conservation status of the European seas, the Marine Strategy Framework Directive (MSFD) was adopted in 2008, establishing a general framework for all EU countries in the field of marine environmental ...
The regulated secretory pathway is a hallmark of professional secretory cells as neurons and endocrine cells. Significant peptidergic neurotransmitters as hormones, neurotrophins and growth factors are targeted to ...
Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, show regenerative ...
[spa] El diagnóstico de enfermedades humanas originadas a causa de variantes y mutaciones en el ADN de cada persona está experimentando un cambio de paradigma, desde la aproximación genética tradicional hacia una que ...
SLIMP (Seryl-tRNA Synthetase-Like Insect Mitochondrial Protein) was identified during the generation of a mitochondrial human disease fly model. SLIMP was described as a previously uncharacterized paralog of the Drosophila ...
Cell fate is controlled by a multitude of signals and loss of this control has devastating consequences for living organisms. One of the key players in this network of signals is the TGF-beta family of cytokines. These ...
