Departament de Bioquímica i Biomedicina Molecular: Enviaments recents
Ara mostrant els elements 1-20 de 68
TP53INP2 at the crossroad of transcription, autophagy and liver metabolism
[eng] Metabolic-associated steatotic liver disease (MASLD) is the leading global liver chronic disease and it is estimated to affect 30% of the world population. MASLD is a progressive multi-stage disease characterized by ...
Targeting metabolic reprogramming in metastatic colorectal and prostate cancer cells to prevent therapeutic failure
[eng] Prostate and colorectal cancer are among the cancer types with the highest recurrence and mortality rates. The emergence of drug resistance poses a considerable challenge for effective treatment, especially in the ...
Analysis of consensus motions in proteins through molecular dynamics simulations
[eng] The understanding of proteins as dynamical entities rather than static structures marked a very significant advance in the interpretation of their functional role in life. The capacity of proteins to interact with ...
Estudio de la interacción de hCNT3 y QDPR como nexo funcional entre la recuperación de nucleósidos y sus vías biosintéticas
[spa] Aún queda mucho por conocer sobre la regulación de la función de los transportadores concentrativos de nucleósidos hCNTs. A pesar de que se expresan en muchos tipos de tejidos, su localización no es ubicua y varía ...
Regulatory subunits controlling the Kv1.3 channelosome
[eng] The Kv1.3 voltage-dependent potassium channel plays a crucial role in the immune response participating in various cellular functions like proliferation, activation, and apoptosis. The aberrant expression of this ...
Network-based methods for biological data integration in precision medicine
[eng] The vast and continuously increasing volume of available biomedical data produced during the last decades opens new opportunities for large-scale modeling of disease biology, facilitating a more comprehensive and ...
Expresión y Funcionalidad de Receptores de Cannabinoides y de Adenosina y de sus Heterómeros en modelos de Alzheimer y de Esclerosis Múltiple
[eng] Adenosine and endocannabinoids are regulatory molecules that are present in all organ and physiological systems. They act via specific receptors belonging to the G protein-coupled receptor (GPCR) superfamily. There ...
Involvement of Alternative Splicing Regulation in Adipose Tissue Thermogenic Induction
[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism is tightly regulated ...
Development and application of methodologies and infrastructures for cancer genome analysis within Personalized Medicine
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to ...
Noves evidències de l’efecte neuroprotector del Sistema Cannabinoide a nivell del Sistema Nerviós Central
[cat] El Sistema Cannabinoide, que inclou els dos receptors de cannabinoides CB1 i CB2, els seus lligands endògens i els enzims de síntesi i degradació d’aquests, és un sistema molt complex que controla un gran nombre de ...
Protein kinase-dependent Kv1.3 biology
[eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes. This channel presents a wide distribution ...
Regulation of hepatic metabolism by the autophagic protein TP53INP2
[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in our daily behavior ...
Obesitat severa i ateroesclerosi subclínica: biologia molecular, marcadors i efecte de la cirurgia bariàtrica
[cat] La predicció del risc de patir un esdeveniment cardiovascular en les persones amb obesitat severa és imprecisa. A més, els mecanismes que interrelacionen l’obesitat amb l’ateroesclerosi no es coneixen amb suficient ...
Parmbsc2: Development of an accurate force field for nucleic acids simulations
Molecular dynamics (MD) simulations are the equivalent to a computational microscope allowing us to interrogate molecules and their behaviour in complex systems. They are recognised as a valuable and accurate tool in ...
Obtención de aptámeros específicos para enzimas de la vía del metileritritol fosfato de microorganismos
FUNDAMENTO: Microorganismos patógenos como las bacterias Mycobacterium tuberculosis y Pseudomonas aeruginosa, y los protozoos del filo Apicomplexa, incluyendo los agentes causantes de la malaria y la toxoplasmosis, sintetizan ...
Characterization of the role of TKTL1 in Acute Monocytic Leukaemia
Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis stratification. ...
Molecular determinants of the Kv1.3/KCNE4 interaction
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...
Mitochondrial dynamics as a hub in the control of muscle inflammation
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this activation is ...
Paper dels factors neuronals SEMA3F i NTN1 en la transició de càncer de mama in situ a invasiu
La teoria més plausible de l’evolució del càncer de mama és la que considera el carcinoma ductal in situ (DCIS) com a precursor no obligat del carcinoma ductal invasiu (IDC), que eventualment progressa cap a l’etapa ...
Papel de las cardiocinas FGF21 y Metrnl en la hipertrofia cardíaca
El objetivo principal de esta tesis fue el estudio de la función de dos nuevas cardiocinas, FGF21 y Metrnl, durante el desarrollo de la patología cardíaca. Se dividió en los siguientes apartados: PARTE 1: Caracterización ...
