Facultat de Medicina i Ciències de la Salut: Envíos recientes
Mostrando ítems 61-80 de 622
Característiques distintives del Test de Latències de Son Múltiples (MSLT) en la narcolèpsia
[cat] Aquesta Tesi Doctoral es presenta en format compendi d’articles, que corresponen a la mateixa unitat temàtica: l’estudi de trets distintius de la narcolèpsia en el Test de Latències de Son Múltiples (MSLT). En aquesta ...
Caracterización citogenético-molecular de la leucemia linfocítica crónica con cariotipo complejo. Identificación de subgrupos con relevancia clínica
[spa] La complejidad genómica, detectada por citogenética convencional (CC) en forma de cariotipos complejos (CK) o por microarrays genómicos (MG), incluyendo los patrones de cromotripsis, se ha asociado a un curso clínico ...
Oral health in long-term space missions: previous experience, prevention and treatment needs
[eng] This doctoral thesis is the result of a four-year research project aimed at establishing whether dentistry is relevant to the space race, and whether, consequently, the creation of a scalable dental module capable ...
Estudio de la función inmunomoduladora de co-receptores linfocitarios tipo scavenger
[spa] INTRODUCCIÓN: Los receptores linfocitarios tipo scavenger CD5 y CD6, son moléculas de transmembrana que funcional y estructuralmente pertenecen a la superfamilia de receptores de la inmunidad innata. CD5 y CD6 se ...
Expresión de CD20 en linfocitos T con un receptor antigénico quimérico anti-CD19 para su selección o eliminación
[spa] Varias inmunoterapias tumorales han demostrado ser altamente eficientes, como es el caso de los ya incuestionables resultados obtenidos con la terapia de células T que expresen receptores frente a antígeno quiméricos ...
CHEMSEX: Caracterización de usuarios de drogas en contexto sexual y su asociación con VIH, VHC y otras enfermedades de transmisión sexual
[spa] Desde el descubrimiento del VIH/SIDA y el inicio de la epidemia en la década de los años ochenta, esta enfermedad ha afectado a grupos que viven en condiciones de vulnerabilidad. Los primeros casos fueron descritos ...
Isolation, Culture and Characterization of Klinefelter Spermatogonial Stem Cells
[eng] INTRODUCTION: Klinefelter syndrome (KS) is a chromosomal abnormality that affects approximately 1 in 500-1000 male births. Their most frequent karyotype is 47XXY and up to 10% of them present significant mosaicism ...
Biochemical and mechanical changes of the extracellular matrix during lung metastasis
[eng] The mechanical properties of a tumor play an important role in cancer progression and therapeutic response. In fact, the stiffening of the tumor microenvironment has been linked to therapy resistance and an increased ...
Study of the effects of mechanical force on nucleo-cytoplasmic transport
[eng] Mechanical force controls fundamental cellular processes in both healthy and diseased cells, and more and more evidence shows that the nucleus experiences and feels the forces applied to it. These forces can lead to ...
Understanding the genotype-phenotype relation between PIK3CA variant signalling and vascular malformations
[eng] Vascular malformations (VMs) represent a diverse group of diseases with complex yet poorly understood underlying mechanisms. Causative gain-of-function mutations in PIK3CA have been associated with the onset of these ...
Exploring the use of tolerogenic dendritic cells and pore-forming toxins in the context of oncolytic adenoviruses
[eng] Oncolytic viruses (OVs), engineered to infect preferentially and selectively replicate within cancer cells while sparing healthy tissues, have regained interest in oncology for their potential to restore host anti-tumor ...
Characterization of the Immune System, Hematopoietic Stem Cells, and Molecular Biomarkers in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: Implications for Improved Stratification and Treatment.
[eng] INTRODUCTION: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are clonal hematological neoplasms characterized by ineffective hematopoiesis, chronic inflammation and complex molecular ...
Study of the acquisition and maintenance of antibody and cellular immune responses against SARS-CoV-2 in longitudinal cohorts
[eng] The COVID-19 pandemic has underscored the importance of understanding adaptive immune responses to SARS-CoV-2 to optimize vaccination strategies and public health interventions. Adaptive immune responses generate ...
Avances en la Caracterización del Sustrato Arrítmico y Procedimientos de Ablación: Integración de Catéteres de Alta Densidad y Nuevas Aplicaciones de Resonancia Magnética Cardíaca
[spa] Las arritmias ventriculares en pacientes con cardiopatía estructural son una de las principales causas de muerte y morbilidad en dicha población. Su origen se haya en cicatrices miocárdicas que pueden ser identificadas ...
Development of a brain-penetrant formulation of SN-38 using shuttle peptides for the treatment of pediatric high-grade gliomas
[eng] Drug delivery to the brain remains a significant challenge due to the integrity of the blood-brain barrier (BBB), which protects the brain tissue. In this study, we present the design and preclinical development of ...
Prevalence of unexpected positive intraoperative cultures in hip arthroplasty and their impact on the result and survival of the prosthesis
[eng] INTRODUCTION: Total hip arthroplasty (TKA) is performed more and more frequently due to the increase in indications and longer life expectancy. Approximately 12% will require revision surgery at 10-15 years, with ...
Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
[eng] INTRODUCTION: The introduction of new drugs such as sacubitril/valsartan and empagliflozin has markedly improved clinical outcomes in patients with heart failure (HF). The role of these drugs in HF is well-established; ...
Estudio anatómico y ecográfico del nervio radial en su recorrido por el brazo y antebrazo
[spa] El nervio radial realiza un tortuoso camino por el brazo y antebrazo relacionándose con diferentes estructuras anatómicas que están envueltas por la fascia muscular profunda de la extremidad superior (EESS) y más ...
Unravelling Neural Heterogeneity in Mental Disorders: The Role of Genetics, Cognition, and Comorbidities
[eng] INTRODUCTION: Mental disorders are one of the main causes of disability worldwide, with a significant impact on the quality of life of those affected and a great economic and social burden on society. Despite advances ...
Implementación de un sistema de dosimetría in vivo mediante detectores de centelleo plástico en braquiterapia
[spa]INTRODUCCIÓN: La braquiterapia (BQT) es una forma de radioterapia que utiliza fuentes radiactivas encapsuladas para administrar tratamientos a corta distancia. Esta técnica permite una alta dosis de radiación en ...
