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Facultat de Medicina i Ciències de la Salut: Recent submissions

Now showing items 21-40 of 556

    Modulating Immune Cell Fate and Inflammation through CRISPR-mediated DNA Methylation Editing 

    Valcárcel Ximenis, Gemma (Date of defense: 2025-01-21)

    [eng] Immune cell differentiation and activation are associated with widespread DNA methylation changes; however, the causal relationship between these changes and their impact in shaping cell fate decisions still needs ...

    Unraveling injury and repair mechanisms in alcohol-associated liver disease: From neutrophils to organoid-based modeling 

    Ariño Mons, Silvia (Date of defense: 2025-01-16)

    [eng] Alcohol-associated liver disease (ALD) is one of the leading causes of disability and premature mortality worldwide, with few therapeutic treatments. Therefore, it is important to understand the underlying mechanisms ...

    Caracterización epidemiológica, clínica e inmunológica del Síndrome Inflamatorio Multisistémico Pediátrico asociado a la infección por SARS-CoV-2 

    Pino Ramírez, Rosa Mª (Date of defense: 2025-01-15)

    [spa] La infección por el nuevo coronavirus SARS-CoV-2, iniciada en Wuhan, emerge y se propaga rápidamente constituyéndose pronto como pandemia. La infección muchas veces asintomática, produce en pacientes una enfermedad ...

    Role of prefrontal monoamines in a novel translational test of working memory for rodents 

    Gamallo Lana, Begoña (Date of defense: 2025-01-10)

    [eng] In this thesis I have several stepwise and interrelated hypotheses: Rodent Self-Ordered Working Memory (rSOWM) paradigm 1) Increasing the number of response options in the novel rSOWM task in rats will increase ...

    Novel cell models for the identification of biomarkers and therapeutic targets in Inclusion Body Miositis 

    Cantó Santos, Judith (Date of defense: 2023-10-16)

    [eng] INTRODUCTION: Inclusion body myositis (IBM) is a rare inflammatory disease that affects the proximal and distal muscles and causes muscle weakness progressively. It begins from the age of 50 and the first symptoms ...

    Epic Battles in Myeloma: Deciphering the Role of PVR in the Fight Between Tumors and Cytotoxic Cells 

    Martinez Verbo, Laura (Date of defense: 2024-12-20)

    [eng] HYPOTHESIS: Epigenetics influence cancer and recently epigenetic plasticity has been included as a new hallmark of cancer described in the latest published work of Hanahan113. Growing scientific evidence has pointed ...

    The pulleys: from the anatomical and histological basis to sonoanatomical characterization 

    Coronel Tarancón, Luis (Date of defense: 2024-12-20)

    [eng] INTRODUCTION: Digital annular pulleys (DAP) are important anatomical structures for finger function. The anatomy, histology and imaging assessment of DAP, particularly at the level of their entheses, has not been ...

    Uncovering TET2 chromatin targets at the leukemic onset 

    Lazarenkov, Aleksey (Date of defense: 2024-12-18)

    [eng] Epigenetic modifications, including DNA methylation, have been shown to play a prominent role in influencing cell identity in hematopoiesis. However, its role in gene regulation during differentiation remains poorly ...

    Factores Psicológicos Asociados al Desarrollo y Curso de las Adicciones Comportamentales o Adicciones sin Sustancia 

    (Date of defense: 2024-12-19)

    [spa] INTRODUCCIÓN: Existe un debate epistemológico centrado en determinar cuál es el enfoque diagnóstico más adecuado en el campo de la salud mental, enfrentando modelo categorial frente al dimensional. El categorial ...

    Psiquiatría nutricional aplicada al trastorno bipolar 

    Costa, Susana Patrícia Gomes da (Date of defense: 2024-12-18)

    [spa] INTRODUCCIÓN: El trastorno bipolar (TB) es un trastorno crónico del estado de ánimo caracterizado por fluctuaciones del estado de ánimo, que afecta a un amplio rango de población y se relaciona con un importante ...

    Valoración de la reserva ovárica. Estudio de parámetros hormonales y ecográficos 

    Peralta Flores, Sara (Date of defense: 2024-12-17)

    [spa] INTRODUCCIÓN: Los marcadores de reserva ovárica son excelentes predictores de respuesta ovárica, pronóstico y riesgo de complicaciones en FIV/ICSI, aunque no son predictores de fertilidad natural. La determinación ...

    Advancing precision medicine in cancer and COVID-19 with bioinformatics: a multifaceted affair 

    García Prieto, Carlos Antonio (Date of defense: 2024-12-14)

    [eng] Advancing precision medicine requires integrating bioinformatics to unravel complex biological data and translate these insights into clinical applications. This thesis explores the role of bioinformatics in enhancing ...

    Sleep disorders in immune-mediated synaptic encephalopathies 

    Muñoz Lopetegi, Amaia (Date of defense: 2024-12-17)

    [eng] INTRODUCTION: Autoimmune encephalitis (AEI) is an inflammatory disease of the central nervous system, caused by specific antibodies against synaptic or neural surface proteins. More than twenty have been described ...

    Unveiling the role of the Mediator complex in Ewing sarcoma tumorigenesis 

    Cuervas Oliveras, Irene (Date of defense: 2024-12-17)

    [eng] Ewing sarcoma is an aggressive tumor arising in bones and soft tissues that affects children and young adults. This disease is determined by an aberrant chromosomal translocation that forms an oncogenic fusion protein, ...

    Eficacia y seguridad de las nuevas técnicas de resección endoscópica para neoplasias precoces gastrointestinales 

    Uchima Koecklin, Hugo Ikuo (Date of defense: 2024-12-17)

    [spa] INTRODUCCIÓN: La detección y caracterización endoscópica de lesiones neoplásicas precoces (lesiones superficiales confinadas a la mucosa o submucosa que en casos seleccionados tienen un riesgo muy bajo de metástasis ...

    IKKα modulates metastatic activity by preventing Tight Junctions stabilization and collective cell migration 

    Alvarez Villanueva, Daniel (Date of defense: 2024-12-16)

    [eng] The IKKα kinase was previously found to activate multiple oncogenic and therapy-resistance pathways, including ATM/DDR, BRD4, and JAK/STAT3, independently of canonical NF-KB signaling. Here, we show that suppression ...

    New therapeutic approaches to target myofibroblast activation in liver pathologies: fibrosis and cholangiocarcinoma 

    Amengual Segura, Josep (Date of defense: 2024-12-16)

    [eng] HYPOTHESES: Iron accumulation and senescence mediate fibrosis progression in kidney and lung. In the liver, iron overload, specifically in hepatocytes, has been linked to hepatic diseases such as hereditary ...

    Diagnóstico de la causa de muerte y caracterización de infecciones fatales en muestras post mortem en países de baja renta 

    Hurtado Negreiros, Juan Carlos (Date of defense: 2024-12-13)

    [spa] INTRODUCCIÓN: La ausencia de datos confiables sobre las causas de muerte se ha señalado como un factor limitante para reducir la mortalidad en el mundo. Entendemos que para poder desarrollar un planteamiento y ...

    Understanding Adiposity through Body Shape Phenotypes: Implications for Cancer Risk, Inflammation, and Prediction 

    Peruchet Noray, Laia (Date of defense: 2024-12-13)

    [eng] INTRODUCTION. Obesity is characterized by excess body fat (adiposity) and is a major determinant of disability. Obesity is mainly measured by body mass index (BMI) although it presents several limitations. For instance, ...

    Unraveling the molecular basis of the metastatic process in Ewing sarcoma: insights into the role of LOXHD1 and PARP14 

    Sánchez Serra, Sara (Date of defense: 2024-12-13)

    [eng] HYPOTHESIS AND OBJECTIVES 1. Hypothesis: Metastasis is the worst prognostic factor in EwS patients, dropping patients’ overall survival to less than 30 %43. Further, about 25 % of patients present with metastatic ...