Programa de Doctorat en Biomedicina: Recent submissions
Now showing items 101-120 of 1445
A New in vitro model to study the regulatory functions of β cells in early stages of type1 diabetes
Type 1 Diabetes (T1D) is an autoimmune disease marked by the selective destruction of pancreatic β cells. Early insulitis involves interactions between immune cells and β cells, but the mechanisms leading to β cell death ...
Quantifying cellular behavior during early mammalian development
In this thesis we study cell behaviours such as cellular decision making and self-organization using the developing mouse embryo as the system of study. To be able to extract the most needed cellular dynamics from ...
Interrogating the importance of x-chromosome inactivation and reactivation for meiotic potential
X-chromosome dosage compensation in female mammals is achieved through X-chromosome inactivation (XCI), where one X chromosome is epigenetically silenced to ensure dosage parity with male cells. During germline development, ...
Deciphering lymphoma-specific DNA methylation alterations in healthy B cells: a single-cell multiomics study
Recent studies have shown that clones harboring cancer driver mutations colonize our tissues as we age. It remains to be determined whether the same is true for epigenetic alterations, specifically DNA methylation (DNAm) ...
Dissecting motor behaviour alterations in Parkinson's disease using genetically modified zebrafish models
Los trastornos neurodegenerativos como la enfermedad de Parkinson (EP) implican la degeneración progresiva del sistema nervioso, lo que provoca alteraciones tanto motoras como cognitivas. La EP afecta a millones de personas ...
Decoding the regulatory grammar of hematopoiesis using synthetic enhancers
During cellular differentiation, gene regulatory elements (GREs) play a crucial role in converting expression gradients of transcription factors (TF) into precise target gene activation. However, the underlying rules are ...
Novel transcription mechanisms used by dendritic cells in the tumor immune microenvironment
Interferon is essential for eliciting adaptive immunity against cancer cells. Type I interferon (IFNI) activates proinflammatory responses in dendritic cells (DCs) and this promotes specific anti-tumor T cell responses. ...
Equivariant graph neural networks in drug discover: from property prediction to molecule generation
Advancements in machine learning have revolutionized various aspects of drug discovery, from molecular property prediction to de novo design. This thesis presents a comprehensive exploration of equivariant graph neural ...
When P. falciparum meets the brain microvasculature: a 3D blood-brain barrier model to study cerebral malaria
La alteración de la barrera hematoencefálica está relacionada con la malaria cerebral, una complicación de la infección por Plasmodium falciparum asociada con la acumulación del parásito en los vasos sanguíneos cerebrales. ...
Machine learning methods of property prediction in drug discovery
Molecular properties are highly important in drug discovery with binding affinity being crucial for selecting hit and lead candidates. Existing machine learning models often lack speed for large-scale screening or lack ...
CEBPa is an orchestrator of trophectoderm specification
La bifurcación entre trofoectodermo y la masa celular interna es la decisión de desarrollo más temprana, pero cómo se inicia y en qué etapa embrionaria ocurre no se entiende completamente. Aquí describimos que el factor ...
Synaptic transcriptomic changes sensitive to pharmacological approaches in fragile X syndrome: from mouse to human
Fragile X syndrome (FXS), the most common monogenic cause of intellectual disability and autism, is characterized by impairment in cognitive function and synaptic plasticity. Several preclinical studies in animal models ...
Evaluation of tumor mutational burden in follicular lymphoma
El linfoma folicular (LF) es el subtipo más frecuente de linfoma no-Hodgkin indolente, caracterizado por un buen pronóstico a pesar de considerarse incurable. Sin embargo, algunos pacientes presentan un curso clínico más ...
Fixing a broken heart: Zebrafish as a model for heart regeneration drug discovery
Myocardial infarction (MI) remains a leading cause of mortality, with currently available treatments addressing symptoms rather than promoting heart muscle regeneration. Cardiac regeneration strategies, inspired by ...
Genomic analysis of demographic changes in Southern Europe during Roman colonization and Late Antiquity
The expansion of the Roman Empire throughout the Mediterranean region and West Eurasia severely shaped the world culturally and politically. This period has been traditionally studied and researched by historians and ...
Temperature impacts on mortality at different spatial and temporal scales
This PhD thesis investigates the relationship between temperature and mortality at different spatial and temporal scales, addressing a crucial issue in the context of rising temperatures due to anthropogenic climate change. ...
Phylogenetic applications of ancient protein sequences
The resilience of proteins against degradation makes them the longest surviving resource for genomic information. Knowing how much information we can obtain from an ancient sample is crucial because most sampling strategies ...
Analyzing the role of cancer-associated adipocytes in brest tumor metastasis
In breast cancer, the tumor microenvironment includes adipocytes and fibroblasts. When in contact with breast tumor cells, adipocytes undergo lipolysis and dedifferentiation. This thesis demonstrates that cancer-associated ...
Al modelling of real-world patients: applications in prostate cancer
This thesis investigates the integration and analysis of OMICs data to enhance in silico modelling of real-world patients, with a special focus on prostate cancer. By leveraging publicly available transcriptomics data, ...
Urban heat islands and nature-based solutions: insights into health impacts and urban planning determinants
The current and projected rapid urbanization rates underscore the critical role of cities and the urgent need to prioritize the development of healthy and sustainable urban environments. Rising temperatures, intensified ...
