Programa de Doctorat en Biomedicina: Recent submissions
Now showing items 21-40 of 1335
Investigating protein functions of understudied genes, proteoforms and novel localisations
The eukaryotic protein landscape, although extensively studied, still harbors a vast array of uncharacterized functional proteoforms that limit our understanding of biological processes. This thesis explores three aspects: ...
Design and implementation of a next-generation sequencing test for the fast and cost-effective SARS-CoV-2 differantial diagnosis and variant detection
In the beginning of 2020 the WHO declared a pandemic that was initiated by the outbreak of a new virus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that quickly spread globally, challenging our ...
Medical nanotechnology applications in regulatory science: strategic policy development for the regulatory assessment of nanotechnology-enabled health products
Nanotechnology promises to revolutionize healthcare, but complex regulations slow its market introduction. This thesis examines the gap between nanomedicine research and its commercialization, addressing the 'valley of ...
A 3D multi-modal approach to study neuronal differentiation and tissue growth in the zebrafish hindbrain
The process by which the diversity of neurons making up the brain are produced relies on precise adjustments across space and time. Proneural genes are main drivers of neurogenesis across the different areas of the brain ...
Brain resilience, vulnerability, and modifiable risk factors in populations at risk of Alzheimer's disease
This thesis explores early pathophysiological processes related to Alzheimer’s disease (AD) and their associations with modifiable factors in cognitively unimpaired, middle-aged individuals at risk of AD. Through five ...
CSDE1 isoforms in cancer progression and suppression
The RNA-binding protein CSDE1 is a key regulator of mRNA stability and translation, involved in a wide range of biological processes. Alterations of CSDE1 expression and/or genetic mutations have been found in neurode ...
Discovery and evolutionary analysis of novel genes and translated ORFs
This thesis analyzes the generation of new genes created de novo and evaluates their evolution mainly in yeast but also in flies. First of all, we used next generation sequencing technology to analyze both new sequences ...
The gastrulating zebrafish under heat waves and cold spells: developmental robustness and vulnerabilities under changing temperatures
Temperature affects all processes, including development, and yet, it remains unknown how and/or if underlying mechanical and biochemical events are coordinated to slow down development robustly at lower temperatures. Here, ...
Electrical conductivity of hepatic tissue and its manipulation by intraarterial infusion of glucose: preliminary in vivo experiences in rats and patients
This study explores the potential of irreversible electroporation (IRE) in the treatment of scattered liver tumors, focusing on the electrical properties of the tissue. The administration of a 5% glucose solution (GS5%) ...
Mapping protein-coding genomes to phenomes: a phylogenetic perspective
In the current genomics era, it is essential to understand how the existing genomics diversity across evolution is linked to the enormous diversity we observe at the phenotypic level. Until now, Genome-wide association ...
Characterisation of walking in older adults: chronic obstructive pulmonary disease (COPD) as a case study
Background: Walking is crucial for an active and healthy ageing. Aim: To understand walking in ageing populations, and, as a case study, in chronic obstructive pulmonary disease (COPD). Methods: This thesis (in seven ...
"Somitogenesis unbound": dissecting the spatiotemporal control of mammalian embryo segmentation through in vitro models of development
Stem cell-based in vitro systems have recently been used to complement the study of developmental processes in the embryo. Somitogenesis, which segments a vertebrate body axis to establish its characteristic body plan, ...
Exploring the pathogenesis of rare disorders: novel approaches from genomics to transcriptomics
Rare disorders have been presumed to be caused by monogenic variation for decades, hindering the diagnosis in some cases. With many rare disease patients still missing a molecular diagnosis after genetic testing, the ...
Systems biology perspectives on cellular senescence and inflammation
This thesis examines inflammation from the perspective of systems biology in two different situations: cellular senescence resulting from unresolved tissue damage and the acute immune response to the invasion of a pathogen, ...
Impacts of early-life vitamin D on child and adolescent health outcomes
Els baixos nivells de vitamina D durant l’embaràs i els primers anys de la vida són freqüents en dones embarassades i en nadons i, a més, poden tenir implicacions per a la salut de l’infant a llarg termini. Malgrat això, ...
Biological brain-age prediction using machine learning on neuroimaging data: links with pathophysiological mechanisms, dementia risk factors and cognitive decline
This thesis explores the links between neuroimaging-derived brain-age, which is computed using machine learning techniques, and different pathophysiological mechanisms, dementia risk factors and cognitive decline in ...
Exploring the genetic diversity of European ants and butterflies
Biodiversity encompasses the great variety of organisms that exist on Earth, as well as their genetic variation and the ecosystems of which they are part. In this thesis, two diverse and ecologically important groups are ...
Towards development of novel circular RNA-based antiviral therapies
Currently, there are no antiviral strategies to rapidly respond to novel emerging viruses or to mosquito borne viruses. On this thesis we have developed an innovative artificial circular RNA (circRNA) antiviral platform ...
Integrating computational techniques for enhanced understanding of protein-protein interactions and the human interactome
Protein-protein interactions (PPIs) are fundamental in driving biological processes and maintaining life’s diverse functions. They play a key role in cellular regulation, facilitating our understanding of both basic ...
OccRF-Health study: occupational exposure of workers to RF-EMF
Radiofrequency electromagnetic fields (RF-EMF) exposure, ubiquitous in our environment due to the rise in mobile phones and wireless technology, has grown significantly in the last 30 years. This exposure is generally ...
