Programa de Doctorat en Biomedicina: Recent submissions
Now showing items 41-60 of 1335
Untangling chromatin: investigating the role of transcription, supercoiling and topoisomerases in genome organization
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada en el interior ...
Role of histone modifications in transcription regulation upon environmental stress in eukaryotes
Epigenetic modification serves as a crucial mechanism in regulating gene expression and facilitating cellular adaptation to environmental stress. This study aimed to identify histone residues and their associated ...
Deciphering B lymphocyte dynamics in health and disease through the integrative analysis of multi-modal single-cell data
The intrinsic complexity and dynamic nature of B-lymphocytes make them ideal for in-depth analysis using single-cell technologies. Secondary lymphoid organs (SLOs) are central in B-lymphocyte activation and differentiation, ...
Modeling cell type evolution using single-cell and chromatin profiling approaches
Single-cell genomics methods have revolutionized the study of gene expression and regulation at the cell type level. Generating single-cell atlases for species at key phylogenetic positions of the animal tree of life (e.g.. ...
Health impacts and determinants of environmental exposures related to urban and transport planning practices in European cities
The rapid increase in urbanization underscores the need for healthy urban environments. Presently, European cities experience high levels of air pollution, noise, lack of green spaces, and increased local temperatures, all ...
Exploring the role of climate variability and change in the spillover of zoonotic diseases: towards the development of Early Warning Systems (RWS)
The primary goal of this PhD is to deepen our understanding and improve the modeling capacity of zoonotic spillover, the multilevel process by which pathogens manage to overcome a series of natural barriers and infect other ...
Experience-dependent information processing in biological systems
Organisms need to integrate its previous experience with its current internal state in order to deliver a suitable response to dynamic changes in their environment. This thesis is devoted to analyze, using a mathematical ...
The phenotypic plasticity behind the origin of animals: functional genomics, cell biology, and new genetic tools
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel the evolutionary ...
Hacia una medicina basada en la precisión en entornos de rehabilitación: evaluación del estado nutricional y la sarcopenia en pacientes con enfermedades crónicas = Towards a precision-based rehabilitation medicine: asssessment of nutritional status and sarcopenia in patients with chronic diseases referred to rehabilitation
Esta tesis aborda la malnutrición y la sarcopenia en pacientes con enfermedades crónicas, centrándose en la enfermedad pulmonar obstructiva crónica (EPOC) y la enfermedad renal crónica. Utilizando los criterios de la Global ...
Characterization of allosteric communication networks in GPCRs
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation in pharmacotherapy. ...
PET in preclinical AD: image harmonization, characterization of the centiloid metric of Aβ load and associations with tau fluid biomarkers
This thesis explores technical factors influencing brain PET quantification, developing brain PET harmonization framework, assessing Centiloid robustness as a clinical biomarker, and evaluating the associations between ...
Decoding the epitranscriptomic complexity through computational methods based on long-read sequencing
RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple biological processes, including splicing regulation, gene expression regulation and antibiotic resistance. Unfortunately, ...
Development of a low input chromatin profiling technique to examine the role of PRC2 proteins in development and leukaemia
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal translocations and ...
Influencias del entorno alimentario de los centros educativos sobre el peso de los escolares
Esta tesis tiene como objetivos evaluar el entorno alimentario alrededor de las escuelas de Barcelona en términos de proximidad y disponibilidad de establecimientos alimentarios y su relación con el nivel socioeconómico ...
Dinámica clonal en las neoplasias mieloproliferativas crónicas
Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones driver que afectan a la vía JAK/STAT. ...
Precise writing of human genomes: engineering & characterizing genome editors for programmable DNA integration in human cells
Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome editors has enabled ...
Neural entrainment to languages of different rhythms in adults and infants
In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. In two experimental ...
Analysis of circulating RNAs for the early detection of complex diseases using liquid biopsy
RNA is a molecule that is released by the different tissues into the circulation. When it is found in the circulation it is called cell-free RNA (cfRNA). This type of molecule has great potential as a noninvasive biomarker ...
Dissecting γTuRC recruitment and microtubule nucleation at MTOCs
Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting the formation of ...
Bilingual insights into the initial lexicon: the role of cognates in word acquisition
Bilingual infants acquire words at a similar rate as monolingual ones, despite navigating a more intricate linguistic environment. The mechanisms behind this phenomenon remain elusive. Our project addressed the potential ...
