Now showing items 1624-1643 of 3292
Nadimpalli, Hima Priyanka (Date of defense: 2017-12-11)
Cytoplasmic polyadenylation is a widespread mechanism to control mRNA translation. In vertebrates, this mechanism requires two sequence elements in the 3’ UTR of substrate mRNAs, the U-rich Cytoplasmic Polyadenylation ...
Villanueva Cañas, José Luis (Date of defense: 2015-11-20)
Although the genome sequencing revolution is still in its infancy, we must acknowledge it as the major driver of biology since the beginning of the 21st century. The availability of a large collection of complete mammalian ...
Walsh Capdevila, Sandra (Date of defense: 2019-12-18)
Africa is the origin source of modern humans. Despite that African populations harbor the highest levels of genetic diversity worldwide, they remain underrepresented in genetic studies. Therefore, in order to fully understand ...
Serra Vidal, Gerard (Date of defense: 2018-12-05)
Àfrica és l'origen de totes les poblacions humanes actuals, i malgrat contenir els nivells més elevats de diversitat genètica, la seva història demogràfica ha estat relativament poc estudiada, amb moltes preguntes rellevants ...
Salvador Serna, Miquel (Date of defense: 2003-12-18)
La tesis toma como objeto de estudio los procesos de surgimiento, configuración y desarrollo de los sistemas autonómicos de función pública, a partir de la aparente paradoja sobre su tendencia a converger más allá de las ...
Ginés i Fabrellas, Anna (Date of defense: 2011-11-17)
L’objecte de la tesis és analitzar, des d’una perspectiva interdisciplinar i transversal, els instruments de compensació del dany derivat d’accident de treball o malaltia professional: prestacions de la Seguretat Social, ...
Ribeiro, Rita (Date of defense: 2004-03-29)
Esta tesis explora el problema de la integración de procesos, dentro de la logística y también con otras áreas de la empresa, desde el punto de vista de la planificación estratégica.<br/>El primer estudio, explora tres ...
Bota, Patricia Mirela (Date of defense: 2024-05-21)
Protein-protein interactions (PPIs) are fundamental in driving biological processes and maintaining life’s diverse functions. They play a key role in cellular regulation, facilitating our understanding of both basic ...
Wang, Yang (Date of defense: 2021-06-03)
This thesis uses quantitative and qualitative analyses to explore the integration of Chinese minorities living in Spain – especially, of the second generation born or educated in the country – and the problems of discrimination. ...
Cuenca-Ardura, Mirabai (Date of defense: 2024-01-19)
HNF1A encodes a key transcription factor in insulin-secreting beta cells from pancreatic islets. Heterozygous mutations in HNF1A cause monogenic diabetes, and hypomorphic variants in HNF1A increase the risk for type 2 ...
Bauer, Moritz (Date of defense: 2020-02-14)
The reactivation of the inactive X chromosome has the potential to provide a unique system to study the developmentally induced formation of euchromatin. However, insights into this process were hampered by the lack of ...
Bauer-Mehren, Anna (Date of defense: 2010-11-08)
Despite some great success, many human diseases cannot be effectively treated, prevented or cured, yet. Moreover, prescribed drugs are often not very efficient and cause undesired side effects. Hence, there is a need to ...
Bradbury Lobato, Melissa (Date of defense: 2020-03-20)
High-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. It is characterised by presenting defects in the homologous recombination repair, most frequently associated to BRCA1 mutations. ...
Toufighi, Kiana (Date of defense: 2014-10-31)
Over the last several decades, the emerging ‘integrated’ view of the cell has triumphed over the ‘one gene/one protein/one function’ paradigm. This is illustrated by the biologically opposite effects of key regulatory ...
Jené i Sanz, Alba (Date of defense: 2013-04-29)
El càncer ha estat tradicionalment considerat una malaltia fonamentalment genètica, però recentment s'està fent palès que la desregulació de mecanismes epigenètics contribueix en gran manera al desenvolupament tumoral. ...
Lloréns Rico, Verónica (Date of defense: 2016-09-15)
One of the major challenges of biology is to understand how entire cells or organisms behave in homeostasis and in response to perturbations. Whole-cell modeling promotes this understanding by integrating different cellular ...
Perez, Marcos Francisco (Date of defense: 2018-01-30)
For unknown reasons, genetically identical animals often differ substantially in their phenotypic traits, even in a controlled environment. Here I investigate the causes of inter-individual physiological variation using a ...
Martin, Olivier M. F. (Date of defense: 2022-04-05)
Gràcies als amplis esforços d'investigació, la nostra comprensió dels mecanismes fisiològics de l'envelliment ha progressat enormement. Recentment, les tecnologies òmiques han permès l'estudi a tot el genoma dels canvis ...
Segura Agulló, Mireia (Date of defense: 2004-07-09)
La 3,4-metilendioximetamfetamina (MDMA, èxtasi) és una droga de síntesi que es consumeix entre els joves de forma recreativa. S'ha postulat que la 3,4-dihidroximetamfetamina (HHMA), metabòlit que es forma a partir de ...
Colás Álvarez, Joaquim (Date of defense: 2017-09-20)
Storytelling is one of the oldest models of cultural expression in human history. Thanks to the evolution of information technologies, the Web 2.0 paradigm has impacted in this field: some modern audiences actively participate ...