Universitat Pompeu Fabra
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Models computacionals basats en xarxes a gran escala d'inspiració neurobiològica permeten descriure els correlats neurals de la decisió observats en certes àrees corticals com una transició entre atractors de la xarxa ...
Disruption of communication in brain circuits involving the prefrontal cortex (PFC) and the hippocampus (HPC) has been suggested to be a hallmark characteristic of schizophrenia. Therefore, a better understanding of the ...
Myotonic dystrophy type 1 (DM1) is a rare disease characterized by muscular defects, as well as, cognitive and mood alterations. Although these neurophysiological disturbances are very debilitating, there is lack of data ...
Early life experiences play a key role in brain function and behaviour. Maternal separation produced negative early life experiences that induce emotional alterations. Contrary, the communal nest has been proposed as a ...
Chronic pain is currently a major clinical issue that represents huge economic and social burdens. Chronic pain treatment currently available presents limited efficacy and significant side effects. One of the reasons for ...
(+) 3,4-metilendioximetanfetamina (MDMA), popularmente conocida como "éxtasis", es una droga susceptible de producir adicción en algunos individuos. Actualmente es consumida principalmente por adolescentes y jóvenes. Los ...
Memory is a complex brain function that constitutes a crucial feature of individuals. Understanding the precise neurobiological mechanisms involved is a fundamental challenge in Neuroscience, where multiple brain areas and ...
The easy access to palatable foods is a major contributing factor for compulsive eating and development of food addiction, a disorder closely linked to obesity and binge eating disorder. The concept of food addiction is ...
El cànnabis i l’èxtasi són dues drogues d’ús recreatiu, les quals usualment es solen consumir de forma conjunta. Degut al seu ús combinat, resulta difícil esclarir les conseqüències que té cada droga a nivell neurobiològic. ...
El aprendizaje visuomotor condicional es un paradigma en el que las asociaciones estímulo-respuesta se aprenden a través de una recompensa. Un experimento típico se desarrolla de la siguiente forma: cuando se presenta un ...
Decision confidence offers a window on introspection and onto the evaluation mechanisms associated with decision-making. Nonetheless we do not have yet a thorough understanding of its neurophysiological and computational ...
The recently discovered decapeptide kisspeptin and its G-protein coupled receptor form a signaling system expressed ubiquitously and are implicated in a variety of still poorly characterized functions. In the brain, ...
To date, there are scarce data on bowel dysfunction (BD) in patients after brain injury (BI). Until now, only fecal incontinence (FI) has received attention and it has been mainly associated to patients’ age or performance ...
This Thesis aims at addressing the therapeutic potential of a neuroplasticity-targeted treatment for intellectual disability (ID) in Down syndrome (DS). The therapy consisted of the administration of the green tea catechin ...
In this thesis, we have developed a hypoxia-ischemia (HI) model in adult mice to study the neuroprotective mechanisms of CB2 cannabinoid receptors (CB2R), and the potential therapeutic effects of the new PPAR-α agonist, ...
Williams-Beuren syndrome is a neurodevelopmental disorder caused by a heterozygous deletion of 26-28 genes in 7q11.23. Despite the great advances on the knowledge of the clinical phenotype and the molecular causes of the ...
In these days of significant changes and the rapid evolution of technology, the amount of datascience has to deal with the growth incredibly fast, and the size of data could be prohibitive.Multiple Sequence Alignments (MSA) ...
Animal models are crucial to improve the knowledge of the mechanisms underlying the different pathological processes. These models are also excellent tools to facilitate the research of new targets for the treatment of ...
The breakthrough in the technological field has allowed the extraction of large amounts of the so-called omics data. The analysis and Integration of this type of data by means of advanced statistical and bioinformatics ...
The rapid increase of obesity has encouraged the study of the aetiology of eating disorders. Besides genetic, social and metabolic factors, obesity is caused by over-eating and has high rate of relapse to abnormal food-taking ...
