Facultat de Medicina: Recent submissions
Now showing items 1-20 of 459
Integrative Chromatin Profiling in Mature B cell Lymphomas: Biological and Clinical Insights
[spa] La molécula de ADN contiene toda la información necesaria para el desarrollo de los organismos vivos. El ADN se encuentra compactado en el núcleo de las células humanas, envuelto alrededor del nucleosoma, un complejo ...
Regulation of CK2 by phosphoinositides and inositol pyrophosphates: implications in endocytosis
[ENG] CK2 is a constitutively active serine/threonine kinase that consists in a tetramer composed by two catalytic and two regulatory subunits (termed Cka1, Cka2, Ckb1 and Ckb2 in yeast, respectively). Catalytic subunits ...
Epigenomic Dynamics Associated with Myeloid Cell Immune Response Remodeling
[eng] Monocytes are highly plastic cells and possess the ability to differentiate into cell types with very different immunological properties. Depending on the external stimuli and the specific immune context, they can ...
Impacto de la respuesta viral sostenida en la recurrencia de la hepatitis C tras el trasplante hepático
[spa] El desarrollo de los nuevos antivirales de acción directa ha permitido lograr la erradicación viral en un porcentaje muy alto de pacientes con infección por VHC, incluso en estadios de fibrosis hepática avanzada y ...
Estudio de las alteraciones genéticas para validar y refinar su impacto pronóstico en leucemia mieloide aguda
[spa] La leucemia mieloide aguda (LMA) es la leucemia más frecuente, siendo una neoplasia agresiva con una supervivencia limitada. La LMA presenta mutaciones recurrentes de manera frecuente, y se sabe que estas pueden tener ...
Características clínicas e indicadores pronósticos de reingreso y mortalidad de una cohorte de pacientes que ingresan por primera vez por insuficiencia cardíaca en un hospital universitario de tercer nivel: un estudio observacional de 5 años
[spa] La Insuficiencia cardiaca es una condición de elevada prevalencia cuya frecuencia aumenta con la edad y tiene un impacto notable en el gasto sanitario. Los primeros meses tras el alta de la primera hospitalización ...
Estudio de la integridad de sustancia blanca mediante tractografía por tensor de difusión: Simulación, Diagnóstico y Pronóstico
[spa] En la presente Tesis hemos establecido tres hipótesis de trabajo que comprenden todo el arco argumental subyacente a las aplicaciones clínicas que el DTI puede ofrecer en la práctica clínica neuroquirúrgica. I. Las ...
Hipertensión portal: Avances en su diagnóstico e impacto en el riesgo quirúrgico
[spa] La hipertensión portal es un síndrome clínico que consiste en el aumento patológico y sostenido de la presión en el territorio venoso portal. Su relevancia se ve determinada por las graves complicaciones que produce, ...
Asthma and obesity. Glucocorticoid sensitivity before and after bariatric surgery. Effect of vitamin D
[eng] This thesis has been designed to characterize the low-grade chronic inflammation present in obesity in patients suffering from asthma, and to describe some of the mechanisms involved in the glucocorticoid hyporesponsiveness ...
Pre-clinical development of chimeric virus-like particles based HPV: HIV vaccines by using mammalian cell expression system: limitations and challenges
[eng] HPV and HIV-1 are important public health issues in some developing and industrialized countries, but an effective chimeric HPV:HIV preventive vaccine is still unachievable. We aimed to establish an alternative ...
ldentification of pTINCR: a new ubiquitin-like protein that promotes epithelial differentiation and suppresses tumor growth
[eng] Recent advances in computational analyses, peptidomics and ribosome profiling have revealed that many regions previously annotated as non-coding are in fact translated into a myriad of bioactive proteins, largely ...
Production, purification and characterization of virus-like particles from chimeric HPV-HIV L1P18 protein expressed in Pichia pastoris: Lessons learned
[eng] In this thesis, two recombinant Pichia pastoris strains producing chimeric HPV-HIV L1P18 protein were constructed. One intracellularly produces the chimeric protein while the other secrets it. For the former, ...
The role of RANK pathway in the intestinal epithelium, breast cancer and tumor immune modulation
[spa] La vía de RANK juega un papel crucial en remodelación ósea, con un anticuerpo monoclonal (denosumab) contra el ligando de la vía de señalización (RANKL), actualmente usado en clínica contra la osteoporosis y efectos ...
The role of cyclin-dependent kinase 5 (Cdk5) in colorectal cancer
[cat] El càncer colorectal (CCR) és el tercer càncer més freqüent en homes i el segon en dones a nivell mundial. Tot i que les taxes de supervivència a 5 anys en els primers estadis superen el 90%, la situació canvia ...
Ancestral roles of IĸB proteins in Caenorhabditis elegans
[eng] Mammalian Inhibitor-of-kappa-B (IκBs) proteins exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has ...
Dissecting genetic regulatory mechanisms in human pancreatic islets to gain insights into type 2 diabetes pathophysiology
[eng] Diabetes mellitus is a heterogeneous group of metabolic diseases characterized by impaired blood glucose homeostasis that affects more than 415 million people worldwide and is a leading cause of mortality. The most ...
Identity and functions of dendritic cell subsets in ischaemia-induced neuroinflammation
[eng] Cerebral ischaemia induces several inflammatory processes in the brain. Among them, the infiltration of immune cells is a hallmark of the pathology. Dendritic cells (DCs) are usually present in low numbers in the ...
Combined Therapies for Neuroblastoma Based on the Activation of the Calcium- Sensing Receptor
[eng] Neuroblastoma (NB) is the most common extracranial solid childhood tumour. Its clinical and histological manifestations range from benign tumours that spontaneously regress to highly aggressive metastatic tumours ...
Role of CD44 in clear cell renal cell carcinoma invasiveness after antiangiogenic treatment
[eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to develop different ...
Molecular mechanisms of resistance to therapy in glioblastoma
[cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...
