Programa de Doctorat en Ciències: Recent submissions
Now showing items 1-20 of 289
Fístulas arteriovenosas endovasculares. Una nueva opción para los pacientes en hemodiálisis.
La tesis doctoral gira en torno a los resultados obtenido con la utilización de un nuevo sistema endovascular para la realización de fístulas arteriovenosas en los pacientes en hemodiálisis. Se trata de una tesis por ...
Development of Thin Film Layers for Solar Cells through Advanced Deposition Methods
This doctoral thesis explores the development of thin-film layers for photovoltaic devices using advanced deposition techniques. It encompasses three different chapters. The first work advanced NiOx thin-film development ...
Chemical tools targeting proteases: design, synthesis, and biological evaluation for therapeutic use
This PhD thesis focuses on the design, synthesis, and evaluation of chemical compounds that inhibit proteases and degrade proteins essential for cellular recycling. It is divided into two parts: the first explores protein ...
Transporte y liberación de moléculas bioactivas en cultivos de células cancerígenas humanas utilizando nanotransportadores moleculares
La prevalencia del cáncer sigue en aumento y afecta a personas cada vez más jóvenes. Muchos fármacos anticancerígenos presentan problemas de solubilidad y efectos secundarios, lo que destaca la necesidad de mejorar su ...
Taking advantage of zoophytophagous-induced plant defenses to improve pest management in horticultural crops
The growing global demand for food and the increasing challenges posed by climate change call for the development of innovative and sustainable strategies to enhance crop resilience against biotic and abiotic stressors. ...
Bioactive molecules against proteasome and cysteine proteases. Synthetic approach to vicinal diamines
This PhD thesis presents research advancements in the fields of organic synthesis and medicinal chemistry. The work is structured into three chapters, each focusing on distinct topics. The first chapter explores the synthesis ...
Electrocatalytic systems for the synthesis of value-added products
To address the challenges posed by climate change and global warming, there is a pressing need to utilise renewable materials that can be obtained in a safe and environmentally friendly manner. The utilisation of biomass ...
Homogenous catalysis by molybdenum sulfide clusters and the study of their sulfur-centered mechanisms
The present doctoral thesis is included within the homogenous catalysis field. A comprehensive study has been conducted on the catalytic activity of molybdenum sulfide cluster compounds coordinated with nitrogen-donor ...
Metal complexes with naphthalene-diimide and perylene-diimide-based ligands: supramolecular interactions and catalytic implications
This doctoral thesis delves into the design and development of new ligand precursors and organometallic complexes through the combination of two different types of rylene-diimides (RDIs), with N-heterocyclic carbene ...
Unraveling the mechanism of CH3CH2OH dehydrogenation on m-ZrO2(111) surface, Au13 cluster, and Au13 cluster/m-ZrO2(111) surface: a DFT and microkinetic modeling study
In this study, we investigate the dehydrogenation of ethanol and the production of CH3CHO and H2 on the m-ZrO2(111) surface, an Au13 cluster, and Au13/m-ZrO2(111) surface, using density functional theory simulations. Our ...
Biomaterials based on LMWG-polymer multicomponent supramolecular hydrogels
Supramolecular hydrogels are formed through the self-assembly of low-molecular-weight gelators (LMWGs) in water, creating three-dimensional fiber networks via non-covalent interactions. The primary drawback of supramolecular ...
Impacto del ejercicio de Ultra Trail sobre el estado oxidativo del plasma y su relación con el daño muscular y la aparición de fatiga en una muestra de corredores amateurs
El estrés oxidativo se ha estudiado ampliamente en asociación con los deportes de ultrarresistencia sin que haya un consenso sobre las repercusiones del mismo. El objetivo de este estudio fue dilucidar el impacto de una ...
Developing mitigation strategies to alleviate abiotic stress conditions in citrus plants
The climate change situation has worsened in recent decades, and this has negatively affected certain economic activities, particularly agriculture. Crops have been impacted by heatwaves, exposure to high light intensity, ...
Supramolecular materials based on short peptides: design, synthesis and applications
In this study, we planned to obtain supramolecular materials based on short peptides with a low-cost and high-efficiency synthesis procedure, which have an acceptable toxicity rate and can be applied in biological systems ...
Síndrome metabólico y abuso de alcohol: efectos de la acción combinada de ambas patologías en el balance oxidativo del sistema nervioso central
El síndrome metabólico es un clúster de anormalidades fisiológicas y bioquímicas entre las que se incluyen la resistencia a la insulina, obesidad central, dislipidemia, hipertensión e intolerancia a la glucosa. El consumo ...
(E)-Styryl derivatives for the discovery of anticancer and antiviral agents
The present doctoral thesis is situated within the field of medicinal chemistry and the main objective is to design and evaluate organic small molecules with potential anticancer activity and to assess their potential as ...
Geometric Numerical Integration for Hamiltonian Monte Carlo and Extrapolation
Hamiltonian ordinary differential equations (ODEs) occur in many applications (celestial mechanics, molecular dynamics, sampling) and their efficient numerical integration is thus of great interest. This thesis reviews the ...
Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
This thesis explores peptide-based nanocarriers, specifically cationic vesicles and nanogels formed from bolaamphiphilic molecules with a cystamine core and dipeptide groups. The first chapter discusses how these molecules ...
Redox-switchable and metallaphotoredox catalysts based on NDI/PDI-NHC complexes
The research presented in this doctoral thesis focuses on the preparation of novel metal complexes bearing a naphthalene-diimide (NDI) or perylene-diimide (PDI) fragment connected to an N-heterocyclic carbene (NHC) ligand. ...
Formulation of nanoparticles with application in agriculture
Plants face extreme climatic conditions that threaten their survival and productivity. To address this issue, salicylic acid (SA) encapsulates have been developed as a palliative treatment against various abiotic stresses. ...
