Programa de Doctorat en Ciències: Recent submissions
Now showing items 1-20 of 276
Supramolecular materials based on short peptides: design, synthesis and applications
In this study, we planned to obtain supramolecular materials based on short peptides with a low-cost and high-efficiency synthesis procedure, which have an acceptable toxicity rate and can be applied in biological systems ...
Síndrome metabólico y abuso de alcohol: efectos de la acción combinada de ambas patologías en el balance oxidativo del sistema nervioso central
El síndrome metabólico es un clúster de anormalidades fisiológicas y bioquímicas entre las que se incluyen la resistencia a la insulina, obesidad central, dislipidemia, hipertensión e intolerancia a la glucosa. El consumo ...
(E)-Styryl derivatives for the discovery of anticancer and antiviral agents
The present doctoral thesis is situated within the field of medicinal chemistry and the main objective is to design and evaluate organic small molecules with potential anticancer activity and to assess their potential as ...
Geometric Numerical Integration for Hamiltonian Monte Carlo and Extrapolation
Hamiltonian ordinary differential equations (ODEs) occur in many applications (celestial mechanics, molecular dynamics, sampling) and their efficient numerical integration is thus of great interest. This thesis reviews the ...
Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
This thesis explores peptide-based nanocarriers, specifically cationic vesicles and nanogels formed from bolaamphiphilic molecules with a cystamine core and dipeptide groups. The first chapter discusses how these molecules ...
Redox-switchable and metallaphotoredox catalysts based on NDI/PDI-NHC complexes
The research presented in this doctoral thesis focuses on the preparation of novel metal complexes bearing a naphthalene-diimide (NDI) or perylene-diimide (PDI) fragment connected to an N-heterocyclic carbene (NHC) ligand. ...
Formulation of nanoparticles with application in agriculture
Plants face extreme climatic conditions that threaten their survival and productivity. To address this issue, salicylic acid (SA) encapsulates have been developed as a palliative treatment against various abiotic stresses. ...
Metabolic adaptations in plants under the combination of salinity and high irradiance
Climate change is shown as a combination of atmospheric phenomena and human-made pollution that have been aggravated over the last years. Among the different climate changeassociated environmental conditions, increased ...
New developments and applications of Archetypal Analysis
This thesis advances data analysis through innovative methodologies centered on archetypal analysis (AA) and its extensions. It introduces archetypoid analysis for classifying foot shapes, improving footwear design by ...
Quantum codes and locally recoverable codes from evaluation codes
This PhD thesis addresses two current problems belonging to the fields of classical and quantum information theory. The first is the repair problem in distributed and cloud storage systems in the setting where multiple ...
Extracellular DNA-Induced Resistance as a Damage Associated Molecular Pattern (DAMP) in plants
Recent studies have underscored the significance of extracellular DNA (eDNA) as a trigger for defense responses in plants. Our results demonstrated that Arabidopsis thaliana responds to the application of eDNA in a ...
Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogs
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has increased the development of new antiviral drugs to stop its spread. This work focused on synthesizing specific inhibitors of the Mpro protease, crucial for the ...
Exploring the Multifaceted Powers of Solanum lycopersicum Heme-Binding Protein 2 (SlHBP2): A Dynamic Investigation into Antimicrobial, plant Immune-Boosting, and Anticancer Potential
This research investigated the mechanisms of action of Solanum lycopersicum heme-binding protein (SlHBP2) against the bacterial pathogen Pseudomonas syringae pv. tomato DC3000 (Pst) and SlHBP2 potential for boosting plant ...
Polipropileno modificado con semiconductores de plata: composites con alto potencial contra el SARS-CoV-2 y otros patógenos
Como resultado de esta investigación, se propone la fabricación de compuestos poliméricos destinados a crear superficies biocidas seguras, que puedan ser aplicados de manera económica en equipos de protección personal ...
Síntesis de pigmentos cerámicos rojos con composición YAlO3 dopados con cromo
Se han sintetizado pigmentos cerámicos de coloración roja con estructura perovsquita YAlO3 dopados con cromo. Se ha estudiado la vía de síntesis mediante la ruta cerámica tradicional y la vía coprecipitación, mediante el ...
Single-pixel Computational Imaging: Application to Fluorescence and Diffuse Optical Imaging
In this dissertation, we demonstrate the use of single-pixel imaging methods in two important imaging modalities in biomedical applications, time-resolved fluorescence imaging and diffuse optical imaging. In fluorescence ...
(Photo)electrochemical approaches for renewable energy storage into high-added value chemicals
An energy transition toward a clean and sustainable model is crucial to overcome the well-known problems related to traditional coal energy consumption. In this regard, the generation and storage of renewable energies is ...
Mycorrhiza-induced resistance as a hub for plant immunity against pathogens and pests
Plants have developed an immune system that allows them to cope with harmful organisms. This resistance can be stimulated through the use of beneficial organisms such as Arbuscular Mycorrhizal Fungi. Understanding the ...
Synthesis of highly functional polypeptides and polypeptoids via N-carboxyanhydride ring opening polymerization as drug delivery nanosystems
In this work, N-carboxyanydride ring opening polymerization (NCA-ROP) has been widely explored and used as synthetic strategy for the synthesis of polypeptides and polypeptoids affording well-defined polymers with low ...
Molybdenum sulfide cluster catalysts in hydrogenation and dehydrogenation reactions: a combined theoretical and experimental study
This doctoral thesis addresses the synthesis, structural characterization and applications as homogeneous catalysts of molybdenum sulfide clusters decorated with ligands containing amino groups. In particular, hydrogenation ...
