Facultat de Farmàcia i Ciències de l'Alimentació: Enviaments recents
Ara mostrant els elements 141-160 de 331
Design and synthesis of new potentially inhibitors of PCSK9 and KRAS proteins
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major cause of deaths in ...
Biophysical Techniques for the Investigation of Protein-Ligand Complexes
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several stages. In this ...
Application of computational docking to the characterization and modulation of protein-protein interactions of biomedical interest
The study of the 3D structural details of protein interactions is essential to understand biomolecular functions at the molecular level. In this context, the limited availability of experimental structures of protein-protein ...
Development of crystallographic methods for phasing highly modulated macromolecular structures
Pathologies that result in highly modulated intensities in macromolecular crystal structures pose a challenge for structure solution. To address this issue two studies have been performed: a theoretical study of one of ...
Targeting strategies against Plasmodium and practical applications: blocking parasite development with heparin derivatives and identifying new aptamers for diagnosis
La malaria es una enfermedad infecciosa producida por Plasmodium, protozoo transmitido a través de la picadura de mosquitos del género Anopheles. Aunque existen tratamientos y medidas de prevención, en los países tropicales ...
New antimicrobial strategies against bacterial infections
Bacterial infections are a major health concern worldwide due to the mortality and comorbidity associated levels. Besides the development of drug-resistance mechanisms, most recalcitrant infections are caused by bacteria ...
Heterogeneity of carcinoma-associated fibroblasts and REV-ERB-induced phenotype molding in pancreatic ductal adenocarcinoma
Tumor-stroma crosstalk is essential for PDAC formation. Therefore, the stroma, and specifically the carcinoma-associated fibroblasts (CAFs), are the target of therapeutic alternatives to treat highly desmoplastic tumors ...
New insights into RANK signaling pathway in the mammary gland
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive inhibitor that ...
Structural analysis of macromolecular folds and the application to phasing
Determining and understanding protein structure in atomic detail is a fundamental process to the advancement of biotechnology and biomedicine, shedding light the role of macromolecules and their complexes, their biological ...
Human Primary Organoid-Derived Epithelial Monolayers as a Novel Strategy for the Study of Adherent Invasive Escherichia coli pathogenicity and the effects of Postbiotics on Intestinal Epithelial Function
Inflammatory bowel disorders – such as Inflammatory Bowel Disease (IBD) – are rising worldwide. A well-known feature of IBD is dysbiosis of the gut microbiota, characterized by a significant reduction of beneficial strains ...
Novel Quatsome nanovesicles, prepared using CO2, for the development of advanced nanomedicines
Quatsomes are lipid-based nanovesicles developed by Nanomol group, composed of ionic surfactants and sterol derivatives. Regarding their properties, Quatsomes have shown to be highly homogenous and stable for years, important ...
Structural and functional analysis of Zika Virus NS5 protein
Zika virus (ZIKV) belongs to the Flaviviridae family and constitute an important public health concern since ZIKV infection produced devastating effects in new born infants. Flaviviruses present a positive sense single ...
Funció i potencial terapèutic de CPEB4 en l’aparició i progressió de lesions hepàtiques en context d’obesitat
El carcinoma hepatocel·lular (HCC) és la segona causa de mort relacionada amb càncer i té avui en dia opcions terapèutiques molt limitades. Tot i que el HCC s’acostuma a estudiar en estats de malaltia hepàtica molt avançats, ...
Involvement of Polyamines in PAMP-triggered Immunity and Systemic Acquired Resistance (SAR). Extragenic Suppressors of Immune Hybrid Incompatibility
The main topic of this Thesis is to investigate the contribution of polyamines to defense in Arabidopsis thaliana and the requirement of callose deposition for full expression of effector-triggered immunity in autoimmune ...
Analysis of the in vivo effect of carnitine palmitoyltransferase 1A deletion in AgRP neurons
Food intake and whole-body energy balance are regulated by the brain through a sophisticated neuronal network located mostly in the hypothalamus. In particular, the hypothalamic arcuate nucleus (ARC) is a fundamental sensor ...
Study of the Regulatory Mechanisms of Gene Expression in Venous Thromboembolic Disease: microRNAs
Venous Thrombosis (VT) is a frequent complex disease that involves a disruption of the balance of the hemostatic system. microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Promising findings in ...
Enhanced hyaluronidase and tumor neoepitope expression by oncolytic adenoviruses
The oncolytic viruses (OVs) preferentially infect tumor and selectively replicate in cancer cells without harming normal tissues. OVs have been tested in clinical trials as monotherapy or combined with chemotherapy, ...
Comprehensive high performance thin layer chromatography (HPTLC) fingerprinting in quality control of herbal drugs, preparations and products
Quality control of herbals has its roots in the study of morphoanatomic and organoleptic characters. Nevertheless, in the last century, with the evolution of analytical chemistry, the quality control rapidly evolved from ...
Problemas de adherencia al inicio de tratamientos para la enfermedad cardiovascular y diabetes
INTRODUCCIÓN: La patología cardiovascular es prevalente y causa una elevada mortalidad, discapacidad y carga económica a nivel mundial. La falta de adherencia a los tratamientos para la enfermedad cardiovascular y la ...
Tamaño crítico: efectos e implicaciones en crecimiento y ciclo celular
En Ia levadura de gemación el tamaño celular en START o tamaño crítico está determinado por Ia velocidad de crecimiento en G1. Durante esta fase, Saccharomyces cerevisiae presenta una disminución de Ia relación ...
