Programa de Doctorat en Biomedicina: Recent submissions
Now showing items 121-140 of 1388
Uncertainty analysis of individual predictions and integrated safety assessments in toxicology
The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory decisions regarding chemical safety. The general objective of this thesis is to identify gaps in state-of-the- art ...
Inhaled treatment and patient-reported outcomes in asthma
The general aim of this doctoral thesis was to examine the impact on persons with persistent asthma of inhaled treatment use and sociodemographic factors, in terms of patient-reported outcomes. To achieve this, a new ...
Characterization of synthetic lethality between MYC activation and splicing inhibition in an immortalized cell line : roles of alternative splicing
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...
The Hajar Mountains of Southeastern Arabia: a laboratory to understand how reptile diversity is generated, distributed and maintained in arid environments
This thesis provides new insights into the evolution of biodiversity in arid regions by exploring the patterns and drivers of reptile diversity in the Hajar Mountains of Southeastern Arabia. We first assemble a genomic ...
Exploring the frontiers of synthetic biology: modelling, characterization, and applications of genetics circuits
Engineering biology requires a clear set of rules that ensure design predictability. However, certain biological processes difficult the application of these rules, impairing prediction. In the first section of this PhD ...
The price of deciding: balancing resource constraints for optimisation
Prendre decisions es un repte, i a la par un aspecte inevitable a les nostres vides. D’entre totes les opcions viables, hom ha de sotmetre a escrutini i avaluació les diverses alternatives en tant gestionant la frustració ...
Adaptations in cancer: a molecular and mechanistic rewiring
Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...
Temporal resolution by multiomic approaches of acute myeloid leukemias
Acute myeloid leukemias (AMLs) are a type of cancer where undifferentiated myeloid cells abnormally proliferate. Such phenotype can be caused by the expression of chimeric proteins like PML-RARα and MLL-AF9. Many studies ...
Understanding the molecular basis of neuronal 3'UTR length-dependent mRNA sorting
The local translation of messenger RNAs (mRNAs) within different neuronal compartments is a prerequisite the formation of long-term memories. mRNAs are localized via active transport along microtubules, however, the ...
Integration of genetic and chemical screens to discover targeted therapies for HNF1 A-deficient diabetes
HNF1A encodes a key transcription factor in insulin-secreting beta cells from pancreatic islets. Heterozygous mutations in HNF1A cause monogenic diabetes, and hypomorphic variants in HNF1A increase the risk for type 2 ...
Mitochondria-to-cytosol H2O2 fluxes in redox biology
Los efectos del H2O2 en la fisiología celular, como oxidante y como señalizador es un campo que aún esta en expansión. Para intentar desvelar como ocurren estos fenómenos, hemos utilizado sondas codificadas genéticamente ...
Saludables i equitatives : disseny i avaluació d'intervencions socioeducatives de promoció de les relacions saludables i equitatives en contextos d'educació formal
Les relacions de poder, que són hegemòniques a la nostra societat, causen i perpetuen les iniquitats socials, fent ús de les violències per sostenir les asimetries i afectant negativament a la salut física, mental i social ...
The tumor-supressive role of RNF144B: a p53-activated E3 ligase guarding genomic stability
El conegut supressor tumoral p53 regula un ampli programa transcripcional que protegeix envers el càncer. No obstant, la complexitat d’aquest programa fa difícil determinar el rol de cada gen regulat per p53. Deplecionar ...
Sleep in the preclinical stages of Alzheimer's disease: a multimodal biomarkers approach
This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. ...
Work trajectories after a sickness absence due to cancer in Catalonia (Spain)
The project focuses on cancer and its effects on work trajectories from a life course perspective, both from a qualitative and quantitative approach. Quantitative analyses were based on a retrospective dynamic cohort of ...
NKG2A blockade as a potential strategy to improve NK cell-mediated ADCC in HER2+ breast cancer
Several studies support the contribution of antibody-dependent NK cell cytotoxicity (ADCC) to the clinical efficacy of anti-HER2 therapeutic antibodies in HER2-positive breast cancer. Novel anti-HER2 antibody drug conjugates ...
De novo genome assemblies of endagered species and challenging chromosomes
Modern biology relies on genomic references to perform analyses in most studies. High-quality de novo genome assemblies are key to having references containing all the genomic content of a species. Here I use avant-garde ...
Detection of selection signals on regulatory units across human cancers
Tumor progression is dominated by two evolutionary forces: first mutagenesis, which provides the heritable variability where, secondly, natural selection acts. The main challenge of cancer genomics is to identify the somatic ...
Computational studies of DNA damage and repair of alkylating agents and UV light
Living cells are exposed to naturally occurring DNA-damaging agents that promote the loss of genome integrity, threatening the proper functioning of the cell. To counteract the toxic accumulation of DNA damage, organisms ...
Predicting effects of stroke lesions and recovery through whole-brain modeling and brain dynamics
Stroke is the second leading cause of death worldwide and a major contributor to disability. However, our understanding of the consequences of stroke lesions remains limited, relying mainly on behavioral reports and ...
