Programa de Doctorat en Biomedicina: Envíos recientes
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Equivariant graph neural networks in drug discover: from property prediction to molecule generation
Advancements in machine learning have revolutionized various aspects of drug discovery, from molecular property prediction to de novo design. This thesis presents a comprehensive exploration of equivariant graph neural ...
When P. falciparum meets the brain microvasculature: a 3D blood-brain barrier model to study cerebral malaria
La alteración de la barrera hematoencefálica está relacionada con la malaria cerebral, una complicación de la infección por Plasmodium falciparum asociada con la acumulación del parásito en los vasos sanguíneos cerebrales. ...
Machine learning methods of property prediction in drug discovery
Molecular properties are highly important in drug discovery with binding affinity being crucial for selecting hit and lead candidates. Existing machine learning models often lack speed for large-scale screening or lack ...
CEBPa is an orchestrator of trophectoderm specification
La bifurcación entre trofoectodermo y la masa celular interna es la decisión de desarrollo más temprana, pero cómo se inicia y en qué etapa embrionaria ocurre no se entiende completamente. Aquí describimos que el factor ...
Synaptic transcriptomic changes sensitive to pharmacological approaches in fragile X syndrome: from mouse to human
Fragile X syndrome (FXS), the most common monogenic cause of intellectual disability and autism, is characterized by impairment in cognitive function and synaptic plasticity. Several preclinical studies in animal models ...
Evaluation of tumor mutational burden in follicular lymphoma
El linfoma folicular (LF) es el subtipo más frecuente de linfoma no-Hodgkin indolente, caracterizado por un buen pronóstico a pesar de considerarse incurable. Sin embargo, algunos pacientes presentan un curso clínico más ...
Fixing a broken heart: Zebrafish as a model for heart regeneration drug discovery
Myocardial infarction (MI) remains a leading cause of mortality, with currently available treatments addressing symptoms rather than promoting heart muscle regeneration. Cardiac regeneration strategies, inspired by ...
Genomic analysis of demographic changes in Southern Europe during Roman colonization and Late Antiquity
The expansion of the Roman Empire throughout the Mediterranean region and West Eurasia severely shaped the world culturally and politically. This period has been traditionally studied and researched by historians and ...
Temperature impacts on mortality at different spatial and temporal scales
This PhD thesis investigates the relationship between temperature and mortality at different spatial and temporal scales, addressing a crucial issue in the context of rising temperatures due to anthropogenic climate change. ...
Phylogenetic applications of ancient protein sequences
The resilience of proteins against degradation makes them the longest surviving resource for genomic information. Knowing how much information we can obtain from an ancient sample is crucial because most sampling strategies ...
Analyzing the role of cancer-associated adipocytes in brest tumor metastasis
In breast cancer, the tumor microenvironment includes adipocytes and fibroblasts. When in contact with breast tumor cells, adipocytes undergo lipolysis and dedifferentiation. This thesis demonstrates that cancer-associated ...
Al modelling of real-world patients: applications in prostate cancer
This thesis investigates the integration and analysis of OMICs data to enhance in silico modelling of real-world patients, with a special focus on prostate cancer. By leveraging publicly available transcriptomics data, ...
Urban heat islands and nature-based solutions: insights into health impacts and urban planning determinants
The current and projected rapid urbanization rates underscore the critical role of cities and the urgent need to prioritize the development of healthy and sustainable urban environments. Rising temperatures, intensified ...
A multiscale spatiotemporal map of protein-RNA assemblies in human cells
RNA metabolism is dynamically orchestrated by RNA-binding proteins (RBPs) in different subcellular spaces. Aberrant regulation of the subcellular RNA-protein interactions leads to severe diseases, such as neural degenerations ...
Somatic and germline mutational processes and the evolution of cancer drives genes
Cancer develops from healthy cells due to mutations in around 600 cancer driver genes. These mutations, along with neutral ones, are generated from DNA mutational processes, creating distinct patterns known as mutational ...
Synthetic biology for microbiome-based genetic domestication of the skin and the sea
Microorganisms exhibit remarkable adaptability and represent a vast genetic resource. Synthetic biology aims to leverage this diversity for sustainability and medicine. However, many microbes remain unexplored due to limited ...
Enhancing environmental risk scores with informed machine learning and explainable AI
This thesis explores the development of Environmental Risk Scores (ERSs) that go beyond traditional linear models to capture nonlinear relationships and interactions among a wide range of environmental exposures. Utilizing ...
Investigating cellular hierarchies in acute myeloid leukemia using single-cell genomics
Acute myeloid leukemia is an aggressive type of blood cancer with a poor survival rate. Leukemic stem cells (LSCs) govern the disease by producing rapidly dividing progenitor cells and driving relapse. Molecular characterization ...
Exposure to disinfection by-products and per- and polyfluoroalkyl substances in Barcelona's drinking water and associations with early life outcomes
Los productos químicos como los subproductos de desinfección (DBP) y las sustancias per- y polifluoroalquiladas (PFAS) se encuentran en el agua potable debido a su formación en los sistemas de distribución o su eliminación ...
Multi-omics characterization of histone H1 variants genomic distribution and their contribution to chromatin compartmentalization and transposable elements regulation
The human histone H1 family comprises up to seven somatic subtypes. Using an integrative multi-omics approach that incorporates ChIP-Seq, Hi-C, RNA-Seq, and ATAC-Seq data, this thesis explores the genome-wide distribution ...
