Programa de Doctorat en Biomedicina: Envíos recientes
Mostrando ítems 81-100 de 1388
The gastrulating zebrafish under heat waves and cold spells: developmental robustness and vulnerabilities under changing temperatures
Temperature affects all processes, including development, and yet, it remains unknown how and/or if underlying mechanical and biochemical events are coordinated to slow down development robustly at lower temperatures. Here, ...
Electrical conductivity of hepatic tissue and its manipulation by intraarterial infusion of glucose: preliminary in vivo experiences in rats and patients
This study explores the potential of irreversible electroporation (IRE) in the treatment of scattered liver tumors, focusing on the electrical properties of the tissue. The administration of a 5% glucose solution (GS5%) ...
Mapping protein-coding genomes to phenomes: a phylogenetic perspective
In the current genomics era, it is essential to understand how the existing genomics diversity across evolution is linked to the enormous diversity we observe at the phenotypic level. Until now, Genome-wide association ...
Characterisation of walking in older adults: chronic obstructive pulmonary disease (COPD) as a case study
Background: Walking is crucial for an active and healthy ageing. Aim: To understand walking in ageing populations, and, as a case study, in chronic obstructive pulmonary disease (COPD). Methods: This thesis (in seven ...
"Somitogenesis unbound": dissecting the spatiotemporal control of mammalian embryo segmentation through in vitro models of development
Stem cell-based in vitro systems have recently been used to complement the study of developmental processes in the embryo. Somitogenesis, which segments a vertebrate body axis to establish its characteristic body plan, ...
Exploring the pathogenesis of rare disorders: novel approaches from genomics to transcriptomics
Rare disorders have been presumed to be caused by monogenic variation for decades, hindering the diagnosis in some cases. With many rare disease patients still missing a molecular diagnosis after genetic testing, the ...
Systems biology perspectives on cellular senescence and inflammation
This thesis examines inflammation from the perspective of systems biology in two different situations: cellular senescence resulting from unresolved tissue damage and the acute immune response to the invasion of a pathogen, ...
Impacts of early-life vitamin D on child and adolescent health outcomes
Els baixos nivells de vitamina D durant l’embaràs i els primers anys de la vida són freqüents en dones embarassades i en nadons i, a més, poden tenir implicacions per a la salut de l’infant a llarg termini. Malgrat això, ...
Biological brain-age prediction using machine learning on neuroimaging data: links with pathophysiological mechanisms, dementia risk factors and cognitive decline
This thesis explores the links between neuroimaging-derived brain-age, which is computed using machine learning techniques, and different pathophysiological mechanisms, dementia risk factors and cognitive decline in ...
Exploring the genetic diversity of European ants and butterflies
Biodiversity encompasses the great variety of organisms that exist on Earth, as well as their genetic variation and the ecosystems of which they are part. In this thesis, two diverse and ecologically important groups are ...
Towards development of novel circular RNA-based antiviral therapies
Currently, there are no antiviral strategies to rapidly respond to novel emerging viruses or to mosquito borne viruses. On this thesis we have developed an innovative artificial circular RNA (circRNA) antiviral platform ...
Integrating computational techniques for enhanced understanding of protein-protein interactions and the human interactome
Protein-protein interactions (PPIs) are fundamental in driving biological processes and maintaining life’s diverse functions. They play a key role in cellular regulation, facilitating our understanding of both basic ...
OccRF-Health study: occupational exposure of workers to RF-EMF
Radiofrequency electromagnetic fields (RF-EMF) exposure, ubiquitous in our environment due to the rise in mobile phones and wireless technology, has grown significantly in the last 30 years. This exposure is generally ...
Untangling chromatin: investigating the role of transcription, supercoiling and topoisomerases in genome organization
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada en el interior ...
Role of histone modifications in transcription regulation upon environmental stress in eukaryotes
Epigenetic modification serves as a crucial mechanism in regulating gene expression and facilitating cellular adaptation to environmental stress. This study aimed to identify histone residues and their associated ...
Deciphering B lymphocyte dynamics in health and disease through the integrative analysis of multi-modal single-cell data
The intrinsic complexity and dynamic nature of B-lymphocytes make them ideal for in-depth analysis using single-cell technologies. Secondary lymphoid organs (SLOs) are central in B-lymphocyte activation and differentiation, ...
Modeling cell type evolution using single-cell and chromatin profiling approaches
Single-cell genomics methods have revolutionized the study of gene expression and regulation at the cell type level. Generating single-cell atlases for species at key phylogenetic positions of the animal tree of life (e.g.. ...
Health impacts and determinants of environmental exposures related to urban and transport planning practices in European cities
The rapid increase in urbanization underscores the need for healthy urban environments. Presently, European cities experience high levels of air pollution, noise, lack of green spaces, and increased local temperatures, all ...
Exploring the role of climate variability and change in the spillover of zoonotic diseases: towards the development of Early Warning Systems (RWS)
The primary goal of this PhD is to deepen our understanding and improve the modeling capacity of zoonotic spillover, the multilevel process by which pathogens manage to overcome a series of natural barriers and infect other ...
Experience-dependent information processing in biological systems
Organisms need to integrate its previous experience with its current internal state in order to deliver a suitable response to dynamic changes in their environment. This thesis is devoted to analyze, using a mathematical ...
